6-Isopropyl-2,3,4-trimethyl-phenol | 100519-97-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 6-Isopropyl-2,3,4-trimethyl-phenol
• 英文别名: 2,3,4-Trimethyl-6-propan-2-ylphenol；2,3,4-trimethyl-6-propan-2-ylphenol
• CAS: 100519-97-9
• 化学式: C₁₂H₁₈O
• 分子量: 178.274
• InChiKey: SLXXPUGYCPBYOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-hydroxy-3-isopropyl-5,6-dimethyl-benzaldehyde 在 氢氧化钾 、 一水合肼 、 二乙二醇 作用下， 生成 6-Isopropyl-2,3,4-trimethyl-phenol
  参考文献：
  名称：

  Royer et al., Bulletin de la Societe Chimique de France, 1959, p. 304,308

  摘要：

  DOI：

文献信息

• Fluorine-substituted alkyl phenol compounds and their uses
  申请人：——

  公开号：US20030176513A1

  公开（公告）日：2003-09-18

  The present invention relates to the synthesis of fluorinated forms of alkyl phenol compounds and their subsequent use as pharmaceutical agents. More specifically, alkyl phenol compounds are fluorinated to increase compound volatility such that the compound may be administered to a mammal, such as a human being, by inhalation. The invention also provides an inhaler (or vaporizer), that can be used for administration of the volatile derivatives of fluorine-substituted alkyl phenol compound. Further, different derivatives of fluorine-substituted alkyl phenol compound can be also administered by other routes as described in this document.

  本发明涉及合成氟代烷基苯酚化合物的方法，以及它们作为药物的后续应用。更具体地说，氟代烷基苯酚化合物被氟化，以增加化合物的挥发性，从而可以通过吸入的方式给哺乳动物，如人类进行治疗。本发明还提供了一种吸入器（或雾化器），可用于给氟代烷基苯酚化合物的挥发衍生物进行治疗。此外，本文所述的不同氟代烷基苯酚化合物的衍生物也可以通过其他途径进行治疗。
• FLUORINE-SUBSTITUTED ALKYL PHENOL COMPOUNDS AND THEIR USES
  申请人：Baker Max T.

  公开号：US20080312339A1

  公开（公告）日：2008-12-18

  The present invention relates to the synthesis of fluorinated forms of alkyl phenol compounds and their subsequent use as pharmaceutical agents. More specifically, alkyl phenol compounds are fluorinated to increase compound volatility such that the compound may be administered to a mammal, such as a human being, by inhalation. The invention also provides an inhaler (or vaporizer), that can be used for administration of the volatile derivatives of fluorine-substituted alkyl phenol compound. Further, different derivatives of fluorine-substituted alkyl phenol compound can be also administered by other routes as described in this document.

  本发明涉及合成氟代烷基酚化合物及其作为药物的后续使用。更具体地说，氟代烷基酚化合物被氟化以增加化合物的挥发性，使其可以通过吸入的方式被哺乳动物，如人类，给予。本发明还提供了一种吸入器（或蒸发器），可用于给予氟代烷基酚化合物的挥发衍生物。此外，本文所述的不同氟代烷基酚化合物的衍生物也可以通过其他途径给予。
• US7312250B2
  申请人：——

  公开号：US7312250B2

  公开（公告）日：2007-12-25
• [EN] FLUORINE-SUBSTITUTED ALKYL PHENOL COMPOUNDS AND THEIR USES<br/>[FR] COMPOSES D'ALKYL PHENOL A SUBSTITUTION DE FLUOR ET UTILISATIONS ASSOCIEES
  申请人：UNIV IOWA RES FOUND

  公开号：WO2003077894A1

  公开（公告）日：2003-09-25

  The present invention relates to the synthesis of fluorinated forms of alkyl phenol compounds and their subsequent use as pharmaceutical agents. More specifically, alkyl phenol compounds are fluorinated to increase compound volatility such that the compound may be administered to a mammal, such as a human being, by inhalation. The invention also provides an inhaler (or vaporizer), that can be used for administration of the volatile derivatives of fluorine-substitute alkyl phenol compound. Further, different derivatives of fluorine-substituted alkyl phenol compound can be also administered by other routes as described in this document.