1,2,3,4-tetrahydroquinoline-5-carbonitrile | 939758-72-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1,2,3,4-tetrahydroquinoline-5-carbonitrile
• CAS: 939758-72-2
• 化学式: C₁₀H₁₀N₂
• 分子量: 158.203
• InChiKey: ZAEOGUPVWLRFEK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  35.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,2,3,4-tetrahydroquinoline-5-carbonitrile 在 氢气 作用下， 以 四氢呋喃 为溶剂， 以81.9 %的产率得到(1,2,3,4-Tetrahydroquinolin-5-yl)methanamine
  参考文献：
  名称：

  [EN] PROTEIN DEGRADERS AND USES THEREOF
  [FR] AGENTS DE DÉGRADATION DE PROTÉINE ET LEURS UTILISATIONS

  摘要：

  The present invention discloses a protein degrader such as a GSPT1 degrader and use thereof, particularly use in the prevention and/or treatment of diseases.

  公开号：

  WO2023237116A1
• 作为产物：
  描述：

  5-喹啉甲腈 在 2-[7-(2-Diphenylphosphanylethyl)-1,5-diphenyl-1,5,3,7-diazadiphosphocan-3-yl]ethyl-diphenylphosphane 、 potassium tert-butylate 、 氢气 、 cobalt(II) bromide 作用下， 以 异丙醇 为溶剂， 80.0 ℃ 、500.01 kPa 条件下， 以42 %的产率得到5,6,7,8-Tetrahydroquinoline-5-carbonitrile
  参考文献：
  名称：

  Co/P4N2 催化剂的均相脱芳烃加氢：一种亲核方法

  摘要：

  已被证明是强氢化物供体的Co(P 4 N 2 )H 物种可以以亲核方式将氢阴离子传递给电子富集程度较低的芳烃和杂芳烃。氘标记实验支持迈克尔型反应途径。已进行理论分析以研究 CoH 物种的水合性和芳烃的亲电子性。

  DOI：

  10.1002/chem.202203189

文献信息

• 담즙산 수용체의 효능제인 치환된 이중고리 화합물 및 이의 용도
  申请人：ILDONG PHARMACEUTICAL CO., LTD. 일동제약(주)(120160670930) Corp. No ▼ 110111-6139277BRN ▼803-88-00431

  公开号：KR20180115126A

  公开（公告）日：2018-10-22

  본 발명은 치환된 이중고리 화합물, 이를 포함하는 약제학적 조성물 및 상기 치환된 이중고리 화합물의 제조 방법에 관한 것이다. 특히 본 발명은 담즙산 수용체인 파네소이드 x 수용체(fxr, nr1h4)를 활성화하기 위한 치환된 이중고리 화합물의 약제학적 조성물에 관한 것이다.

  本发明涉及替代的双环化合物、包含该化合物的药学组合物以及制备上述替代的双环化合物的方法。具体而言，本发明涉及用于激活胆汁酸受体转录因子x受体(fxr, nr1h4)的替代双环化合物的药学组合物。
• PYRAZOLO[3,4-B]PYRAZINE DERIVATIVES AS SHP2 PHOSPHATASE INHIBITORS
  申请人：Relay Therapeutics, Inc.

  公开号：EP3630770A1

  公开（公告）日：2020-04-08
• [EN] PYRAZOLO[3,4-B]PYRAZINE DERIVATIVES AS SHP2 PHOSPHATASE INHIBITORS<br/>[FR] DÉRIVÉS DE PYRAZOLO[3,4-B]PYRAZINE EN TANT QU'INHIBITEURS DE LA PHOSPHATASE SHP2
  申请人：RELAY THERAPEUTICS INC

  公开号：WO2018218133A1

  公开（公告）日：2018-11-29

  The present disclosure relates to compounds of formula (I) and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds and compositions of the disclosure
• [EN] HETEROCYCLIC DERIVATIVES AS MALT1 INHIBITORS<br/>[FR] DÉRIVÉS HÉTÉROCYCLIQUES EN TANT QU'INHIBITEURS DE MALT1
  申请人：[en]C4X DISCOVERY LIMITED

  公开号：WO2023148501A1

  公开（公告）日：2023-08-10

  The present invention relates to compounds of formula (I) that are MALT1 inhibitors. The compounds have the structural formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with MALT1.
• Homogeneous Dearomative Hydrogenation with a Co/P ₄ N ₂ Catalyst: A Nucleophilic Approach
  作者：Shaoke Zhang、Rong Zhou、Ya‐Nan Duan、Yang Zhou、Xumu Zhang、Jialin Wen

  DOI：10.1002/chem.202203189

  日期：2023.2.10

  be a strong hydride donor could deliver a hydride ion to less electron-rich arenes and heteroarenes in a nucleophilic manner. Deuterium labeling experiments supported a Michael-type reaction pathway. Theoretical analyses have been conducted to investigate the hydricity of the CoH species and the electrophilicity of the arenes.

  已被证明是强氢化物供体的Co(P 4 N 2 )H 物种可以以亲核方式将氢阴离子传递给电子富集程度较低的芳烃和杂芳烃。氘标记实验支持迈克尔型反应途径。已进行理论分析以研究 CoH 物种的水合性和芳烃的亲电子性。