23-O-acetylbayogenin 28-O-α-L-rhamnopyranosyl(1->2)[β-D-galactopyranosyl(1->3)]-6-O-acetyl-β-D-glucopyranoside | 1020560-11-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 23-O-acetylbayogenin 28-O-α-L-rhamnopyranosyl(1->2)[β-D-galactopyranosyl(1->3)]-6-O-acetyl-β-D-glucopyranoside
• 英文别名: perennisoside II；[(2S,3R,4S,5R,6R)-6-(acetyloxymethyl)-5-hydroxy-4-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl] (4aS,6aR,6aS,6bR,8aR,9R,10R,11S,12aR,14bS)-9-(acetyloxymethyl)-10,11-dihydroxy-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate
• CAS: 1020560-11-5
• 化学式: C₅₂H₈₂O₂₁
• 分子量: 1043.21
• InChiKey: IXKGHYXQFAQYES-UAJXJGMFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  73
• 可旋转键数：
  14
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  327
• 氢给体数：
  10
• 氢受体数：
  21

反应信息

• 作为反应物：
  描述：

  23-O-acetylbayogenin 28-O-α-L-rhamnopyranosyl(1->2)[β-D-galactopyranosyl(1->3)]-6-O-acetyl-β-D-glucopyranoside 在 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 3.0h， 以96.4%的产率得到bayogenin 28-O-α-L-rhamnopyranosyl(1->2)[β-D-galactopyranosyl(1->3)]-β-D-glucopyranoside
  参考文献：
  名称：

  Perennisosides I−VII, Acylated Triterpene Saponins with Antihyperlipidemic Activities from the Flowers of Bellis perennis

  摘要：

  The methanolic extract and its saponin fraction (methanol-eluted fraction) of the flowers of Bellis perennis were found to suppress serum triglyceride elevation in olive oil-treated mice. From the saponin fraction, seven new triterpene saponins, perennisosides I (1), II (2), III (3), IV (4), V (5), VI (6), and VII (7), were isolated together with four known saponins, bellidioside A (8), asterbatanoside D (9), bernardioside B-2 (10), and bellissaponin BS6 (11). The stereostructures of 1-7 were elucidated on the basis of chemical and spectroscopic evidence. Among these saponins, perennisosides I (1) and II (2) showed inhibitory effects on serum triglyceride elevation at doses of 25-50 mg/kg, po.

  DOI：

  10.1021/np8000333