erythrolide E | 132750-50-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: erythrolide E
• 英文别名: [(2R,5R,6S,9R,10S,11S,15S,16S,17R)-15-acetyloxy-6-chloro-9-hydroxy-2,11,15-trimethyl-7-methylidene-3,14-dioxo-4,18-dioxatetracyclo[8.7.1.01,5.011,16]octadec-12-en-17-yl] acetate
• CAS: 132750-50-6
• 化学式: C₂₄H₂₉ClO₉
• 分子量: 496.942
• InChiKey: YDMCLOFPGGUTNM-WDWNJHHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  34
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  125
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 erythrolide E 在 吡啶 作用下， 反应 24.0h， 以100%的产率得到erythrolide E-3-acetate
  参考文献：
  名称：

  New briarein diterpenes from the Caribbean gorgonians Erythropodium caribaeorum and Briareum sp

  摘要：

  Seven new erythrolides (3-9) and the known briarein diterpenes erythrolide A (1) and erythrolide B (2) have been isolated from the gorgonian Erythropodium caribaeorum collected in the U.S. Virgin Islands and Jamaica. A Briareum sp. of gorgonian yielded nine new briarein diterpenes (10-18), which have been named briareolides. The structures of these compounds were determined by spectroscopic methods, especially one- and two-dimensional NMR. The structure and absolute stereochemistry of briareolide B (11) was determined by X-ray crystallographic analysis. Some of the briareolides have displayed antiinflammatory activity.

  DOI：

  10.1021/jo00007a020