Methyl 4-[(4-fluorophenyl)carbamoyl]-5-(4-methoxyphenyl)-5-oxopentanoate | 1227676-14-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Methyl 4-[(4-fluorophenyl)carbamoyl]-5-(4-methoxyphenyl)-5-oxopentanoate
• CAS: 1227676-14-3
• 化学式: C₂₀H₂₀FNO₅
• 分子量: 373.381
• InChiKey: YHGBBGRXDMILJA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  27
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  81.7
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Methyl 4-[(4-fluorophenyl)carbamoyl]-5-(4-methoxyphenyl)-5-oxopentanoate 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 8.0h， 以92%的产率得到Methyl 4-[(4-fluorophenyl)carbamoyl]-5-hydroxy-5-(4-methoxyphenyl)pentanoate
  参考文献：
  名称：

  A convenient synthesis of ezetimibe analogs as cholesterol absorption inhibitors

  摘要：

  A convenient method for the synthesis of ezetimibe analogs as cholesterol absorption inhibitors was described. The key step in the synthesis was the intramolecular ring formation through Mitsunobu reaction. Furthermore, a new series of analogs was designed and synthesized. (C) 2009 Wen Long Huang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2009.08.009
• 作为产物：
  描述：

  N-(4-fluorophenyl)-3-(4-methoxyphenyl)-3-oxopropanamide 、 丙烯酸甲酯（MA） 在 sodium ethanolate 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以96%的产率得到Methyl 4-[(4-fluorophenyl)carbamoyl]-5-(4-methoxyphenyl)-5-oxopentanoate
  参考文献：
  名称：

  A convenient synthesis of ezetimibe analogs as cholesterol absorption inhibitors

  摘要：

  A convenient method for the synthesis of ezetimibe analogs as cholesterol absorption inhibitors was described. The key step in the synthesis was the intramolecular ring formation through Mitsunobu reaction. Furthermore, a new series of analogs was designed and synthesized. (C) 2009 Wen Long Huang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2009.08.009

文献信息

• A convenient synthesis of ezetimibe analogs as cholesterol absorption inhibitors
  作者：Jian Feng Ji、Hui Bin Zhang、Wen Long Huang、Hai Qian、Jin Pei Zhou

  DOI：10.1016/j.cclet.2009.08.009

  日期：2010.1

  A convenient method for the synthesis of ezetimibe analogs as cholesterol absorption inhibitors was described. The key step in the synthesis was the intramolecular ring formation through Mitsunobu reaction. Furthermore, a new series of analogs was designed and synthesized. (C) 2009 Wen Long Huang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.