2,3-二甲氧基-6-(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)吡啶 | 1131335-62-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2,3-二甲氧基-6-(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)吡啶
• 中文别名: 2,3-二甲氧基-6-(4,4,5,5-四甲基-1,3,2-二噁硼戊环-2-基)吡啶
• 英文名称: 2,3-dimethoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
• CAS: 1131335-62-0
• 化学式: C₁₃H₂₀BNO₄
• 分子量: 265.117
• InChiKey: KNGSFEZPJJQMAZ-UHFFFAOYSA-N

物化性质

• 沸点：
  353.2±42.0 °C(Predicted)
• 密度：
  1.09±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  49.8
• 氢给体数：
  0
• 氢受体数：
  5

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2934999090

反应信息

• 作为反应物：
  描述：

  2,3-二甲氧基-6-(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)吡啶 、 (R)-4-((R)-1-(5-bromo-1,2-dimethyl-1H-benzo[d]imidazol-7-yloxy)ethyl)pyrrolidin-2-one 在 [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropiridyl)palladium(II) dichloride 、 caesium carbonate 作用下， 以 乙二醇二甲醚 、 水 为溶剂， 反应 1.0h， 生成 (R)-4-((R)-1-(5-(5,6-dimethoxypyridin-2-yl)-1,2-dimethyl-1H-benzo[d]imidazol-7-yloxy)ethyl)pyrrolidin-2-one
  参考文献：
  名称：

  Syk 억제제

  摘要：

  This text appears to be a scientific or technical document discussing the therapeutic uses of a compound called Syk inhibitor in the treatment of various conditions including cancer and inflammatory diseases. It also mentions the chemical structure of the compound given by the chemical formula I. In the formula, X, X, X, R, R, R, R, and Y are as described in the specification. The document further provides methods for using these compounds and compositions containing compounds or salts thereof of the chemical formula I to treat conditions mediated by Syk.

  公开号：

  KR20160037198A
• 作为产物：
  描述：

  2-溴-6-碘-3-甲氧基吡啶 在 1,1'-双(二苯膦基)二茂铁二氯化钯(II)二氯甲烷复合物 、 potassium acetate 作用下， 以 1,4-二氧六环 、 甲醇 为溶剂， 反应 18.0h， 生成 2,3-二甲氧基-6-(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)吡啶
  参考文献：
  名称：

  [EN] PYRIMIDINES AND METHODS OF THEIR USE
  [FR] PYRIMIDINES ET LEURS PROCÉDÉS D'UTILISATION

  摘要：

  Disclosed are compounds comprising pyrimidinyl core and pharmaceutical compositions useful in the treatment of neurological disorders. The compounds described herein, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological diseases, including FTLD-TDP, chronic traumatic encephalopathy, ALS, Alzheimer's disease, LATE, or frontotemporal lobar degeneration.

  公开号：

  WO2023107603A1

文献信息

• Syk 억제제
  申请人：GILEAD SCIENCES, INC. 길리애드 사이언시즈, 인코포레이티드(519990290219)

  公开号：KR20160037198A

  公开（公告）日：2016-04-05

  본 개시내용은 Syk 억제제인 화합물, 및 암 및 염증성 상태를 비롯한 다양한 질환 상태의 치료에서의 그의 용도에 관한 것이다. 특정한 실시양태에서, 화합물의 구조는 하기 화학식 I로 주어진다. 003c#화학식 I003e# 상기 식에서, X, X, X, R, R, R, R, 및 Y는 본원에 기재된 바와 같다. 본 개시내용은 화학식 I의 화합물 또는 그의 제약상 허용되는 염을 포함하는 제약 조성물, 및 Syk에 의해 매개되는 상태를 치료하기 위해 이들 화합물 및 조성물을 사용하는 방법을 추가로 제공한다.

  This text appears to be a scientific or technical document discussing the therapeutic uses of a compound called Syk inhibitor in the treatment of various conditions including cancer and inflammatory diseases. It also mentions the chemical structure of the compound given by the chemical formula I. In the formula, X, X, X, R, R, R, R, and Y are as described in the specification. The document further provides methods for using these compounds and compositions containing compounds or salts thereof of the chemical formula I to treat conditions mediated by Syk.
• [EN] PYRIMIDINES AND METHODS OF THEIR USE<br/>[FR] PYRIMIDINES ET LEURS PROCÉDÉS D'UTILISATION
  申请人：[en]KINETA, INC.

  公开号：WO2023107603A1

  公开（公告）日：2023-06-15

  Disclosed are compounds comprising pyrimidinyl core and pharmaceutical compositions useful in the treatment of neurological disorders. The compounds described herein, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological diseases, including FTLD-TDP, chronic traumatic encephalopathy, ALS, Alzheimer's disease, LATE, or frontotemporal lobar degeneration.