14-巯基十四酸 | 184639-68-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 14-巯基十四酸
• 英文名称: 14-mercaptomyristic acid
• 英文别名: 14-Mercaptotetradecanoic acid；14-sulfanyltetradecanoic acid
• CAS: 184639-68-7
• 化学式: C₁₄H₂₈O₂S
• 分子量: 260.441
• InChiKey: VPORVJHUQAFEIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  17
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  38.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  14-溴十四烷酸 在 硫脲 、 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 30.0h， 以76%的产率得到14-巯基十四酸
  参考文献：
  名称：

  Development of 11C-Labeled ω-sulfhydryl fatty acid tracer for myocardial imaging with PET

  摘要：

  [C-11]-S-methyl-16-thiopalmitic acid (a) was developed with excellent heart-to-background uptake ratios and higher retention in heart. Myocardial uptake and metabolism of the tracer is markedly higher CPT I dependent. When compared to [C-11]-S-methyl-14-thiomyristic acid (b), [C-11]-S-methyl-12-thiododecanoic acid (c) and [C-11]-palmitate, a showed an early high uptake and a significantly slower late clearance in heart and a prolonged myocardial elimination half-life (30 min). Analysis of heart tissue and urine samples showed that a was metabolized via beta-oxidation in myocardium. Small animal PET images of the accumulation of a in the rat myocardium were clearly superior to [C-11]-palmitate. These initial studies suggest that a could be a potentially useful clinical PET tracer to assess myocardial fatty acid metabolism. (C) 2017 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2017.10.062

文献信息

• [EN] FATTY ACYL AND FATTY ETHER CONJUGATES OF REMDESIVIR AND ITS ACTIVE METABOLITES AS ANTIVIRALS<br/>[FR] CONJUGUÉS D'ACYLE GRAS ET D'ÉTHER GRAS DE REMDÉSIVIR ET SES MÉTABOLITES ACTIFS EN TANT QU'ANTIVIRAUX
  申请人：AJK PHARMACEUTICAL LLC

  公开号：WO2021222807A1

  公开（公告）日：2021-11-04

  Antiviral compounds, pharmaceutical compositions containing the same, and methods of treating viral infections or medical disorders resulting from viral infections are disclosed.

  本发明公开了抗病毒化合物、含有该化合物的药物组合物以及治疗病毒感染或由病毒感染引起的医疗疾病的方法。
• SUBSTITUTED NUCLEOSIDE DERIVATIVES WITH ANTIVIRAL AND ANTIMICROBIAL PROPERTIES
  申请人：Eastern Virginia Medical School

  公开号：EP2175863A2

  公开（公告）日：2010-04-21
• DRUG DELIVERY FROM IMPLANTS USING SELF-ASSEMBLED MONOLAYERS-THERAPEUTIC SAMS
  申请人：Agrawal C. Mauli

  公开号：US20090123516A1

  公开（公告）日：2009-05-14

  Disclosed are medical devices comprising one or more surfaces, one or more SAM molecules attached to the one or more surfaces of the medical device, and one or more therapeutic agents attached to the one or more self-assembled monolayer molecules. Also disclosed are medical devices comprising one or more surfaces, one or more self-assembled monolayer molecules attached to the one or more surfaces of the medical device, one or more linkers comprising a first functional group and a second functional group, the first functional group attached to the self-assembled monolayer molecule and a therapeutic agent attached to the second functional group. The therapeutic agent may be attached to the SAM molecule via a linker. The present invention also concerns methods of administering a therapeutic agent to a subject, comprising contacting the subject with one of the medical devices set forth herein.
• PHOTORECEPTIVE LAYER INCLUDING HETEROGENEOUS DYES AND SOLAR CELL EMPLOYING THE SAME
  申请人：Jung Won-cheol

  公开号：US20120145244A1

  公开（公告）日：2012-06-14

  A photoreceptive layer including heterogeneous dyes is provided. The dye fill density is enhanced and light absorption is achieved at a broad wavelength range, which enables the beneficial utilization of the photoreceptive layer in a dye-sensitized solar cell.
• [EN] ARRAYS OF BIOPOLYMERIC AGENTS AND METHOD FOR THEIR PRODUCTION AND USE<br/>[FR] MATRICES D'AGENTS BIOPOLYMERES ET LEUR PROCEDE DE FABRICATION ET D'UTILISATION
  申请人：CHIRON CORP

  公开号：WO2001001142A2

  公开（公告）日：2001-01-04

  Arrays of biopolymeric binding agents, as well as methods for their fabrication and use, are provided. The subject arrays are characterized having at least two non-modified biopolymeric binding agents, e.g. proteins, nucleic acids, etc., bound to the hydrophilic surface of a spacer layer present a planar surface of a solid support, where the spacer layer at least includes a self-assembled monolayer. The subject arrays find use in a variety of different binding assay applications. Also provided are kits including the subject arrays.