(R)-2-(N,N'-di-tert-butoxycarbonylhydrazino)-5',5'-dimethoxypentanol | 1256461-40-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (R)-2-(N,N'-di-tert-butoxycarbonylhydrazino)-5',5'-dimethoxypentanol
• 英文别名: tert-butyl N-[(2R)-1-hydroxy-5,5-dimethoxypentan-2-yl]-N-[(2-methylpropan-2-yl)oxycarbonylamino]carbamate
• CAS: 1256461-40-1
• 化学式: C₁₇H₃₄N₂O₇
• 分子量: 378.466
• InChiKey: BAZHNQLJPZATDS-GFCCVEGCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  26
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  107
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (R)-2-(N,N'-di-tert-butoxycarbonylhydrazino)-5',5'-dimethoxypentanol 、 叔丁基二苯基氯硅烷 在 咪唑 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 14.0h， 以89%的产率得到(R)-1-tert-butyldiphenylsilyloxy-2-(N,N'-di-tert-butoxycarbonylhydrazino)-5,5-dimethoxypentane
  参考文献：
  名称：

  Organocatalytic asymmetric syntheses of functionalized tetrahydropyridazines

  摘要：

  Four tetrahydropyridazines, respectively, substituted at the C-3 position with hydroxymethyl, a silyloxymethyl, a carboxylic acid, and a methyl ester have been prepared in good yields and high enantiomeric purities using organocatalytic alpha-amination of aldehydes as the key step. These compounds have then been tested as organocatalysts for the same reaction. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2010.07.030
• 作为产物：
  描述：

  (R)-2-(N,N'-di-tert-butoxycarbonylhydrazino)-5,5-dimethoxypentanal 在 sodium tetrahydroborate 、 氯化铵 作用下， 以 乙醇 、 水 为溶剂， 反应 0.25h， 生成 (R)-2-(N,N'-di-tert-butoxycarbonylhydrazino)-5',5'-dimethoxypentanol
  参考文献：
  名称：

  Organocatalytic asymmetric syntheses of functionalized tetrahydropyridazines

  摘要：

  Four tetrahydropyridazines, respectively, substituted at the C-3 position with hydroxymethyl, a silyloxymethyl, a carboxylic acid, and a methyl ester have been prepared in good yields and high enantiomeric purities using organocatalytic alpha-amination of aldehydes as the key step. These compounds have then been tested as organocatalysts for the same reaction. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2010.07.030

文献信息

• Organocatalytic asymmetric syntheses of functionalized tetrahydropyridazines
  作者：Delphine Kalch、Ramzi Ait Youcef、Xavier Moreau、Christine Thomassigny、Christine Greck

  DOI：10.1016/j.tetasy.2010.07.030

  日期：2010.9

  Four tetrahydropyridazines, respectively, substituted at the C-3 position with hydroxymethyl, a silyloxymethyl, a carboxylic acid, and a methyl ester have been prepared in good yields and high enantiomeric purities using organocatalytic alpha-amination of aldehydes as the key step. These compounds have then been tested as organocatalysts for the same reaction. (C) 2010 Elsevier Ltd. All rights reserved.