4-oxo-1,4-dihydrobenzo[g]quinoline-3-carbonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-oxo-1,4-dihydrobenzo[g]quinoline-3-carbonitrile
• 英文别名: 3-cyano-4-oxo-1,4-dihydrobenzo[g]quinoline；4-oxo-1H-benzo[g]quinoline-3-carbonitrile
• 化学式: C₁₄H₈N₂O
• 分子量: 220.23
• InChiKey: PCDYAYPYXXAGOL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  52.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-oxo-1,4-dihydrobenzo[g]quinoline-3-carbonitrile 以 N,N-二甲基甲酰胺 、 三氯氧磷 为溶剂， 以1.89 g (49.5%)的产率得到4-chlorobenzo[g]quinoline-3-carbonitrile
  参考文献：
  名称：

  Tricyclic protein kinase inhibitors

  摘要：

  这项发明提供了具有结构1的化合物，这些化合物可作为蛋白酪氨酸激酶的抑制剂，是抗增殖剂。

  公开号：

  US20010051620A1
• 作为产物：
  描述：

  3-{[(dimethylamino)methylidene]amino}-2-naphthoate 在 正丁基锂 、 溶剂黄146 作用下， 以 四氢呋喃 、 正己烷 、 乙腈 为溶剂， 以3.80 g (67%)的产率得到4-oxo-1,4-dihydrobenzo[g]quinoline-3-carbonitrile
  参考文献：
  名称：

  Tricyclic protein kinase inhibitors

  摘要：

  这项发明提供了具有结构1的化合物，这些化合物可作为蛋白酪氨酸激酶的抑制剂，是抗增殖剂。

  公开号：

  US20010051620A1

文献信息

• Method for the regioselective preparation of substituted benzo[g]quinoline3-carbonitriles and benzo[g]quinazolines
  申请人：American Home Products Corporation

  公开号：US20020091273A1

  公开（公告）日：2002-07-11

  This invention relates to a method for the regioselective synthesis of 4,6,7,8-substituted benzo[g]quinoline-3-carbonitriles and 4,6,7,8-substituted benzo[g]quinazolines as well as intermediates thereof. The compounds derived from this invention are useful for the treatment of a variety of diseases that are a result of deregulation of these PTK's, and more specifically, are anti-cancer agents and are useful for the treatment of cancer in mammals. In addition, the compounds derived from this invention are useful for the treatment of polycystic kidney disease in mammals.

  该发明涉及一种用于选择性合成4,6,7,8-取代苯并[g]喹啉-3-碳腈和4,6,7,8-取代苯并[g]喹唑啉以及它们的中间体的方法。该发明衍生的化合物可用于治疗由这些PTK的失调导致的各种疾病，更具体地说，它们是抗癌剂，可用于治疗哺乳动物的癌症。此外，该发明衍生的化合物可用于治疗哺乳动物的多囊肾病。
• [EN] TRICYCLIC PROTEIN KINASE INHIBITORS<br/>[FR] INHIBITEURS TRICYCLIQUES DE PROTEINE KINASE
  申请人：AMERICAN HOME PROD

  公开号：WO2001047892A1

  公开（公告）日：2001-07-05

  This invention provides compounds of formula (1) which are useful as inhibitors of protein tyrosine kinase and are antiproliferative agents.

  本发明提供了一种式子为(1)的化合物，它们可用作蛋白酪氨酸激酶的抑制剂并具有抗增殖作用。
• Method for the regioselective preparation of substituted benzo[g]quinoline-3-carbonitriles and benzo[g]quinazolines
  申请人：Berger Maarten Dan

  公开号：US20060041127A1

  公开（公告）日：2006-02-23

  This invention relates to a method for the regioselective synthesis of 4,6,7,8-substituted benzo[g]quinoline-3-carbonitriles and 4,6,7,8-substituted benzo[g]quinazolines as well as intermediates thereof. The compounds derived from this invention are useful for the treatment of a variety of diseases that are a result of deregulation of these PTK's, and more specifically, are anti-cancer agents and are useful for the treatment of cancer in mammals. In addition, the compounds derived from this invention are useful for the treatment of polycystic kidney disease in mammals.

  本发明涉及一种4,6,7,8-取代苯并[g]喹啉-3-羧腈和4,6,7,8-取代苯并[g]喹唑啉的区域选择性合成方法及其中间体。本发明所得化合物可用于治疗多种疾病，这些疾病是由这些PTK的失调所致，更具体地说，它们是抗癌剂，可用于治疗哺乳动物的癌症。此外，本发明所得化合物还可用于治疗哺乳动物的多囊肾病。
• METHOD FOR THE REGIOSELECTIVE PREPARATION OF SUBSTITUTED BENZO[G]QUINOLINE-3-CARBONITRILES AND BENZO[G]QUINAZOLINES
  申请人：Berger Dan Maarten

  公开号：US20080171874A1

  公开（公告）日：2008-07-17

  This invention relates to a method for the regioselective synthesis of 4,6,7,8-substituted benzo[g]quinoline-3-carbonitriles and 4,6,7,8-substituted benzo[g]quinazolines as well as intermediates thereof. The compounds derived from this invention are useful for the treatment of a variety of diseases that are a result of deregulation of these PTK's, and more specifically, are anti-cancer agents and are useful for the treatment of cancer in mammals. In addition, the compounds derived from this invention are useful for the treatment of polycystic kidney disease in mammals.

  本发明涉及一种4,6,7,8-取代苯并[g]喹啉-3-碳腈和4,6,7,8-取代苯并[g]喹唑啉的区域选择性合成方法，以及它们的中间体。本发明得到的化合物可用于治疗多种由这些PTK的失调引起的疾病，更具体地说，是抗癌剂，可用于治疗哺乳动物的癌症。此外，本发明得到的化合物还可用于治疗哺乳动物的多囊肾病。
• TRICYCLIC PROTEIN KINASE INHIBITORS
  申请人：Wyeth

  公开号：EP1242382A1

  公开（公告）日：2002-09-25