Retinyl octanoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Retinyl octanoate
• 英文别名: [(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] octanoate
• 化学式: C₂₈H₄₄O₂
• 分子量: 412.6
• InChiKey: AWGMQQGZWRIUJI-UBMBPVGBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.2
• 重原子数：
  30
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  维生素A 、 辛酸酐 生成 Retinyl octanoate
  参考文献：
  名称：

  FURR, HAROLD C.;ZENG, SIHUI;CLIFFORD, ANDREW J.;OLSON, JAMES A., J. CHROMATOGR. BIOMED. APPL., 527,(1990) N, C. 406-413

  摘要：

  DOI：

文献信息

• Chroman derivatives as lipoxygenase inhibitors
  申请人：Zhang Wei

  公开号：US20060193797A1

  公开（公告）日：2006-08-31

  The present invention is concerned with certain novel derivatives of Formula I: wherein X and R 1 to R 10 are as described in the specification, and where either R 5 is OH, —NR d OR a or —NR d —NR b R c , or R 7 is —NR d OR a or —NR d —NR b R c , or C═R 7 R 8 is C═NOR a or C═N—NR b R c , which may be useful in the manufacture of pharmaceutical compositions for treating disorders mediated by lipoxygenases. They may also be useful in the manufacture of skin care and/or pharmaceutical compositions for the treatment of lipoxygenase mediated disorders.

  本发明涉及Formula I的某些新颖衍生物：其中X和R1至R10如规范中所述，其中R5为OH，—NRdORa或—NRd—NRbRc之一，或R7为—NRdORa或—NRd—NRbRc之一，或C═R7R8为C═NORa或C═N—NRbRc，这些可能在制造用于治疗通过脂氧合酶介导的疾病的药物组合物中有用。它们还可能在制造用于治疗脂氧合酶介导疾病的皮肤护理和/或药用组合物中有用。
• Cosmetic composition
  申请人：UNILEVER PLC

  公开号：EP0512814A1

  公开（公告）日：1992-11-11

  Topical compositions for preventing or at least reducing the damaging effects of ultra-violet light on skin comprise 1-hydroxycholecalciferol and/or 1,25 dihydroxycholecalciferol in combination with a sunscreen material and preferably also retinol and/or a derivative thereof. The compositions may also be used for promoting repair of photodamaged skin.

  用于预防或至少减少紫外线对皮肤的损害的局部组合物包括1-羟基胆钙化醇和/或1,25-二羟基胆钙化醇，与防晒材料结合，最好还包括视黄醇和/或其衍生物。该组合物还可用于促进光损伤皮肤的修复。
• Skin care compositions containing dimethyl imidazolidinone and retinol or retinyl ester
  申请人：UNILEVER PLC

  公开号：EP0745375A1

  公开（公告）日：1996-12-04

  Dimethyl imidazolidinone in combination with either retinol or retinyl ester resulted in a synergistic enhancement in keratinocyte proliferation and synergistic inhibition of keratinocyte differentiation. The effects of the retinol or retinyl esters in combination with dimethyl imidazolidinone were analogous to treatment with retinoic acid.

  二甲基咪唑烷酮与视黄醇或视黄醇酯结合使用，可协同促进角质形成细胞的增殖，并协同抑制角质形成细胞的分化。视黄醇或视黄醇酯与二甲基咪唑烷酮结合使用的效果与视黄酸治疗类似。
• Skin care compositions containing a retinoid
  申请人：UNILEVER PLC

  公开号：EP0803247A2

  公开（公告）日：1997-10-29

  Melinamide in combination with retinol or retinyl ester resulted in a synergistic enhancement in keratinocyte proliferation. The effects of the retinol or retinyl esters in combination with melinamide were analogous to treatment with retinoic acid.

  美利那酰胺与视黄醇或视黄酯结合使用可协同增强角质细胞的增殖。视黄醇或视黄醇酯与美利那酰胺结合使用的效果与视黄酸类似。
• EXTERNAL SKIN COMPOSITIONS
  申请人：Kanebo, Limited

  公开号：EP1384482A1

  公开（公告）日：2004-01-28

  The external skin care composition of the present invention comprises N-acetylglucosamine and at least one member selected from the group consisting of retinoid and pro-vitamin A. The external skin care composition of the present invention has an effect of promoting the production of epidermal hyaluronic acid and can retain firmness and moisture of the skin.

  本发明的外用护肤组合物包括 N-乙酰葡糖胺和至少一种选自维甲酸和维生素 A 原的成员。 本发明的外用护肤组合物具有促进表皮透明质酸生成的功效，可保持皮肤的紧致和水分。