十二烷硫酸单酯、三乙醇胺(1:1)的化合物 | 139-96-8

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫酸及其衍生物
• 中文名称: 十二烷硫酸单酯、三乙醇胺(1:1)的化合物
• 中文别名: 月桂醇硫酸酯TEA盐；十二烷基硫酸三乙醇胺(盐)；十二烷基硫酸三乙醇胺；月桂醇硫酸酯 TEA 盐；TL40
• 英文名称: dodecyl sulfate triethanolamine
• 英文别名: Laurylschwefelsaeure*Triethanolamin；Laurylsulfat - Triaethanolamin；tris-(2-hydroxy-ethyl)-amine; dodecyl sulfate；Tris-(2-hydroxy-aethyl)-amin; Dodecylsulfat；tris(2-hydroxyethyl)ammonium decyl sulfate；lauryl sulfate triethanol amine；triethanolamine laureth sulfate；triethanolamine lauryl sulfate；TEA lauryl sulphate；triethanolamine salt of lauryl sulfate；triethanolammonium lauryl sulfate；triethanolamine lauryl sulphate；TEA lauryl sulfate；Dodecyl sulfate;tris(2-hydroxyethyl)azanium
• CAS: 139-96-8
• 化学式: C₆H₁₅NO₃*C₁₂H₂₆O₄S
• 分子量: 415.592
• InChiKey: JZKFHQMONDVVNF-UHFFFAOYSA-N

物化性质

• 密度：
  1.1280 (rough estimate)
• 闪点：
  >100 °C
• LogP：
  5.395 (est)
• 物理描述：
  Dodecyl sulfate, [triethanolamine salt] is a colorless liquid with a mild odor, Sinks and mixes with water. (USCG, 1999)
• 颜色/状态：
  LIQUID OR PASTE

计算性质

• 辛醇/水分配系数(LogP)：
  4.42
• 重原子数：
  27
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  136
• 氢给体数：
  4
• 氢受体数：
  8

ADMET

毒理性

• 人类毒性摘录

由阴离子表面活性剂飞溅污染造成的眼部伤害比阳离子表面活性剂造成的伤害要轻，但可能比非离子表面活性剂造成的疼痛和刺激感更强。/阴离子表面活性剂/

...INJURIES OF EYE RESULTING FROM SPLASH CONTAMINATION WITH ANIONIC SURFACTANTS ARE LESS SERIOUS THAN THOSE FROM CATIONIC, BUT MAY ENTAIL MORE DISCOMFORT & IRRITATION THAN FROM NONIONIC SURFACTANTS. /ANIONIC SURFACTANTS/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

在水中以0.5%-1%的浓度对兔子眼睛进行滴试，通常会导致立即不适、结膜充血、角膜上皮水肿，并且可以通过荧光素点染。一两天内迅速愈合，无浑浊。/阴离子表面活性剂/

...TESTED AT 0.5%-1% CONCN IN WATER BY APPLICATION OF DROP TO RABBIT EYES TYPICALLY HAS CAUSED IMMEDIATE DISCOMFORT, HYPEREMIA OF CONJUNCTIVA, EDEMA OF CORNEAL EPITHELIUM WITH PUNCTATE STAINABILITY BY FLUORESCEIN...PROMPT HEALING IN DAY OR TWO...NO OPACITY. /ANIONIC SURFACTANTS/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

广泛使用低急性及慢性毒性的阴离子洗涤剂。支链产品中的少数...显示出显著的经皮毒性。任何这些物质都可能会引起皮肤刺激。/烷基硫酸钠/

WIDELY USED ANIONIC DETERGENTS OF LOW ACUTE & CHRONIC TOXICITY. FEW OF BRANCHED-CHAIN PRODUCTS...SHOWN...SIGNIFICANT PERCUTANEOUS TOXICITY. SKIN IRRITATION MAY BE ENCOUNTERED WITH ANY OF THESE SUBSTANCES. /ALKYL SODIUM SULFATES/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

TEALS 是在测试表面活性剂化合物对动物（包括感觉反应、疼痛/不适或组织损伤）的刺激性时进行的一项测试。TEALS 在小鼠上呼吸道测试、扭动测试和德雷兹皮肤测试中显示出最大的刺激性。

TEALS WAS AMONG SURFACTANT CMPD TESTED FOR IRRITANCY WITH CRITERIA INCL SENSORY RESPONSE, PAIN/DISCOMFORT OR TISSUE DAMAGE IN ANIMALS. TEALS WAS MOST IRRITATING IN TEST WITH MOUSE UPPER RESP TRACT, WRITHING TESTS & DRAIZE SKIN TEST.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

实验室中有一半评分46%的三乙醇胺月桂硫酸盐作为刺激物，另一半评分它为非刺激物，这是基于对兔子的皮肤刺激性测试。

HALF OF LABORATORIES SCORED 46% AQ TRIETHANOLAMINE LAURYL SULFATE AS IRRITANT & HALF SCORED IT AS NONIRRITANT WITH SKIN IRRITATION TESTS ON RABBITS.

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险品运输编号：
  204kgs
• WGK Germany：
  3
• 海关编码：
  3402190000

制备方法与用途

生产方法：将十三烷醇与硫酸进行酯化反应，然后再用三乙醇胺进行中和，从而得到所需产物。

反应信息

• 作为反应物：
  描述：

  L-精氨酸 、 L-精氨酸盐酸盐 、 十二烷硫酸单酯、三乙醇胺(1:1)的化合物 反应 1.0h， 生成 L-瓜氨酸
  参考文献：
  名称：

  Immobilized catalytically active substance and method of preparing the

  摘要：

  一种酶或微生物被困在硫酸多糖的凝胶基质中（所述多糖分子中含有超过10 w/w％的硫酸基），在氨离子、金属离子、水溶性胺或水混溶性有机溶剂的存在下。因此获得的固定化酶或微生物表现出高水平的催化活性，可长时间使用于连续酶法反应中。

  公开号：

  US04138292A1

文献信息

• [EN] PHENOTHIAZINE DERIVATIVES AND USES THEREOF<br/>[FR] DÉRIVÉS DE PHÉNOTHIAZINE ET LEURS UTILISATIONS
  申请人：CAMP4 THERAPEUTICS CORP

  公开号：WO2019195789A1

  公开（公告）日：2019-10-10

  The present invention provides phenothiazine compounds, processes for their preparation, pharmaceutical compositions comprising the compounds, and the use of the compounds or the compositions in the treatment of various diseases or conditions, for example ribosomal disorders and ribosomopathies, e.g. Diamond Blackfan anemia (DBA).

  本发明提供了吩噻嗪化合物，其制备方法，包含该化合物的药物组合物，以及在治疗各种疾病或症状中使用该化合物或组合物，例如核糖体紊乱和核糖体病，例如钻石-布莱克范贫血（DBA）。
• IONIZABLE CATIONIC LIPID FOR RNA DELIVERY
  申请人：Arcturus Therapeutics, Inc.

  公开号：US20180169268A1

  公开（公告）日：2018-06-21

  What is described is a compound of formula I consisting of a compound in which R 1 is a branched chain alkyl consisting of 10 to 31 carbons; R 2 is a linear alkyl, alkenyl, or alkynyl consisting of 2 to 20 carbons; L 1 and L 2 are the same or different, each a linear alkylene of 1 to 20 carbons or a linear alkenylene of 2 to 20 carbons; X 1 is S or O; R 3 is a linear or branched alkylene consisting of 1 to 6 carbons; and R 4 and R 5 are the same or different, each a hydrogen or a linear or branched alkyl consisting of 1 to 6 carbons; or a pharmaceutically acceptable salt thereof.

  描述的是一种化合物，其化学式为I，包括以下成分： R1为由10至31个碳组成的支链烷基化合物； R2为由2至20个碳组成的直链烷基、烯基或炔基； L1和L2相同或不同，每个为由1至20个碳组成的直链烷基或由2至20个碳组成的直链烯基； X1为S或O； R3为由1至6个碳组成的直链或支链烷基； R4和R5相同或不同，每个为氢或由1至6个碳组成的直链或支链烷基；或其药用可接受盐。
• CONDENSED HETEROCYCLIC COMPOUND
  申请人：Sumitomo Chemical Company, Limited

  公开号：US20180317492A1

  公开（公告）日：2018-11-08

  A condensed heterocyclic compound represented by formula (II), in which Q represents a group represented by formula Q-1 or a group represented by formula Q-2, has an excellent control effect on arthropod pests (wherein, Z represents a nitrogen atom or CX 2 , X 1 and X 2 each independently represent a hydrogen atom, a C1-C6 chain hydrocarbon group optionally having one or more substituent selected from group B, a phenyl group optionally having one or more substituent selected from group C, or the like, A 1 represents NH, NCH 3 , or the like, A 2 represents a nitrogen atom or CH, A 3 represents a nitrogen atom or CR 4 , R 1 represents a C1-C5 perfluoroalkyl group or the like, and n, p, q, and r each independently represent 0, 1, or 2).

  公式（II）所代表的一种缩合杂环化合物，其中Q代表公式Q-1所代表的基团或者公式Q-2所代表的基团，在节肢动物害虫上具有出色的控制效果（其中，Z代表氮原子或CX2，X1和X2分别独立地代表氢原子、一个C1-C6链烃基，可选地具有来自B组的一个或多个取代基，一个苯基，可选地具有来自C组的一个或多个取代基，或类似物，A1代表NH，NCH3，或类似物，A2代表氮原子或CH，A3代表氮原子或CR4，R1代表C1-C5全氟烷基或类似物，n、p、q和r分别独立地代表0、1或2）。
• CONJUGATE-BASED ANTIFUNGAL AND ANTIBACTERIAL PRODRUGS
  申请人：Bapat Abhijit S.

  公开号：US20140364595A1

  公开（公告）日：2014-12-11

  The invention provides conjugate-based antifungal or antibacterial prodrugs formed by coupling at least one anti-fungal agent or antibacterial agent with at least one linker and/or carrier. The prodrugs are of formula: (i) (AFA) m -X-(L) n ; (ii) [(AFA) m′ -X] p -L; (iii) AFA-[X-(L) n′ ] q ; or (iv) (AFA) m″ -X, wherein: AFA is an antifungal agent or an antibacterial agent; L is a carrier; X is a linker; m ranges from 1 to 10; n ranges from 2 to 10; m′ is 1 to 10; p is 1 to 10; n′ is 1 to 10; and q is 1 to 10, provided that q′ and n are not both 1; and m″ is 1 to 10. The invention also provides nanoparticles comprising the conjugate-based prodrugs. Additionally, the invention also provides non-conjugated antifungal and antibacterial agents in the form of nanoparticles.

  该发明提供了由至少一种抗真菌剂或抗菌剂与至少一种连接剂和/或载体偶联形成的基于共轭的抗真菌或抗菌前药。这些前药的公式为：(i) (AFA) m -X-(L) n ; (ii) [(AFA) m′ -X] p -L; (iii) AFA-[X-(L) n′ ] q ; 或 (iv) (AFA) m″ -X，其中：AFA是抗真菌剂或抗菌剂；L是载体；X是连接剂；m范围从1到10；n范围从2到10；m′为1到10；p为1到10；n′为1到10；q为1到10，前提是q'和n不同时为1；m″为1到10。该发明还提供了包含基于共轭的前药的纳米粒子。此外，该发明还提供了以纳米粒子形式的非共轭抗真菌和抗菌剂。
• SILENCING OF POLO-LIKE KINASE EXPRESSION USING INTERFERING RNA
  申请人：PROTIVA BIOTHERAPEUTICS, INC.

  公开号：US20160115483A1

  公开（公告）日：2016-04-28

  The present invention provides compositions comprising interfering RNA (e.g., siRNA, aiRNA, miRNA) that target polo-like kinase 1 (PLK-1) expression and methods of using such compositions to silence PLK-1 expression. More particularly, the present invention provides unmodified and chemically modified interfering RNA molecules which silence PLK-1 expression and methods of use thereof. The present invention also provides serum-stable nucleic acid-lipid particles (e.g., SNALP) comprising an interfering RNA molecule described herein, a cationic lipid, and a non-cationic lipid, which can further comprise a conjugated lipid that inhibits aggregation of particles. The present invention further provides methods of silencing PLK-1 gene expression by administering an interfering RNA molecule described herein to a mammalian subject. The present invention additionally provides methods of identifying and/or modifying PLK-1 interfering RNA having immunostimulatory properties. Methods for sensitizing a cell such as a cancer cell to the effects of a chemotherapy drug comprising sequentially delivering PLK-1 interfering RNA followed by the chemotherapy drug are also provided.

  本发明提供了包含干扰RNA（例如siRNA、aiRNA、miRNA）的组合物，其靶向波洛样激酶1（PLK-1）表达，并提供了使用这种组合物来沉默PLK-1表达的方法。更具体地说，本发明提供了未修饰和化学修饰的干扰RNA分子，这些分子可以沉默PLK-1表达，并提供了它们的使用方法。本发明还提供了含有干扰RNA分子、阳离子脂质和非阳离子脂质的血清稳定核酸-脂质颗粒（例如SNALP），这些颗粒还可以进一步包含抑制颗粒聚集的共轭脂质。本发明还提供了通过向哺乳动物主体施用本文描述的干扰RNA分子来沉默PLK-1基因表达的方法。本发明还提供了识别和/或修改具有免疫刺激性能的PLK-1干扰RNA的方法。此外，还提供了一种通过顺序输送PLK-1干扰RNA后接着化疗药物来使细胞（如癌细胞）对化疗药物产生敏感性的方法。