perthenin acetate | 133411-40-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: perthenin acetate
• 英文别名: [(3aS,6S,6aS,9aS,9bR)-6,9a-dimethyl-3-methylidene-2,9-dioxo-4,5,6,9b-tetrahydro-3aH-azuleno[8,7-b]furan-6a-yl] acetate
• CAS: 133411-40-2
• 化学式: C₁₇H₂₀O₅
• 分子量: 304.343
• InChiKey: MERZCOJSGYMMNO-MIMFBCBLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  69.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  银胶菊宁 、 乙酸酐 在 indium(III) chloride 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 生成 perthenin acetate
  参考文献：
  名称：

  Psilostachyin, acetylated pseudoguaianolides and their analogues: Preparation and evaluation of their anti-inflammatory potential

  摘要：

  Naturally occurring acetylated pseudoguaianolides and psilostachyin including their analogues were synthesized. The structure of semi-synthetic psilostachyin was also confirmed by X-ray crystallography. The anti-inflammatory potential of all the derivatives has been evaluated through in vitro expression of TNF-alpha, IL-1 beta and IL-6 in murine neutrophils. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.06.037

文献信息

• Antimalarial activity of parthenin and its derivatives
  作者：M Hooper、GC Kirby、MM Kulkarni、SN Kulkarni、BA Nagasampagi、MJ O'Neill、JD Phillipson、SR Rojatkar、DC Warhurst

  DOI：10.1016/0223-5234(90)90190-e

  日期：1990.11

  Parthenin and some of its derivatives have been shown to posses significant anti-malarial activity against a multi-drug resistant strain of Plasmodium falciparum. Structure-activity relationships in this series of compounds are discussed and possible mechanisms of action considered. Molecular matching of the oxygen atoms of parthenin and the new anti-malarial drug qinghaosu shows both molecules to be amphipathic with common areas for their oxygen atoms and hydrocarbon frameworks.