(3aR,5aS,9bS)-3a,4,5,5a,6,7-hexahydro-3a-hydroxy-5a,9-dimethyl-3-methylenenaphtho[1,2-b]furan-2,8(3H,9bH)-dione | 144860-23-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (3aR,5aS,9bS)-3a,4,5,5a,6,7-hexahydro-3a-hydroxy-5a,9-dimethyl-3-methylenenaphtho[1,2-b]furan-2,8(3H,9bH)-dione
• 英文别名: (3aR,5aS,9bS)-3a-hydroxy-5a,9-dimethyl-3-methylidene-5,6,7,9b-tetrahydro-4H-benzo[g][1]benzofuran-2,8-dione
• CAS: 144860-23-1
• 化学式: C₁₅H₁₈O₄
• 分子量: 262.306
• InChiKey: JJQNORUJCLAZCD-NWANDNLSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  7-hydroxyfrullanolide 在 sodium chromate(VI) 、 sodium acetate 、 乙酸酐 、 溶剂黄146 作用下， 以 苯 为溶剂， 反应 24.0h， 以24 mg的产率得到(3aR,5aS,9bS)-3a,4,5,5a,6,7-hexahydro-3a-hydroxy-5a,9-dimethyl-3-methylenenaphtho[1,2-b]furan-2,8(3H,9bH)-dione
  参考文献：
  名称：

  7-Hydroxyeudesmanolides from Sphaeranthus indicus

  摘要：

  Two new eudesmanolides, along with one known eudesmanolide and two sesquiterpenoids, cryptomeridiol and 4-epicryptomeridiol, have been isolated from Sphaeranthus indicus. The structures of the new compounds have been established by spectral methods, and in one case by chemical correlation.

  DOI：

  10.1016/0031-9422(92)83492-h

文献信息

• [EN] 7-HYDROXYFRULLANOLIDE AND ITS ANALOGS FOR PREVENTION, CONTROL AND TREATMENT OF METABOLIC DISORDERS<br/>[FR] 7-HYDROXYFRULLANOLIDE ET SES ANALOGUES POUR LA PRÉVENTION, LA MAÎTRISE ET LE TRAITEMENT DE TROUBLES DU MÉTABOLISME.
  申请人：LAILA NUTRACEUTICALS

  公开号：WO2012014216A1

  公开（公告）日：2012-02-02

  The invention discloses biologically active ingredient(s) selected from 7- hydroxyfrullanolide, its analogs, the extract(s) and fraction(s) standardized to 7- hydroxyfrullanolide or its analogs or both or mixtures thereof or their composition(s) for the prevention, control and treatment of one or more obesity, overweight, metabolic syndrome, diabetes and other metabolic disorders or for producing lean body mass in a warm blooded animal in need thereof.

  本发明揭示了从7- 羟基富尔醛内酯、其类似物、提取物和分离物中选择的生物活性成分，这些成分经标准化处理得到7- 羟基富尔醛内酯或其类似物或两者或二者的混合物，或它们的组合物，用于预防、控制和治疗一种或多种肥胖、超重、代谢综合征、糖尿病和其他代谢紊乱，或用于在需要的温血动物中产生瘦体重。
• 7-HYRDROXYFRULLANOLIDE ITS ANALOGS FOR PREVENTION CONTROL AND TREATMENT OF METABOLIC DISORDERS
  申请人：LAILA NUTRACEUTICALS

  公开号：US20130136809A1

  公开（公告）日：2013-05-30

  The invention discloses biologically active ingredient(s) selected from 7-hydroxyfrullanolide, its analogs, the ex-tract(s) and fraction(s) standardized to 7-hydroxyfrullanolide or its analogs or both or mixtures thereof or their composition(s) for the prevention, control and treatment of one or more obesity, overweight, metabolic syndrome, diabetes and other metabolic disorders or for producing lean body mass in a warm blooded animal in need thereof.
• CARRIER SYSTEM FOR PREPARING HERBACEOUS EXTRACTS
  申请人：SISAF LIMITED

  公开号：US20220174952A1

  公开（公告）日：2022-06-09

  A method for stabilizing a bioactive herbaceous extract in a composition comprising silicon particles, the method comprising bringing the bioactive herbaceous extract into contact with the silicon particles, in the presence of at least one non-reducing disaccharide. Also related compositions and methods.
• Rojatkar, Supada R.; Sawaikar, Dilip D.; Nagasampagi, Bhimsen A., Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1994, vol. 33, p. 1203 - 1204
  作者：Rojatkar, Supada R.、Sawaikar, Dilip D.、Nagasampagi, Bhimsen A.

  DOI：——

  日期：——
• 7-Hydroxyeudesmanolides from Sphaeranthus indicus
  作者：Supada R. Rojatkar、Bhimsen A. Nagasampagi

  DOI：10.1016/0031-9422(92)83492-h

  日期：1992.9

  Two new eudesmanolides, along with one known eudesmanolide and two sesquiterpenoids, cryptomeridiol and 4-epicryptomeridiol, have been isolated from Sphaeranthus indicus. The structures of the new compounds have been established by spectral methods, and in one case by chemical correlation.