7-isopropyl-1-methyl-phenanthrene-3-carboxylic acid | 111273-97-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 7-isopropyl-1-methyl-phenanthrene-3-carboxylic acid
• 英文别名: 7-Isopropyl-1-methyl-phenanthren-3-carbonsaeure
• CAS: 111273-97-3
• 化学式: C₁₉H₁₈O₂
• 分子量: 278.351
• InChiKey: JCGAGXOUWKANNE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.12
• 重原子数：
  21.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  37.3
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为产物：
  描述：

  惹烯 在 甲醇 、 二硫化碳 、 三氯化铝 、 sodium hypobromide 作用下， 生成 7-isopropyl-1-methyl-phenanthrene-3-carboxylic acid
  参考文献：
  名称：

  Nyman, Annales Academiae Scientiarum Fennicae, Series A, 1934, vol. 41, # 5, p. 8,40, 44

  摘要：

  DOI：

文献信息

• Predictors and Incidence of Urinary Incontinence in Elderly Canadians With and Without Dementia — A Five-Year Follow Up: The Canadian Study of Health and Aging
  作者：Truls Østbye、Steinar Hunskaar、Elizabeth Sykes

  DOI：10.1017/s0714980800000672

  日期：——

  Based on the national Canadian Study of Health and Aging, the objective of this study was to determine the importance of socio-demographic and medical factors, cognitive and functional status as predictors of the development of urinary incontinence, and to estimate five-year incidence by sex and age group. Participants from the Canadian Study of Health and Aging who underwent a clinical examination in 1992 and were continent for urine at the time were followed up and their continence status was again determined in 1997. Multivariate logistic regression models with daily incontinence and daily or less than daily incontinence as the outcomes were developed separately for male (n = 306) and female (n = 520) survivors. Predictor variables were introduced in the following chunks: socio-demographic factors; cognitive status; functional status, diabetes and stroke. Five-year cumulative incidence of daily and less than daily incontinence by sex and age group was also estimated. Results indicated that the incidence of urinary incontinence was higher in women than in men, and increased by age in both men and women. Especially among men, those in institutions were much more likely to develop urinary incontinence than those in the community. Incontinence increased dramatically with severity of dementia, less so with physical immobility. Diabetes mellitus was related to the development incontinence in men but not in women, prior stroke was related to development of incontinence in both sexes. It is concluded that urinary incontinence is common in older persons, and enquiries about its presence should be part of routine medical and nursing assessment of older persons. Those who develop incontinence commonly have dementia and are physically impaired. The extent of assessment and management should be carefully tailored to each individual patient.

  摘要本研究以加拿大全国健康与老龄化研究为基础，旨在确定社会人口和医疗因素、认知和功能状况对尿失禁发生的重要预测作用，并按性别和年龄组估计五年的发病率。对加拿大健康与老龄化研究（Canadian Study of Health and Aging）中于 1992 年接受临床检查并在当时排尿的参与者进行了跟踪调查，并于 1997 年再次确定了他们的尿失禁状况。分别为男性（306 人）和女性（520 人）幸存者建立了以每日尿失禁和每日或少于每日尿失禁为结果的多变量逻辑回归模型。预测变量分为以下几组：社会人口因素、认知状况、功能状况、糖尿病和中风。此外，还估算了按性别和年龄组分列的每日尿失禁和小于每日尿失禁的五年累计发生率。结果表明，女性尿失禁的发生率高于男性，而且随着年龄的增长，男女尿失禁的发生率均有所上升。尤其是在男性中，住在养老院的人比住在社区的人更容易出现尿失禁。尿失禁随痴呆症的严重程度而急剧增加，但随身体活动不便而增加。糖尿病与男性尿失禁的发生有关，但与女性无关。结论是，尿失禁在老年人中很常见，对老年人进行常规医疗和护理评估时应询问是否存在尿失禁。出现尿失禁的老年人通常患有痴呆症且身体机能受损。评估和处理的程度应根据每位患者的具体情况认真制定。
• Investigations in the Retene Field. V. The Structure of 6-Acetylretene
  作者：David E. Adelson、Marston Taylor Bogert

  DOI：10.1021/ja01295a037

  日期：1936.4
• Effect of focus on verbal working memory: Critical role of the focus word in reading
  作者：Mariko Osaka、Yukiko Nishizaki、Mie Komori、Naoyuki Osaka

  DOI：10.3758/bf03194957

  日期：2002.6

  The effect of focus on working memory was investigated with the reading span test (RST). In two experiments, the span scores and the number of intrusion errors were compared between the focused RST the and the nonfocused RST. Focus word was defined as the most important word for comprehending a sentence. For the focused RST, the target word to be maintained was the focus word for the sentence. In the nonfocused RST, however, the target word was not the focus word for the sentence. The results of both experiments showed that RST span scores were higher for the focused RST than for the nonfocused RST, and intrusion errors were found to increase for the nonfocused RST In Experiment 2, the effect of focus was compared between high-span and low-span subjects. An effect of sentence length was also investigated. The result showed that low-span subjects were more affected than were high-span subjects by whether the word to be remembered was the focus word. The effect of sentence length was not confirmed. These findings suggest that the low-span subjects had deficits in their ability to establish and/or inhibit mental focus when faced with conflict situations in reading.
• Performance Effects of Extended Feeding of Monensin to Eimeria-Challenged Tom Turkeys
  作者：R.H. Wellenreiter、K.L. Watkins、J.D. Trites、K.D. Poe

  DOI：10.1093/japr/9.2.156

  日期：2000.7

  The benefits of extended feeding of monensin beyond the traditional 8-9 wk of age was demonstrated in a trial in which tom turkeys were fed monensin for either 8, 12, or 16 wk of an 18-wk growout in a step-down program. Four anticoccidial programs were valuated in the trial: 1) no anticoccidial; 2) monensin at 75 g/ton for the first 8 wk followed by no anticoccidial; 3) monensin at 75 g/ton for the first 8 wk, reduced to 67 g/ton until 12 wk, followed by no anticoccidial; and 4) monensin at 75 g/ton for the first 8 wk, reduced to 67 g/ton until 12 wk, further reduced to 60 g/ton until 16 wk, followed by no anticoccidial. In the presence of an induced coccidial challenge, turkeys fed monensin for the first 8 wk (treatments 2, 3, and 4) were significantly heavier with improved feed efficiency compared with turkeys not fed monensin. Extended feeding of monensin beyond the traditional 8-9 wk of age (Treatments 3 and 4) resulted in significantly heavier body weights and significantly improved feed efficiency at 18 wk of age.