Butyl 3-(4-methoxyphenyl)-2-methylprop-2-enoate | 183011-14-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: Butyl 3-(4-methoxyphenyl)-2-methylprop-2-enoate
• 英文别名: butyl 3-(4-methoxyphenyl)-2-methylprop-2-enoate
• CAS: 183011-14-5
• 化学式: C₁₅H₂₀O₃
• 分子量: 248.322
• InChiKey: DPRABEOZXCFUGN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-溴苯甲醚 、 甲基丙烯酸丁酯 在 palladium diacetate 、 potassium carbonate 、 2-二苯基磷-2'-甲基联苯 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 以49%的产率得到n-butyl 2-(4-methoxybenzyl)acrylate
  参考文献：
  名称：

  Selective arylation of 1,1-disubstituted olefins using a biphenyl-based phosphine in Heck coupling reactions

  摘要：

  The biphenyl-based phosphine, 2-diphenylphosphino-2'-methylbiphenyl is an effective ligand for palladium-catalyzed terminal arylation of 1,1-disubstituted olefins with aryl bromides in DMF and K2CO3 as base. The yields of products are independent of the electronic properties of the aryl bromides, however, the nature of the olefin has a major effect. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.07.052

文献信息

• A novel catalytic decarbonylative Heck-type reaction and conjugate addition of aldehydes to unsaturated carbonyl compounds
  作者：Luo Yang、Camille A. Correia、Xiangyu Guo、Chao-Jun Li

  DOI：10.1016/j.tetlet.2010.08.040

  日期：2010.10

  A novel rhodium-catalyzed decarbonylative reaction of aldehydes with unsaturated carbonyl compounds was discovered to generate Heck-type reaction product and conjugate addition product.

  发现了一种新的铑与不饱和羰基化合物进行的铑催化的羰基脱羰反应，生成了Heck型反应产物和共轭加成产物。
• Selective arylation of 1,1-disubstituted olefins using a biphenyl-based phosphine in Heck coupling reactions
  作者：Shirin Nadri、Mohammad Joshaghani、Ezzat Rafiee

  DOI：10.1016/j.tetlet.2009.07.052

  日期：2009.9

  The biphenyl-based phosphine, 2-diphenylphosphino-2'-methylbiphenyl is an effective ligand for palladium-catalyzed terminal arylation of 1,1-disubstituted olefins with aryl bromides in DMF and K2CO3 as base. The yields of products are independent of the electronic properties of the aryl bromides, however, the nature of the olefin has a major effect. (C) 2009 Elsevier Ltd. All rights reserved.