((R)-1-Ethyl-2-oxo-cyclopentyl)-acetic acid | 134983-97-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: ((R)-1-Ethyl-2-oxo-cyclopentyl)-acetic acid
• 英文别名: 2-[(1R)-1-ethyl-2-oxocyclopentyl]acetic acid
• CAS: 134983-97-4
• 化学式: C₉H₁₄O₃
• 分子量: 170.208
• InChiKey: JUJNUVSBHYIYFA-SECBINFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  重氮甲烷 、 ((R)-1-Ethyl-2-oxo-cyclopentyl)-acetic acid 生成 ((R)-1-Ethyl-2-oxo-cyclopentyl)-acetic acid methyl ester
  参考文献：
  名称：

  Asymmetric Michael addition of chiral imines to phenylvinylsulfone: Preparation of key chiral building blocks for the synthesis of Aspidosperma and Hunteria alkaloids.

  摘要：

  Addition of chiral imine 8 to phenylvinylsulfone 9 led, after hydrolytic work-up to adduct 11 (91 % stereoselectivity). This derivative has been converted into target cyclopentanones 14 and 16.

  DOI：

  10.1016/s0957-4166(00)82358-7
• 作为产物：
  描述：

  (R)-2-ethyl-2-(2-methoxycarbonylethyl) cyclopentanone 在 四氧化钌 sodium periodate 、 对甲苯磺酸 、 溶剂黄146 作用下， 以 四氢呋喃 、 四氯化碳 、 水 、 苯 为溶剂， 反应 48.0h， 生成 ((R)-1-Ethyl-2-oxo-cyclopentyl)-acetic acid
  参考文献：
  名称：

  Asymmetric Michael addition of chiral imines to phenylvinylsulfone: Preparation of key chiral building blocks for the synthesis of Aspidosperma and Hunteria alkaloids.

  摘要：

  Addition of chiral imine 8 to phenylvinylsulfone 9 led, after hydrolytic work-up to adduct 11 (91 % stereoselectivity). This derivative has been converted into target cyclopentanones 14 and 16.

  DOI：

  10.1016/s0957-4166(00)82358-7

文献信息

• Asymmetric Michael addition of chiral imines to phenylvinylsulfone: Preparation of key chiral building blocks for the synthesis of Aspidosperma and Hunteria alkaloids.
  作者：Jean d'Angelo、Gilbert Revial、Paulo R.R. Costa、Rosane N. Castro、Octavio A.C. Antunes

  DOI：10.1016/s0957-4166(00)82358-7

  日期：1991.1

  Addition of chiral imine 8 to phenylvinylsulfone 9 led, after hydrolytic work-up to adduct 11 (91 % stereoselectivity). This derivative has been converted into target cyclopentanones 14 and 16.