(S)-1-Amino-3-(tert-butyl-dimethyl-silanyloxy)-2-[(3aR,4R,6S,6aS)-6-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxol-4-yl]-propan-2-ol | 198137-97-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (S)-1-Amino-3-(tert-butyl-dimethyl-silanyloxy)-2-[(3aR,4R,6S,6aS)-6-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxol-4-yl]-propan-2-ol
• CAS: 198137-97-2
• 化学式: C₂₄H₅₁NO₅Si₂
• 分子量: 489.844
• InChiKey: CROOYJZXQPXGMN-JPNCOXSSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.88
• 重原子数：
  32.0
• 可旋转键数：
  8.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  83.17
• 氢给体数：
  2.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  (S)-1-Amino-3-(tert-butyl-dimethyl-silanyloxy)-2-[(3aR,4R,6S,6aS)-6-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxol-4-yl]-propan-2-ol 在 盐酸 作用下， 以 乙醇 、 二氯甲烷 、 苯 为溶剂， 反应 2.0h， 生成 1-[(S)-2-((1R,2R,3S,4S)-2,3-Dihydroxy-4-hydroxymethyl-cyclopentyl)-2,3-dihydroxy-propyl]-5-methyl-1H-pyrimidine-2,4-dione
  参考文献：
  名称：

  A synthetic approach to a novel class of enantiopure cyclopentyl carbocyclic nucleosides and related compounds

  摘要：

  A synthetic entry to a novel class of cyclopentyl carbocyclic nucleosides and other functional derivatives, in enantiopure form, is presented. As a structural feature of these compounds, the base-moiety is separated from the carbocyclic ring by a C-2-chain containing a quaternary stereogenic center and additional chemical functions. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(97)00401-1
• 作为产物：
  描述：

  (S)-2-((3aR,4R,6S,6aS)-6-Hydroxymethyl-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxol-4-yl)-3-((R)-1-phenyl-ethylamino)-propane-1,2-diol 在 palladium on activated charcoal 4-二甲氨基吡啶 、 氢气 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 25.0 ℃ 、303.98 kPa 条件下， 反应 27.0h， 生成 (S)-1-Amino-3-(tert-butyl-dimethyl-silanyloxy)-2-[(3aR,4R,6S,6aS)-6-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxol-4-yl]-propan-2-ol
  参考文献：
  名称：

  A synthetic approach to a novel class of enantiopure cyclopentyl carbocyclic nucleosides and related compounds

  摘要：

  A synthetic entry to a novel class of cyclopentyl carbocyclic nucleosides and other functional derivatives, in enantiopure form, is presented. As a structural feature of these compounds, the base-moiety is separated from the carbocyclic ring by a C-2-chain containing a quaternary stereogenic center and additional chemical functions. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(97)00401-1