2-propanoyl-5-benzyloxyphenol | 63411-94-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-propanoyl-5-benzyloxyphenol
• 英文别名: 2-Hydroxy-4-benzyloxypropiophenon；1-(4-benzyloxy-2-hydroxy-phenyl)-propan-1-one；1-(4-Benzyloxy-2-hydroxy-phenyl)-propan-1-on；4'-benzyloxy-2'-hydroxypropiophenone；1-(2-hydroxy-4-phenylmethoxyphenyl)propan-1-one
• CAS: 63411-94-9
• 化学式: C₁₆H₁₆O₃
• 分子量: 256.301
• InChiKey: KYOWJYOUOIVFFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-propanoyl-5-benzyloxyphenol 在 盐酸 、 potassium carbonate 、 溶剂黄146 、 丙酮 作用下， 生成 1-(4-hydroxy-2-methoxyphenyl)-1-propanone
  参考文献：
  名称：

  Beer et al., Journal of the Chemical Society, 1954, p. 3672,3675

  摘要：

  DOI：
• 作为产物：
  描述：

  2,4-二羟基苯丙酮 、 氯化苄 在 potassium carbonate 、 丙酮 作用下， 生成 2-propanoyl-5-benzyloxyphenol
  参考文献：
  名称：

  Beer et al., Journal of the Chemical Society, 1954, p. 3672,3675

  摘要：

  DOI：

文献信息

• Aromatic urea derivatives and their use as herbicide
  申请人：Mitsui Petrochemical Industries, Ltd.

  公开号：US04838924A1

  公开（公告）日：1989-06-13

  This invention relates to novel compounds of formula [I], a process for their production, and their use as a herbicide. ##STR1## wherein A represents the bond ##STR2## in which X is a hydrogen atom, a chlorine atom, a nitro group or a trifluoromethyl group; B represents a hydrogen atom, a methyl group or a methoxy group; and Ar represents one member selected from the group consisting of ##STR3## in which R.sup.1 to R.sup.38, are as defined hereinafter.

  这项发明涉及公式[I]的新化合物，其生产过程以及它们作为除草剂的用途。其中A代表键##STR2##其中X是氢原子、氯原子、硝基团或三氟甲基基团；B代表氢原子、甲基基团或甲氧基基团；Ar代表从##STR3##中选择的一个成员，其中R.sup.1到R.sup.38如下所定义。
• 2-acetylphenol analogs as potent reversible monoamine oxidase inhibitors
  作者：Lesetja Legoabe、Jacobus Petzer、Anél Petzer

  DOI：10.2147/dddt.s86225

  日期：——

  Based on a previous report that substituted 2-acetylphenols may be promising leads for the design of novel monoamine oxidase (MAO) inhibitors, a series of C5-substituted 2-acetylphenol analogs (15) and related compounds (two) were synthesized and evaluated as inhibitors of human MAO-A and MAO-B. Generally, the study compounds exhibited inhibitory activities against both MAO-A and MAO-B, with selectivity for the B isoform. Among the compounds evaluated, seven compounds exhibited IC50 values <0.01 mu M for MAO-B inhibition, with the most selective compound being 17,000-fold selective for MAO-B over the MAO-A isoform. Analyses of the structure-activity relationships for MAO inhibition show that substitution on the C5 position of the 2-acetylphenol moiety is a requirement for MAO-B inhibition, and the benzyloxy substituent is particularly favorable in this regard. This study concludes that C5-substituted 2-acetylphenol analogs are potent and selective MAO-B inhibitors, appropriate for the design of therapies for neurodegenerative disorders such as Parkinson's disease.
• Mullaji; Shah, Proceedings - Indian Academy of Sciences, Section A, 1951, vol. 34, p. 88,94
  作者：Mullaji、Shah

  DOI：——

  日期：——
• NOVEL UREA DERIVATIVES, PROCESSES FOR PRODUCTION THEREOF AND HERBICIDE
  申请人：MITSUI PETROCHEMICAL INDUSTRIES, LTD.

  公开号：EP0230475B1

  公开（公告）日：1992-03-18
• US4838924A
  申请人：——

  公开号：US4838924A

  公开（公告）日：1989-06-13