(2R,3S)-3-((S)-1-Allyloxycarbonyl-2-methyl-propylcarbamoyl)-2-{(2S,3R)-2-[((R)-4-tert-butoxycarbonylamino-4-methoxycarbonyl-butyryl)-methyl-amino]-3-hydroxy-butyrylamino}-butyric acid methyl ester | 223923-70-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2R,3S)-3-((S)-1-Allyloxycarbonyl-2-methyl-propylcarbamoyl)-2-{(2S,3R)-2-[((R)-4-tert-butoxycarbonylamino-4-methoxycarbonyl-butyryl)-methyl-amino]-3-hydroxy-butyrylamino}-butyric acid methyl ester
• 英文别名: methyl (2R,3S)-2-[[(2S,3R)-3-hydroxy-2-[[(4R)-5-methoxy-4-[(2-methylpropan-2-yl)oxycarbonylamino]-5-oxopentanoyl]-methylamino]butanoyl]amino]-3-methyl-4-[[(2S)-3-methyl-1-oxo-1-prop-2-enoxybutan-2-yl]amino]-4-oxobutanoate
• CAS: 223923-70-4
• 化学式: C₃₀H₅₀N₄O₁₂
• 分子量: 658.747
• InChiKey: GOMLXCYPFXEUAW-ZRBUYWKDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  46
• 可旋转键数：
  22
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  216
• 氢给体数：
  4
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  (2R,3S)-3-((S)-1-Allyloxycarbonyl-2-methyl-propylcarbamoyl)-2-{(2S,3R)-2-[((R)-4-tert-butoxycarbonylamino-4-methoxycarbonyl-butyryl)-methyl-amino]-3-hydroxy-butyrylamino}-butyric acid methyl ester 在 N-甲基吗啉 、 4-二甲氨基吡啶 、 四(三苯基膦)钯 、 5,5-二甲基-1,3-环己二酮 、 N,N-二异丙基乙胺 、 N,N'-二环己基碳二亚胺 、 三氟乙酸 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 140.0h， 生成 dimethyl (2S,5R,6S,9S,12S,13S,16R)-2-[(1R)-1-hydroxyethyl]-12-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dienyl]-1,6,13-trimethyl-3,7,10,14,19-pentaoxo-9-propan-2-yl-1,4,8,11,15-pentazacyclononadecane-5,16-dicarboxylate
  参考文献：
  名称：

  Total Synthesis of Motuporin and 5-[l-Ala]-Motuporin

  摘要：

  Total synthesis of the cyclic peptide hepatotoxin motuporin is described, including an efficient synthesis of the constituent amino acid Adda. Three strategies to motuporin are outlined with their relative strengths and weaknesses. Cyclization of the linear peptide precursor was found to proceed moderately well for peptides containing the N-methyldehydrobutyrine residue masked as a threonine, but significant C-terminal epimerization occurred in the presence of the dehydroamino acid. Replacement of the N-methyldehydrobutyrine residue by L-alanine was explored to assess the contribution of this dehydroamino acid to the biochemical activity of motuporin. Some epimerization also was observed during cyclization of the alanine-containing peptide. Synthetic motuporin and both isomers of 5-[L-Ala]-motuporin inhibit the activity of protein phosphatase-l (PP1) in rat adipocyte lysates with comparable IC50 values. These results indicate that the N-methyldehydrobutyrine residue is not essential for PP1 inhibition.

  DOI：

  10.1021/jo982145i
• 作为产物：
  描述：

  N-Boc-D-γ-glutamyl-(α-methyl ester)-N-methyl-O-benzyl-L-threonine trimethylsilylethyl ester 在 palladium on activated charcoal 2,3,5-三甲基吡啶 、 四丁基氟化铵 、 氢气 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 四氢呋喃 、 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 25.0 ℃ 、101.33 kPa 条件下， 反应 26.0h， 生成 (2R,3S)-3-((S)-1-Allyloxycarbonyl-2-methyl-propylcarbamoyl)-2-{(2S,3R)-2-[((R)-4-tert-butoxycarbonylamino-4-methoxycarbonyl-butyryl)-methyl-amino]-3-hydroxy-butyrylamino}-butyric acid methyl ester
  参考文献：
  名称：

  Total Synthesis of Motuporin and 5-[l-Ala]-Motuporin

  摘要：

  Total synthesis of the cyclic peptide hepatotoxin motuporin is described, including an efficient synthesis of the constituent amino acid Adda. Three strategies to motuporin are outlined with their relative strengths and weaknesses. Cyclization of the linear peptide precursor was found to proceed moderately well for peptides containing the N-methyldehydrobutyrine residue masked as a threonine, but significant C-terminal epimerization occurred in the presence of the dehydroamino acid. Replacement of the N-methyldehydrobutyrine residue by L-alanine was explored to assess the contribution of this dehydroamino acid to the biochemical activity of motuporin. Some epimerization also was observed during cyclization of the alanine-containing peptide. Synthetic motuporin and both isomers of 5-[L-Ala]-motuporin inhibit the activity of protein phosphatase-l (PP1) in rat adipocyte lysates with comparable IC50 values. These results indicate that the N-methyldehydrobutyrine residue is not essential for PP1 inhibition.

  DOI：

  10.1021/jo982145i