7,16-Bis[(5-chloro-8-methoxyquinolin-2-yl)methyl]-2-(prop-2-enoxymethyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane | 849905-44-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7,16-Bis[(5-chloro-8-methoxyquinolin-2-yl)methyl]-2-(prop-2-enoxymethyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane
• 英文别名: 7,16-bis[(5-chloro-8-methoxyquinolin-2-yl)methyl]-2-(prop-2-enoxymethyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane
• CAS: 849905-44-8
• 化学式: C₃₈H₄₈Cl₂N₄O₇
• 分子量: 743.728
• InChiKey: PDRISWJJWCMHNR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  51
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  96.9
• 氢给体数：
  0
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  7,16-Bis[(5-chloro-8-methoxyquinolin-2-yl)methyl]-2-(prop-2-enoxymethyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane 、 二甲基乙氧基硅烷 在 PtCl₆*H₂O 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 3.0h， 生成 、 3-[[7,16-Bis[(5-chloro-8-methoxyquinolin-2-yl)methyl]-1,4,10,13-tetraoxa-7,16-diazacyclooctadec-2-yl]methoxy]propyl-ethoxy-dimethylsilane
  参考文献：
  名称：

  Efficient Immobilization of a Cadmium Chemosensor in a Thin Film:  Generation of a Cadmium Sensor Prototype

  摘要：

  The development of an ion-selective chemosensor for Cd2+ allows generation of a "real-time" sensor, Immobilization of the chemosensor on quartz was achieved in a simple monolayer and in a thin film using a polymer intermediary. As intended, the thin film contains much more chemosensor than the monolayer and provides measurable responses to aqueous Cd2+ concentrations below 1 mu M. Alkali and alkaline earth ions do not interfere with Cd2+ sensing; Zn2+ and Cu2+ are potential interferents.

  DOI：

  10.1021/ol050027t
• 作为产物：
  描述：

  1,8-二氨基-3,6-二氧杂辛烷 在 碳酸氢钠 、 sodium carbonate 作用下， 以 乙腈 为溶剂， 反应 60.0h， 生成 7,16-Bis[(5-chloro-8-methoxyquinolin-2-yl)methyl]-2-(prop-2-enoxymethyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane
  参考文献：
  名称：

  Efficient Immobilization of a Cadmium Chemosensor in a Thin Film:  Generation of a Cadmium Sensor Prototype

  摘要：

  The development of an ion-selective chemosensor for Cd2+ allows generation of a "real-time" sensor, Immobilization of the chemosensor on quartz was achieved in a simple monolayer and in a thin film using a polymer intermediary. As intended, the thin film contains much more chemosensor than the monolayer and provides measurable responses to aqueous Cd2+ concentrations below 1 mu M. Alkali and alkaline earth ions do not interfere with Cd2+ sensing; Zn2+ and Cu2+ are potential interferents.

  DOI：

  10.1021/ol050027t

文献信息

• Efficient Immobilization of a Cadmium Chemosensor in a Thin Film:  Generation of a Cadmium Sensor Prototype
  作者：R. Todd Bronson、David J. Michaelis、Randy D. Lamb、Ghaleb A. Husseini、Paul B. Farnsworth、Matthew R. Linford、Reed M. Izatt、Jerald S. Bradshaw、Paul B. Savage

  DOI：10.1021/ol050027t

  日期：2005.3.1

  The development of an ion-selective chemosensor for Cd2+ allows generation of a "real-time" sensor, Immobilization of the chemosensor on quartz was achieved in a simple monolayer and in a thin film using a polymer intermediary. As intended, the thin film contains much more chemosensor than the monolayer and provides measurable responses to aqueous Cd2+ concentrations below 1 mu M. Alkali and alkaline earth ions do not interfere with Cd2+ sensing; Zn2+ and Cu2+ are potential interferents.