1-(4-硝基苯基)-1,2,3-丙三醇 | 2207-68-3

• 物质功能分类: 有机原料 - 烃类化合物及其衍生物 - 烃类硝化物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-(4-硝基苯基)-1,2,3-丙三醇
• 中文别名: 1-(4-硝基苯基)甘油；1-(对硝基苯)甘油
• 英文名称: 1-(4-nitrophenyl)glycerol
• 英文别名: 1-(4-Nitrophenyl)propane-1,2,3-triol
• CAS: 2207-68-3
• 化学式: C₉H₁₁NO₅
• mdl: MFCD00017037
• 分子量: 213.19
• InChiKey: IUZVZBIQZKBWCC-UHFFFAOYSA-N

物化性质

• 熔点：
  98-101 °C(lit.)
• 沸点：
  353.17°C (rough estimate)
• 密度：
  1.3707 (rough estimate)
• 稳定性/保质期：

  避免让氧化物和酸氯化物接触。

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  107
• 氢给体数：
  3
• 氢受体数：
  5

安全信息

• 危险品标志：
  Xi
• 危险类别码：
  R36/37/38
• WGK Germany：
  3
• 海关编码：
  2906299090
• 安全说明：
  S26,S36,S37/39

制备方法与用途

用途

1-(4-硝基苯基)-1,2,3-丙三醇可作为药物中间体，用于制备含有氨基磺酸盐的化合物，并可用于合成抗惊厥药、抗生素以及抗肿瘤药。

反应信息

• 作为反应物：
  描述：

  1-(4-硝基苯基)-1,2,3-丙三醇 在 盐酸 作用下， 以 水 、 乙腈 为溶剂， 反应 13.03h， 生成 2,3-dihydroxy-3-(4-nitrophenyl)propyl sulfamate
  参考文献：
  名称：

  N-(tert-Butoxycarbonyl)-N-[(triethylenediammonium)sulfonyl]azanide: A Convenient Sulfamoylation Reagent for Alcohols

  摘要：

  A convenient and efficient procedure is described for the sulfamoylation of alcohols using N-(tertbutoxycarbonyl)-N-[(triethylenediammonium)sulfonyl]azanide (1). The ambient temperature stable reagent 1 reacts with phenols as well as primary and secondary alcohols to give high to modest yields. The relative reaction rate of substrates was determined (primary > phenol > secondary tertiary). The reagent's utility as a selective sulfamoylation reagent with polyols is also demonstrated.

  DOI：

  10.1021/ol3009683
• 作为产物：
  描述：

  1-(4-硝基苯基)丙-2-烯-1-醇 在 吡啶 、 potassium osmate(VI) dihydrate 、 甲基磺酰胺 、 potassium carbonate 、 potassium hexacyanoferrate(III) 作用下， 以 水 、 叔丁醇 为溶剂， 反应 48.0h， 以73%的产率得到1-(4-硝基苯基)-1,2,3-丙三醇
  参考文献：
  名称：

  α-乙烯基和α-烯基苄基醇的串联苯甲酰氧化/二羟基化

  摘要：

  甲从头的串联苄氧化二羟基α -vinyl-和α -alkenylbenzyl醇已被开发，得到α，β -dihydroxypropiophenones（= 2,3-二羟基-1-苯基丙-1-酮）和α，β -dihydroxyalkyl苯酮。该方法显示出对底物有选择性，并且对苯甲醇的氧化具有特异性。

  DOI：

  10.1002/hlca.201400143

文献信息

• Image making medium
  申请人：——

  公开号：US20030035917A1

  公开（公告）日：2003-02-20

  The invention relates to an image support medium for creation of an aesthetic image that is an work or object for display. This support medium includes a polymer in an amount sufficient to enable the image to have at least one aesthetic element. In different embodiments, the image support medium is an image support stabilizer, the polymer is a synthetic absorbent or conductive polymer, or the polymer is a transparent or synthetic translucent polymer and a property of this transparent or translucent polymer is enhanced to facilitate the creation or preservation of the image by at least one stabilizer. The invention also relates to a method for preparing this image support medium. The method includes forming a reaction mixture comprising a monomer in an amount sufficient to provide or enable the image to have an aesthetic element, and processing the reaction mixture into a 2- or 3-dimensional shape.

  本发明涉及一种图像支持介质，用于创建作为作品或展示对象的美学图像。这种支撑介质包括一种聚合物，其用量足以使图像具有至少一种审美元素。在不同的实施例中，图像支持介质是一种图像支持稳定剂，聚合物是一种合成的吸收性或导电性聚合物，或者聚合物是一种透明或合成的半透明聚合物，并且这种透明或半透明聚合物的特性被至少一种稳定剂增强，以促进图像的创建或保存。本发明还涉及一种制备这种图像支持介质的方法。该方法包括形成由单体组成的反应混合物，其用量足以提供或使图像具有美学元素，并将反应混合物加工成 2 维或 3 维形状。
• Carbohydrate−Carbohydrate Interactions in Water with Glycophanes as Model Systems
  作者：Juan Carlos Morales、Dácil Zurita、Soledad Penadés

  DOI：10.1021/jo9807823

  日期：1998.12.1

  The synthesis and conformational properties of glycophanes 2 and 3 (cyclodextrin-cyclophane hybrid receptors containing two maltose units linked by (4-hydroxymethyl) benzoic acid spacer) are described. The binding properties in water of these receptors with a series of 4-nitrophenyl glycosides with alpha- and beta-configurations at the anomeric center have been studied using H-1 NMR spectroscopy and molecular mechanics calculations. A comparison of these properties with those of glycophane 1 (an alpha,alpha-trehalose containing glycophane) and alpha-cyclodextrin (alpha CD) using the same glycosides shows the existence of a stabilizing contribution to the free energy of binding in the case of of glycophanes but not in the case of the alpha CD system. This contribution is due to carbohydrate - carbohydrate interactions between both host and guest lipophilic sugar surfaces. Glycophanes 1, 2, and 3 show similar alpha/beta selectivity on binding the ligands, despite the great flexibility of 3 related to 1 and 2. Parallels are drawn between the thermodynamic behavior of these model systems and that proposed for sugar-protein interactions.
• CROSSLINKED POLED POLYMERS FOR NONLINEAR OPTIC APPLICATIONS AND METHOD OF MAKING THEM
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0583417A1

  公开（公告）日：1994-02-23
• METHOD AND COMPOSITION FOR DETECTING BACTERIAL CONTAMINATION IN FOOD PRODUCTS
  申请人：BioControl Systems, Inc.

  公开号：EP0870054B1

  公开（公告）日：2008-07-30
• SENSOR FOR LOCATING WITHIN A URINARY DRAINAGE BAG
  申请人：The University Of Bath

  公开号：EP3746013A1

  公开（公告）日：2020-12-09