3-hydroxyimino-oleanen-(12)-al-(28)-oxime | 69930-63-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3-hydroxyimino-oleanen-(12)-al-(28)-oxime
• 英文别名: 3-Hydroxyimino-oleanen-(12)-al-(28)-oxim
• CAS: 69930-63-8
• 化学式: C₃₀H₄₈N₂O₂
• 分子量: 468.723
• InChiKey: UTWJSQGRKFHTDM-CHMVMOPFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.08
• 重原子数：
  34.0
• 可旋转键数：
  1.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  65.18
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  高根二醇 在 chromium(VI) oxide 、 溶剂黄146 作用下， 生成 3-hydroxyimino-oleanen-(12)-al-(28)-oxime
  参考文献：
  名称：

  SOCIOECONOMIC COSTS OF RHEUMATIC DISEASES Implications for Technology Assessment

  摘要：

  Objectives: To study the socioeconomic impact of rheumatic illness in Sweden and to discuss the consequences for technology assessment studies.Methods: A cost-of-illness study based on data from official statistics and treatment studies.Results: The total socioeconomic cost was 52 billion Swedish kronor (SEK) in 1994. The imbalance between direct (10% of total) and indirect costs (90effectiveness of the healthcare sector, the need for new treatment methods, appropriate information systems, and technology assessment studies as well as the institutional arrangements for rehabilitation and basic medical research.Conclusions: A discussion of solutions for financial cooperation between county councils and regional social insurance offices should be considered. The new biotechnological pharmaceuticals will increase the cost for drugs in health care about 20 times, but the total socioeconomic cost for society may remain at the same level due to a decrease of inpatient costs and indirect costs for loss of production as well as a decrease of transfer payments from social insurance. It is unavoidable that the new pharmaceuticals require priority discussions and active resource allocation in health care and in other sectors of society.

  DOI：

  10.1017/s0266462300103228

文献信息

• Synthesis of nitrogen-containing oleanolic acid derivatives as carbonic anhydrase and acetylcholinesterase inhibitors
  作者：Halil Şenol、Gurbet Çelik Turgut、Alaattin Şen、Rüya Sağlamtaş、Salih Tuncay、İlhami Gülçin、Gülaçtı Topçu

  DOI：10.1007/s00044-023-03031-z

  日期：2023.4

  NMR and HRMS analyses were carried out to determine of structures of all the synthesized molecules. The inhibitory effects of the synthesized compounds on acetylcholinesterase (AChE), human carbonic anhydrase I (hCA I) and II (hCA II) were evaluated. Compounds 13 and 15 showed better inhibitory activity than the other compounds against both hCA I and hCA II isoenzymes, which are competing with AZA

  在这项研究中，从天然三萜类化合物齐墩果酸 (OA) 开始合成了总共 13 种化合物(5 – 17) 。五种新化合物（10、11、12、15和17）是该研究的主要目标，它们在本工作中首次合成为 OA 的肟、亚胺和腙衍生物。其他化合物以前是以天然或半合成的形式获得的。进行 NMR 和 HRMS 分析以确定所有合成分子的结构。评估了合成化合物对乙酰胆碱酯酶 (AChE)、人碳酸酐酶 I (hCA I) 和 II (hCA II) 的抑制作用。化合物13和15对与 AZA 竞争的 hCA I 和 hCA II 同工酶表现出比其他化合物更好的抑制活性。此外，化合物15在所有受试化合物中表现出最强的AChE抑制活性，IC 50值为34.46 µM。