(3aR,4R,5R,7S,8S,9R,9aS,12R)-5-hydroxy-2-(hydroxymethylene)-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-8-yl formate | 257939-39-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (3aR,4R,5R,7S,8S,9R,9aS,12R)-5-hydroxy-2-(hydroxymethylene)-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-8-yl formate
• CAS: 257939-39-2
• 化学式: C₂₂H₃₂O₅
• 分子量: 376.493
• InChiKey: PGEUTVKEZUSTQG-BKUNHTPHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.57
• 重原子数：
  27.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  83.83
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  (3aR,4R,5R,7S,8S,9R,9aS,12R)-5-hydroxy-2-(hydroxymethylene)-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-8-yl formate 在 对甲苯磺酰叠氮 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以44.1%的产率得到(3aR,4R,5R,7S,8S,9R,9aS,12R)-2-diazo-5-hydroxy-3a,4,7,9,12-pentamethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-8-yl formate
  参考文献：
  名称：

  Synthesis and antibacterial activity of C-2(S)-substituted pleuromutilin derivatives

  摘要：

  In order to probe the effect of C-2(S)-substituted groups in the antibacterial activity. a series of novel C-2(S)-substituted pleuromutilin analogues of SB-225586 were synthesized and evaluated for then in vitro antibacterial activity. The results of antibacterial activities indicated that C-2(S)-substituted pleuromutilin derivatives retained appreciable antibacterial activity, and the 2-fluorination compounds 6a and 6b are more potent than the corresponding 2-hydroxylation analogues 7a and 7b. (C) 2010 Yu She Yang Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved

  DOI：

  10.1016/j.cclet.2010.01.001