S-(-)-2-fluoroheptanol | 110500-31-7

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代醇
• 英文名称: S-(-)-2-fluoroheptanol
• 英文别名: (S)-2-fluoro-1-heptanol；(2S)-2-fluoroheptan-1-ol
• CAS: 110500-31-7
• 化学式: C₇H₁₅FO
• 分子量: 134.194
• InChiKey: UEBHTEIKXIPNGN-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  S-(-)-2-fluoroheptanol 在 三乙烯二胺 、 氯化亚砜 、 硝酸 、 sodium acetate 、 sodium hydride 作用下， 以 溶剂黄146 、 苯 为溶剂， 生成 (S)-2-Fluoro-heptanoic acid 4-(5-dodecyl-pyrimidin-2-yl)-phenyl ester
  参考文献：
  名称：

  Nakamura, S.; Nohira, H., Molecular Crystals and Liquid Crystals (1969-1991), 1990, vol. 185, p. 199 - 207

  摘要：

  DOI：
• 作为产物：
  描述：

  (R)-(+)-1,2-环氧庚烷 在 氟化氢吡啶 作用下， 以 乙醚 为溶剂， 以32%的产率得到S-(-)-2-fluoroheptanol
  参考文献：
  名称：

  Nohira, H.; Nakamura, S.; Kamei, M., Molecular Crystals and Liquid Crystals (1969-1991), 1990, vol. 180, p. 379 - 388

  摘要：

  DOI：

文献信息

• Optically active silacyclohexane compounds, liquid crystal compositions
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：US05730902A1

  公开（公告）日：1998-03-24

  An optically active silacyclohexane compound of the formula (I) ##STR1## wherein R represents an organic residue, X represents --CH.sub.2 -- or --O--; Z represents a chiral group having at least one chiral carbon atom; L.sub.1 and L.sub.2 independently represent H or F, n is 0 or 1; ##STR2## represents a trans-1-sila-1,4-cyclohexylene group or trans-4-sila-1,4-cyclohexylene group whose silicon atom at the 1 or 4 position has H, F, Cl or CH.sub.3, or a 1,4-cyclohexylene group; and ##STR3## represents a trans-1-sila-1,4-cyclohexylene group or trans-4-sila-1,4-cyclohexylene group whose silicon atom at the 1 or 4 position has H, F, Cl or CH.sub.3, a 1,4-cyclohexylene group or a 1,4-phenylene group provided that at least one of ##STR4## represents the trans-1-sila-1,4-cyclohexylene group or trans-4-sila-1,4-cyclohexylene group defined above. A liquid crystal composition comprising the compound defined above and a liquid crystal display device comprising the composition are also described.

  公式（I）表示的是一种光学活性的硅杂环己烷化合物，其中R代表有机残基，X代表-CH.sub.2-或-O-; Z代表具有至少一个手性碳原子的手性基团; L.sub.1和L.sub.2分别表示H或F，n为0或1; ##STR2##表示具有H、F、Cl或CH.sub.3的1或4位硅原子的顺-1-硅-1,4-环己基或顺-4-硅-1,4-环己基或1,4-环己基; 和##STR3##表示具有H、F、Cl或CH.sub.3的1或4位硅原子的顺-1-硅-1,4-环己基或顺-4-硅-1,4-环己基或1,4-环己基或1,4-苯基，前提是至少有一个##STR4##表示上述定义的顺-1-硅-1,4-环己基或顺-4-硅-1,4-环己基。还描述了一种包含上述化合物的液晶组合物和包含该组合物的液晶显示装置。
• Analogs of terpene trilactones from ginkgo biloba and related compounds and uses thereof
  申请人：Stromgaard Kristian

  公开号：US20070098632A1

  公开（公告）日：2007-05-03

  The subject invention provides compounds having the structure: wherein R 1 is H, OH, a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety; R 2 is H, OH, a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety; R 3 is H or OH; R 4 is H, OH, a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety; and wherein at least one of R 1 , R 2 , R 3 , or R 4 is a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety, or an optically pure enantiomer of the compound or wherein R1 is H or OH; R2 is H, OH, halogen, unsubstituted or substituted, straight or branched (C 1 -C 5 ) alkyl group, (C 2 -C 5 ) alkenyl, or a (C 2 -C 5 ) alkynyl, (C 1 -C 5 ) alkoxy, (C 2 -C 5 ) alkenyloxy, or (C 2 -C 5 ) alkynyloxy, —N3, —COR5, —CONR5R6, —CO2R5, —OCOR5, —NH(OH), —NR5R6, —NHCOR5, —N(OH)COR5, —CH2OR5, —OCH2CO2R5, —CH2SR5, —CH2NR5R6, —SR5, —OSR5, or —NR5SO2R6, where R5 and R6 are each independently hydrogen, substituted or unsubstituted (C 1 -C 5 ) alkyl, (C 2 -C 5 ) alkenyl, or (C 2 -C 5 ) alkynyl, or a cycloalkyl or aryl group having 3 to 10 carbon atoms; R3 is H or OH; R4 is H, (C1-C10) alkyl, (C1-C10) alkenyl, (C1-C10) alkynyl, -A-Ar, -A-Z-Ar, —SO 2 —Ar, or -A-NR 5 , or —R 7 , where A, Z and Ar are as defined herein, and the use of the compounds for detecting or identifying a receptor which binds the compounds of the invention or for treating a PAF associated condition in a subject.

  该发明涉及具有以下结构的化合物：其中R1为H，OH，光活性基团，荧光基团或放射性基团；R2为H，OH，光活性基团，荧光基团或放射性基团；R3为H或OH；R4为H，OH，光活性基团，荧光基团或放射性基团；且其中至少一个R1，R2，R3或R4为光活性基团，荧光基团或放射性基团，或该化合物的光学纯对映体，或其中R1为H或OH；R2为H，OH，卤素，未取代或取代，直链或支链（C1-C5）烷基，（C2-C5）烯基或（C2-C5）炔基，（C1-C5）烷氧基，（C2-C5）烯氧基或（C2-C5）炔氧基，-N3，-COR5，-CONR5R6，-CO2R5，-OCOR5，-NH（OH），-NR5R6，-NHCOR5，-N（OH）COR5，-CH2OR5，-OCH2CO2R5，-CH2SR5，-CH2NR5R6，-SR5，-OSR5或-NR5SO2R6，其中R5和R6各自独立地为氢，取代或未取代的（C1-C5）烷基，（C2-C5）烯基或（C2-C5）炔基，或具有3至10个碳原子的环烷基或芳基；R3为H或OH；R4为H，（C1-C10）烷基，（C1-C10）烯基，（C1-C10）炔基，-A-Ar，-A-Z-Ar，-SO2-Ar或-A-NR5，或-R7，其中A，Z和Ar如本文所定义，并且使用这些化合物用于检测或识别结合该发明化合物的受体或用于治疗与PAF相关的疾病。
• A ferroelectric liquid-crystalline polymeric composition
  申请人：IDEMITSU KOSAN COMPANY LIMITED

  公开号：EP0310081A2

  公开（公告）日：1989-04-05

  The liquid-crystalline polymeric composition of the invention comprises (A) a non-liquid-crystalline polymeric compound and (B) a low-molecular liquid-crystalline compound each having a proton donor and/or a proton acceptor in the molecular structure and the low-molecular compound has a chiral smectic C phase. By virtue of these functional groups forming hydrogen bonds between the components, the liquid-crystalline polymeric composition of the invention is not a mere blend of the components liable to cause phase separation but is imparted with greatly increased stability and uniformity of the blend as well as responsivity of high speed.

  本发明的液晶聚合物组合物包括(A)非液晶聚合物化合物和(B)低分子液晶化合物，每种化合物的分子结构中都有质子供体和/或质子受体，且低分子化合物具有手性 Smectic C 相。由于这些官能团在各组分之间形成氢键，本发明的液晶聚合物组合物不再是容易导致相分离的单纯组分混合物，而是大大提高了混合物的稳定性和均匀性以及高速响应性。
• Optically active silacyclohexane compounds, liquid crystal compositions comprising the same and liquid crystal display devices comprising the compositions
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：EP0761674A1

  公开（公告）日：1997-03-12

  An optically active silacyclohexane compound of the formula (I) wherein R is an organic residue, X is -CH2- or -O-; Z is a group which has at least one chiral carbon atom; L1 and L2 are independently H or F, n is 0 or 1; is a 1,4-cyclohexylene group or a trans-1-sila-1,4-cyclohexylene or trans-4-sila-1,4-cyclohexylene group wherein the silicon atom at the 1 or 4 position, respectively, is substituted by H, F, Cl, or CH3; is a 1,4-cyclohexylene group, a 1,4-phenylene group or a trans-1-sila-1,4-cyclohexylene or trans-4-sila-1,4-cyclohexylene group wherein the silicon atom at the 1 or 4 position, respectively, is substituted by H, F, Cl or CH3 provided that at least one of is a trans-1-sila-1,4-cyclohexylene or trans-4-sila-1,4-cyclohexylene group as defined above. A liquid crystal composition comprising the compound and a liquid crystal display device comprising the composition are also described.

  式（I）的光学活性硅环己烷化合物 其中 R 是有机残基，X 是-CH2-或-O-；Z 是至少有一个手性碳原子的基团；L1 和 L2 独立地是 H 或 F，n 是 0 或 1； 是1,4-环己烯基团或反式-1-硅杂-1,4-环己烯或反式-4-硅杂-1,4-环己烯基团，其中位于1或4位的硅原子分别被H、F、Cl或CH3取代； 是 1,4-环己烯基团、1,4-亚苯基基团或反式-1-硅杂-1,4-环己烯基团或反式-4-硅杂-1,4-环己烯基团，其中 1 位或 4 位的硅原子分别被 H、F、Cl 或 取代，条件是其中至少有一个 是如上定义的反式-1-硅杂-1,4-环己烯基团或反式-4-硅杂-1,4-环己烯基团。此外，还描述了包含该化合物的液晶组合物和包含该组合物的液晶显示装置。
• US4988460A
  申请人：——

  公开号：US4988460A

  公开（公告）日：1991-01-29