decyl(-6)Glc(a1-2b)Fruf | 1447967-67-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: decyl(-6)Glc(a1-2b)Fruf
• 英文别名: (2R,3S,4S,5R,6R)-2-(decoxymethyl)-6-[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxyoxane-3,4,5-triol
• CAS: 1447967-67-0
• 化学式: C₂₂H₄₂O₁₁
• 分子量: 482.569
• InChiKey: XHZRBKUSOJTCBR-ZQNATQRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  33
• 可旋转键数：
  15
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  179
• 氢给体数：
  7
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  癸基溴 、 蔗糖 在 吡啶 、 三苯基氯甲烷 、 四丁基溴化铵 、 溴甲苯 、 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 decyl(-6)Glc(a1-2b)Fruf 、 (2R,3R,4S,5S,6R)-2-(((2S,3S,4S,5R)-5-((decyloxy)methyl)-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
  参考文献：
  名称：

  Self-Assembling Properties of 6-O- and 6′-O-Alkylsucrose Mixtures Having Different Chain Lengths Under Aqueous Conditions

  摘要：

  The self-assembling properties of the 6-O- and 6-O-alkylsucrose mixtures with different chain lengths including octyl, decyl, dodecyl, and tetradecyl under aqueous conditions were studied and compared with those of the 6-O- and 6-O-hexadecylsucrose mixture previously reported. The title compounds were synthesized from sucrose in five steps. The results of scanning and transmission electron microscopes, powder X-ray diffraction, and dynamic light scattering measurements indicated that the self-assembling properties of octyl, decyl, and dodecyl derivatives were completely different from those of the 6-O- and 6-O-hexadecylsucrose mixture. The three derivatives reported here primarily formed lamellar planes, which further induced the formation of vesicle-type particles under aqueous conditions, whereas the previous derivatives primarily formed spherical micelles in water, which further assembled according to face-centered cubic organization by a drying process from the aqueous dispersion. It was also found that the 6-O- and 6-O-tetradecylsucrose mixture showed concentration-induced micelle-lamellar transition behavior in an aqueous dispersion. Furthermore, the mixing of a regioisomer, 6-O-hexadecylsucrose, with 6-O-hexadecylsucrose induced different self-assembling properties from that of 6-O-hexadecylsucrose alone, but this effect did not appear in the self-assembling of the 6-O- and 6-O-octylsucrose mixture.

  DOI：

  10.1080/07328303.2013.809094

文献信息

• Acylated Exendin-4 Compounds
  申请人：Lau Jesper

  公开号：US20090318353A1

  公开（公告）日：2009-12-24

  This invention provides new therapeutic peptides, i.e. new protracted Exendin-4 compounds, pharmaceutical compositions and the use of such.

  本发明提供了新的治疗性肽，即新的长效Exendin-4化合物、药物组合物及其用途。
• Long-Acting Y2 and/or Y4 Receptor Agonists
  申请人：Østergaard Søren

  公开号：US20110275559A1

  公开（公告）日：2011-11-10

  The present invention relates to a PYY or PP peptide derivative or analogue thereof derivatised with one or more serum albumin binding side chains comprising a dis-tal tetrazole or carboxylic acid group. Moreover, the invention relates to compositions hereof and methods of treatment of conditions responsive to Y receptor modulation.

  本发明涉及一种与一种或多种血清白蛋白结合侧链衍生物或类似物衍生物化合的PYY或PP肽衍生物，其中包括一个远端四唑基或羧酸基团。此外，本发明涉及这些组合物以及对于对Y受体调节敏感的病况的治疗方法。
• PROTEASE STABILIZED, ACYLATED INSULIN ANALOGUES
  申请人：Madsen Peter

  公开号：US20110105720A1

  公开（公告）日：2011-05-05

  Novel acylated insulin analogues exhibiting resistance towards proteases can, effectively, be administered pulmonary or orally. The insulin analogues contain B25H and A14E or A14H.

  具有对蛋白酶抵抗力的新型酰化胰岛素类似物可以通过肺部或口服有效地给予。胰岛素类似物包含B25H和A14E或A14H。
• PROTEASE STABILIZED ACYLATED INSULIN ANALOGUES
  申请人：NOVO NORDISK A/S

  公开号：US20150210748A1

  公开（公告）日：2015-07-30

  Novel acylated insulin analogues exhibiting resistance towards proteases can, effectively, be administered pulmonary or orally. The insulin analogues contain B25H and A14E or A14H.

  具有对蛋白酶抗性的新型酰化胰岛素类似物可以有效地通过肺部或口服给药。胰岛素类似物包含B25H和A14E或A14H。
• Pharmaceutical compositions for pulmonary or nasal delivery of peptides
  申请人：NOVO NORDISK A/S

  公开号：EP2060268A1

  公开（公告）日：2009-05-20

  The invention relates to pharmaceutical compositions for pulmonary or nasal delivery of an amylin peptide and an insulin peptide

  本发明涉及用于肺部或鼻腔输送淀粉肽和胰岛素肽的药物组合物