(4aR,6R,6aS,7R,8S,9R,11aS,11bS)-8-(hydroxymethyl)-6-methoxy-4,4-dimethyldodecahydro-1H-6,11b-(epoxymethano)-6a,9-methanocyclohepta[a]naphthalen-7-ol | 1215081-16-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (4aR,6R,6aS,7R,8S,9R,11aS,11bS)-8-(hydroxymethyl)-6-methoxy-4,4-dimethyldodecahydro-1H-6,11b-(epoxymethano)-6a,9-methanocyclohepta[a]naphthalen-7-ol
• CAS: 1215081-16-5
• 化学式: C₂₁H₃₄O₄
• 分子量: 350.499
• InChiKey: ODUDEEWCHPGARP-ASPONPPBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.96
• 重原子数：
  25.0
• 可旋转键数：
  2.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  58.92
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  (4aR,6R,6aS,7R,8S,9R,11aS,11bS)-8-(hydroxymethyl)-6-methoxy-4,4-dimethyldodecahydro-1H-6,11b-(epoxymethano)-6a,9-methanocyclohepta[a]naphthalen-7-ol 在 2,2,6,6-tetramethyl-piperidine-N-oxyl 、 N-氯代丁二酰亚胺 、 四丁基氯化铵 作用下， 以 二氯甲烷 为溶剂， 以76%的产率得到(4aR,6R,6aS,7R,8R,9R,11aS,11bS)-7-hydroxy-6-methoxy-4,4-dimethyldodecahydro-1H-6,11b-(epoxymethano)-6a,9-methanocyclohepta[a]naphthalene-8-carbaldehyde
  参考文献：
  名称：

  Formal synthesis of semiaquilegin A

  摘要：

  A formal synthesis of semiaquilegin A is achieved starting from readily available oridonin in 19 linear steps. The absolute configuration of the natural product has been established. A variety of useful analogues were prepared through this synthetic route. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.12.118
• 作为产物：
  描述：

  甲醇 、 ((4aR,6R,6aS,7R,8S,9R,11aS,11bS)-6,7-dihydroxy-4,4-dimethyldodecahydro-1H-6,11b-(epoxymethano)-6a,9-methanocyclohepta[a]naphthalen-8-yl)methyl acetate 、 乙酰氯 反应 4.0h， 以85%的产率得到(4aR,6R,6aS,7R,8S,9R,11aS,11bS)-8-(hydroxymethyl)-6-methoxy-4,4-dimethyldodecahydro-1H-6,11b-(epoxymethano)-6a,9-methanocyclohepta[a]naphthalen-7-ol
  参考文献：
  名称：

  Formal synthesis of semiaquilegin A

  摘要：

  A formal synthesis of semiaquilegin A is achieved starting from readily available oridonin in 19 linear steps. The absolute configuration of the natural product has been established. A variety of useful analogues were prepared through this synthetic route. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.12.118