(1S)-1-[4-[tris[4-[(1S)-1-hydroxypropyl]phenyl]methyl]phenyl]propan-1-ol | 1246306-15-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (1S)-1-[4-[tris[4-[(1S)-1-hydroxypropyl]phenyl]methyl]phenyl]propan-1-ol
• CAS: 1246306-15-9
• 化学式: C₃₇H₄₄O₄
• 分子量: 552.754
• InChiKey: PGOOELYMZJCRSL-ZYADHFCISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  41
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  80.9
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-[三(4-甲酰基苯基)甲基]苯甲醛 、 diethylzinc 在 (S_p,S)-5-[C₆H₁₁-CH(Me)-N=C(Me)]-4-OH-[2.2]paracyclophane 作用下， 以 甲苯 为溶剂， 反应 72.0h， 以29%的产率得到(1S)-1-[4-[tris[4-[(1S)-1-hydroxypropyl]phenyl]methyl]phenyl]propan-1-ol
  参考文献：
  名称：

  Asymmetric synthesis of chiral tectons with tetrapodal symmetry: fourfold asymmetric reactions

  摘要：

  The diastereoselective fourfold addition to Ellman-type imines furnished after deprotection the tetrapodal amines in excellent yields. The unprecedented asymmetric fourfold addition of hydride and alkylzinc reagents to tetrapodal ketones and aldehydes, respectively, is achieved by employing CBS-reduction or [2.2]paracyclophane-based ketimine ligands with good to excellent global enantiomeric ratios. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2010.05.018

文献信息

• Asymmetric synthesis of chiral tectons with tetrapodal symmetry: fourfold asymmetric reactions
  作者：Oliver Plietzsch、Christine Inge Schilling、Martin Nieger、Thierry Muller、Stefan Bräse

  DOI：10.1016/j.tetasy.2010.05.018

  日期：2010.6

  The diastereoselective fourfold addition to Ellman-type imines furnished after deprotection the tetrapodal amines in excellent yields. The unprecedented asymmetric fourfold addition of hydride and alkylzinc reagents to tetrapodal ketones and aldehydes, respectively, is achieved by employing CBS-reduction or [2.2]paracyclophane-based ketimine ligands with good to excellent global enantiomeric ratios. (C) 2010 Elsevier Ltd. All rights reserved.