2-Chloro-4-methoxy-3-(methoxymethoxy)pyridine | 1261584-76-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Chloro-4-methoxy-3-(methoxymethoxy)pyridine
• 英文别名: 2-chloro-4-methoxy-3-(methoxymethoxy)pyridine
• CAS: 1261584-76-2
• 化学式: C₈H₁₀ClNO₃
• 分子量: 203.625
• InChiKey: QBRIHWQJDHXFDV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-Chloro-4-methoxy-3-(methoxymethoxy)pyridine 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 反应 0.83h， 生成 2-chloropyridine-3,4-diol
  参考文献：
  名称：

  First synthesis of 4-chloro-2,2-difluoro[1,3]dioxole[4,5-c]pyridine

  摘要：

  The 2,2-difluorobenzodioxole moiety has been introduced in medicinal chemistry research as a potential metabolically more stable derivative of the benzodioxole fragment. Herein we present, to the best of our knowledge, the first synthesis of 4-chloro-2,2-difluoro[1,3]dioxole[4,5-c]pyridine, a 5-aza-derivative of the 2,2-difluorobenzodioxole, from simple and cheap starting materials. The chlorine atom in position 4 could be useful for further functionalisation by cross coupling reactions. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.10.119
• 作为产物：
  描述：

  4-甲氧基-3-甲氧基甲氧基吡啶 在 正丁基锂 、 六氯乙烷 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 3.0h， 以61%的产率得到2-Chloro-4-methoxy-3-(methoxymethoxy)pyridine
  参考文献：
  名称：

  First synthesis of 4-chloro-2,2-difluoro[1,3]dioxole[4,5-c]pyridine

  摘要：

  The 2,2-difluorobenzodioxole moiety has been introduced in medicinal chemistry research as a potential metabolically more stable derivative of the benzodioxole fragment. Herein we present, to the best of our knowledge, the first synthesis of 4-chloro-2,2-difluoro[1,3]dioxole[4,5-c]pyridine, a 5-aza-derivative of the 2,2-difluorobenzodioxole, from simple and cheap starting materials. The chlorine atom in position 4 could be useful for further functionalisation by cross coupling reactions. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.10.119

文献信息

• First synthesis of 4-chloro-2,2-difluoro[1,3]dioxole[4,5-c]pyridine
  作者：Maria Pia Catalani、Alfredo Paio、Lorenzo Perugini

  DOI：10.1016/j.tetlet.2010.10.119

  日期：2010.12

  The 2,2-difluorobenzodioxole moiety has been introduced in medicinal chemistry research as a potential metabolically more stable derivative of the benzodioxole fragment. Herein we present, to the best of our knowledge, the first synthesis of 4-chloro-2,2-difluoro[1,3]dioxole[4,5-c]pyridine, a 5-aza-derivative of the 2,2-difluorobenzodioxole, from simple and cheap starting materials. The chlorine atom in position 4 could be useful for further functionalisation by cross coupling reactions. (C) 2010 Elsevier Ltd. All rights reserved.