(2R,5R,6S,8R,9R)-6-Benzyloxy-8,9-dihydroxy-3,13,20-trioxa-tricyclo[13.2.2.1^2,5]icosa-1(18),15(19),16-trien-14-one | 211692-18-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2R,5R,6S,8R,9R)-6-Benzyloxy-8,9-dihydroxy-3,13,20-trioxa-tricyclo[13.2.2.1^2,5]icosa-1(18),15(19),16-trien-14-one
• 英文别名: (2R,5R,6S,8R,9R)-8,9-dihydroxy-6-phenylmethoxy-3,13,20-trioxatricyclo[13.2.2.12,5]icosa-1(18),15(19),16-trien-14-one
• CAS: 211692-18-1
• 化学式: C₂₄H₂₈O₇
• 分子量: 428.482
• InChiKey: RHOHWYQVWSUABP-WKKMNAASSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  31
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  94.4
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (2R,5R,6S,8R,9R)-6-Benzyloxy-8,9-dihydroxy-3,13,20-trioxa-tricyclo[13.2.2.1^2,5]icosa-1(18),15(19),16-trien-14-one 在 palladium on activated charcoal 氢气 、 4-甲基苯磺酸吡啶 作用下， 以 二氯甲烷 、 乙酸乙酯 为溶剂， 生成 4-Methyl-benzoic acid 3-[(4R,5R)-5-((R)-1,2-dihydroxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-propyl ester
  参考文献：
  名称：

  Ansa Macrolides as Molecular Workbenches: Stereocontrolledsyn Additions toE olefins

  摘要：

  Fixed on an aromatic platform in a conformationally defined way, acyclic (E)-alkenes can be considered gripped on a molecular workbench. The olefinic ansa-macrolides formed in this way are shielded on one face. On epoxidation and dihydroxylation [Eq. (1)] the attack on the double bond takes place diastereoselectively from outside the ring, and the ansa chain can subsequently be cleaved from the workbench by mild hydrogenolysis. Bn=benzyl, NMO=N-methylmorpholin-N-oxide.

  DOI：

  10.1002/(sici)1521-3773(19980619)37:11<1566::aid-anie1566>3.0.co;2-u
• 作为产物：
  描述：

  (3S,4R)-3-O-benzyl-4,5-O-isopropylidene-3,4,5-trihydroxypentanal 在 4-二甲氨基吡啶 、 lithium hydroxide 、 四氧化锇 、 lithium aluminium tetrahydride 、 N-甲基吲哚酮 、 4 A molecular sieve 、 2,4,6-三氯苯甲酰氯 、 水 、 对甲苯磺酸 、 溶剂黄146 、 丙酸 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 丙酮 、 甲苯 为溶剂， 反应 36.0h， 生成 (2R,5R,6S,8R,9R)-6-Benzyloxy-8,9-dihydroxy-3,13,20-trioxa-tricyclo[13.2.2.1^2,5]icosa-1(18),15(19),16-trien-14-one
  参考文献：
  名称：

  Ansa Macrolides as Molecular Workbenches: Stereocontrolledsyn Additions toE olefins

  摘要：

  Fixed on an aromatic platform in a conformationally defined way, acyclic (E)-alkenes can be considered gripped on a molecular workbench. The olefinic ansa-macrolides formed in this way are shielded on one face. On epoxidation and dihydroxylation [Eq. (1)] the attack on the double bond takes place diastereoselectively from outside the ring, and the ansa chain can subsequently be cleaved from the workbench by mild hydrogenolysis. Bn=benzyl, NMO=N-methylmorpholin-N-oxide.

  DOI：

  10.1002/(sici)1521-3773(19980619)37:11<1566::aid-anie1566>3.0.co;2-u

文献信息

• Ansa Macrolides as Molecular Workbenches: Stereocontrolledsyn Additions toE olefins
  作者：Johann Mulzer、Karin Schein、Jan W. Bats、Jürgen Buschmann、Peter Luger

  DOI：10.1002/(sici)1521-3773(19980619)37:11<1566::aid-anie1566>3.0.co;2-u

  日期：1998.6.19

  Fixed on an aromatic platform in a conformationally defined way, acyclic (E)-alkenes can be considered gripped on a molecular workbench. The olefinic ansa-macrolides formed in this way are shielded on one face. On epoxidation and dihydroxylation [Eq. (1)] the attack on the double bond takes place diastereoselectively from outside the ring, and the ansa chain can subsequently be cleaved from the workbench by mild hydrogenolysis. Bn=benzyl, NMO=N-methylmorpholin-N-oxide.