(6S,9S,11E,15R)-9-[(2R,3R,4S)-4-chloro-3-hydroxy-4-phenylbutan-2-yl]-15-[(3-chloro-4-methoxyphenyl)methyl]-6-(2-methylpropyl)-5,8-dioxa-14,17-diazaspiro[2.15]octadec-11-ene-4,7,13,16-tetrone | 223764-03-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 英文名称: (6S,9S,11E,15R)-9-[(2R,3R,4S)-4-chloro-3-hydroxy-4-phenylbutan-2-yl]-15-[(3-chloro-4-methoxyphenyl)methyl]-6-(2-methylpropyl)-5,8-dioxa-14,17-diazaspiro[2.15]octadec-11-ene-4,7,13,16-tetrone
• CAS: 223764-03-2
• 化学式: C₃₆H₄₄Cl₂N₂O₈
• 分子量: 703.66
• InChiKey: PNZLTIGTYFXMMM-TXJYCBAHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  48
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  140
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  (6S,9S,11E,15R)-9-[(2R,3R,4S)-4-chloro-3-hydroxy-4-phenylbutan-2-yl]-15-[(3-chloro-4-methoxyphenyl)methyl]-6-(2-methylpropyl)-5,8-dioxa-14,17-diazaspiro[2.15]octadec-11-ene-4,7,13,16-tetrone 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 生成 (6S,9S,11E,15R)-15-[(3-chloro-4-methoxyphenyl)methyl]-6-(2-methylpropyl)-9-[(1S)-1-[(2R,3R)-3-phenyloxiran-2-yl]ethyl]-5,8-dioxa-14,17-diazaspiro[2.15]octadec-11-ene-4,7,13,16-tetrone
  参考文献：
  名称：

  Synthesis and biological evaluation of cryptophycin analogs with substitution at C-6 (fragment C region)

  摘要：

  Analogs of the antitumor agents cryptophycins 1 and 8 with dialkyl substitution at C-6 (fragment C) were synthesized and evaluated for in vitro cytotoxicity against human leukemia cells (CCRF-CEM). The activity of these analogs decreased as the size of the substituents at C-6 increased. The C-6 spirocylopropyl compound (2g) was highly potent in vitro and showed excellent antitumor activity in animal models. (C) 1999 Elsevier Science Ltd. ALI rights reserved.

  DOI：

  10.1016/s0960-894x(98)00748-3
• 作为产物：
  描述：

  1-氰基-1-环丙烷羧酸 在 Adam’s catalyst 吗啉 、 2-羟基吡啶 、 甲醇 、 4-二甲氨基吡啶 、 sodium hydroxide 、 四(三苯基膦)钯 、 三甲基氯硅烷 、 氢气 、 溶剂黄146 、 间氯过氧苯甲酸 、 N,N'-二环己基碳二亚胺 、 三氟乙酸 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 二氯甲烷 、 氯仿 、 甲苯 为溶剂， 生成 (6S,9S,11E,15R)-9-[(2R,3R,4S)-4-chloro-3-hydroxy-4-phenylbutan-2-yl]-15-[(3-chloro-4-methoxyphenyl)methyl]-6-(2-methylpropyl)-5,8-dioxa-14,17-diazaspiro[2.15]octadec-11-ene-4,7,13,16-tetrone
  参考文献：
  名称：

  Synthesis and biological evaluation of cryptophycin analogs with substitution at C-6 (fragment C region)

  摘要：

  Analogs of the antitumor agents cryptophycins 1 and 8 with dialkyl substitution at C-6 (fragment C) were synthesized and evaluated for in vitro cytotoxicity against human leukemia cells (CCRF-CEM). The activity of these analogs decreased as the size of the substituents at C-6 increased. The C-6 spirocylopropyl compound (2g) was highly potent in vitro and showed excellent antitumor activity in animal models. (C) 1999 Elsevier Science Ltd. ALI rights reserved.

  DOI：

  10.1016/s0960-894x(98)00748-3

文献信息

• Synthesis and biological evaluation of cryptophycin analogs with substitution at C-6 (fragment C region)
  作者：David L. Varie、Chuan Shih、David A. Hay、Sherri L. Andis、Tom H. Corbett、Lynn S. Gossett、Samantha K. Janisse、Michael J. Martinelli、Eric D. Moher、Richard M. Schultz、John E. Toth

  DOI：10.1016/s0960-894x(98)00748-3

  日期：1999.2

  Analogs of the antitumor agents cryptophycins 1 and 8 with dialkyl substitution at C-6 (fragment C) were synthesized and evaluated for in vitro cytotoxicity against human leukemia cells (CCRF-CEM). The activity of these analogs decreased as the size of the substituents at C-6 increased. The C-6 spirocylopropyl compound (2g) was highly potent in vitro and showed excellent antitumor activity in animal models. (C) 1999 Elsevier Science Ltd. ALI rights reserved.