3-bromo-7-fluoro-6-methoxy-8-methylquinoline | 1170991-83-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-bromo-7-fluoro-6-methoxy-8-methylquinoline
• 英文别名: 3-Bromo-7-fluoro-6-methoxy-8-methyl-quinoline
• CAS: 1170991-83-9
• 化学式: C₁₁H₉BrFNO
• 分子量: 270.101
• InChiKey: PILKNNOXSYHACL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-bromo-7-fluoro-6-methoxy-8-methylquinoline 在 氢溴酸 作用下， 反应 20.0h， 以63%的产率得到3-bromo-7-fluoro-8-methylquinolin-6-ol
  参考文献：
  名称：

  2,2,3-Tribromopropanal as a Versatile Reagent in the Skraup-Type Synthesis of 3-Bromoquinolin-6-ols

  摘要：

  2,2,3-Tribromopropanal, a reagent which almost became forgotten in the chemical literature after its first application in the 1950s, is used for the one-step transformation of diversely substituted 4-nitro- and 4-methoxyanilines into 3-bromo-6-nitroquinolines and 3-bromo-6-methoxyquinolines. These intermediates are then converted, in one further step, into 3-bromoquinolin-6-ols, which may carry additional substituents at positions 7 and 8.

  DOI：

  10.1055/s-0033-1340670
• 作为产物：
  描述：

  2,2,3-三溴丙醛 、 3-氟-4-甲氧基-2-甲基苯胺 在 溶剂黄146 、 Ammonium hydroxide 作用下， 以 水 、 溶剂黄146 为溶剂， 反应 1.0h， 生成 3-bromo-7-fluoro-6-methoxy-8-methylquinoline
  参考文献：
  名称：

  [EN] QUINOLINE DERIVATIVES AND THEIR USE AS FUNGICIDES
  [FR] FONGICIDES

  摘要：

  公开号：

  WO2009087098A8

文献信息

• QUINOLINE DERIVATIVES AND THEIR USE AS FUNGICIDES
  申请人：Murphy Kessabi Fiona

  公开号：US20100280068A1

  公开（公告）日：2010-11-04

  Compounds of the general Formula (1) wherein the substituents are as defined in claim 1 , are useful as fungicides.

  通式（1）中所述的化合物，其中取代基如权利要求1所定义，可用作杀真菌剂。
• Quinoline derivatives and their use as fungicides
  申请人：Murphy Kessabi Fiona

  公开号：US08415272B2

  公开（公告）日：2013-04-09

  Compounds of the general Formula (1) wherein the substituents are as defined in claim 1, are useful as fungicides.

  通式（1）中，取代基如权利要求1所定义的化合物，可用作杀真菌剂。
• US8415272B2
  申请人：——

  公开号：US8415272B2

  公开（公告）日：2013-04-09
• [EN] FUNGICIDES<br/>[FR] FONGICIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2009087098A2

  公开（公告）日：2009-07-16

  Compounds of the general Formula (1) wherein the substituents are as defined in claim 1, are useful as fungicides.
• 2,2,3-Tribromopropanal as a Versatile Reagent in the Skraup-Type Synthesis of 3-Bromoquinolin-6-ols
  作者：Clemens Lamberth、Fiona Kessabi、Renaud Beaudegnies、Laura Quaranta、Stephan Trah、Guillaume Berthon、Fredrik Cederbaum、Thomas Vettiger、CS Prasanna

  DOI：10.1055/s-0033-1340670

  日期：——

  2,2,3-Tribromopropanal, a reagent which almost became forgotten in the chemical literature after its first application in the 1950s, is used for the one-step transformation of diversely substituted 4-nitro- and 4-methoxyanilines into 3-bromo-6-nitroquinolines and 3-bromo-6-methoxyquinolines. These intermediates are then converted, in one further step, into 3-bromoquinolin-6-ols, which may carry additional substituents at positions 7 and 8.