28-norolean-17-en-3β-ol | 4748-12-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 28-norolean-17-en-3β-ol
• 英文别名: (3S,4aR,6aR,6aR,6bR,14aR,14bR)-4,4,6a,6b,11,11,14b-heptamethyl-2,3,4a,5,6,6a,7,8,9,10,12,13,14,14a-tetradecahydro-1H-picen-3-ol
• CAS: 4748-12-3
• 化学式: C₂₉H₄₈O
• 分子量: 412.7
• InChiKey: BYIIDRHXMCRKPL-UKCDONGNSA-N

物化性质

• 熔点：
  303-304 °C
• 沸点：
  487.4±44.0 °C(Predicted)
• 密度：
  1.02±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.1
• 重原子数：
  30
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  28-norolean-17-en-3β-ol 在 五氯化磷 、 Petroleum ether 作用下， 生成 28-nor-5(4=>3)-abeo-oleanadiene-(3.17)
  参考文献：
  名称：

  Winterstein; Stein, Justus Liebigs Annalen der Chemie, 1933, vol. 502, p. 223,234

  摘要：

  DOI：
• 作为产物：
  描述：

  (3beta)-3-羟基-齐墩果-18-烯-28-酸 生成 28-norolean-17-en-3β-ol
  参考文献：
  名称：

  60.三萜。第一部分：叶酸，一种新的三萜类皂苷元

  摘要：

  DOI：

  10.1039/jr9510000257

文献信息

• Hemodialysis-associated hypertension: Pathophysiology and therapy
  作者：Matthias P. Hörl、Walter H. Hörl

  DOI：10.1053/ajkd.2002.30542

  日期：2002.2

  The majority of end-stage renal disease (ESRD) patients are hypertensive. Hypertension in the hemodialysis patient population is multifactorial. Further, hypertension is associated with an increased risk for left ventricular hypertrophy, coronary artery disease, congestive heart failure, cerebrovascular complications, and mortality. Anti hypertensive medications alone do not adequately control blood pressure (BP) in hemodialysis patients. There are, however, several therapeutic options available to normalize BP in these patients, often without the need for additional drug therapy (eg, long, slow hemodialysis; short, daily hemodialysis; nocturnal hemodialysis; or, most effectively, dietary salt and fluid restriction in combination with reduction of dialysate sodium concentration). Optimal BP in dialysis patients is not different from recommendations for the general population, even though definite evidence is not yet available. Predialysis systolic and diastolic BPs are of particular importance. Left ventricular mass correlates with predialysis systolic BP. Survival is better in hemodialysis patients with a mean arterial pressure below 99 mm Hg as compared with those with higher BP. Low predialysis systolic BP (<110 mm Hg) and low predialysis diastolic BP (<70 mm Hg) are associated with increased mortality, primarily because of severe congestive heart failure or coronary artery disease. Patients that experience repeated intradialytic hypotensive episodes should also be viewed with caution, and predialytic BP values should be reevaluated. A possible treatment option for these patients may be slow, long hemodialysis; short, daily hemodialysis; or nocturnal hemodialysis. Among the anti hypertensive agents currently available, angiotensin-converting enzyme (ACE) inhibitors appear to have the greatest ability to reduce left ventricular mass. Pressure load can be satisfactorily determined by using the average value of predialysis BP measurements over 1 month. In selected hemodialysis patients, interdialytic ambulatory blood pressure monitoring (ABPM) may help to determine if the patient is in fact hypertensive. In addition, ABPM provides important information about the change in BP between day and night. Regular home BP monitoring, yearly echocardiography, and treatment of traditional risk factors for cardiovascular disease are recommended. (C) 2002 by the National Kidney Foundation, Inc.
• Focus group composition: a comparison between natural and constructed groups
  作者：Julie Leask、Penelope Hawe、Simon Chapman

  DOI：10.1111/j.1753-6405.2001.tb01838.x

  日期：2001.4

  Objective: To provide insight into the effects of focus group composition.Method: In an early phase of an ongoing study of parental reception to messages about childhood immunisation, we conducted four focus groups; two with participants who had never met before (constructed groups) and two with participants who were part of a preestablished first-time mothers' group (natural groups).Results: Marked differences were noted in the group dynamics, depth of interaction and diversity between groups. Discussions with constructed groups were animated, enthusiastic, expressed more divergent views and articulated greater complexities of the topic. Discussions with natural groups were generally flatter and less enthusiastic, displaying a higher level of apparent conformity to conventional wisdom. The need to protect other participants from potentially disturbing information about vaccination was expressed across groups but acted to censor natural groups, where participants knew more of each others' sensitivities.Implications: Insight into the factors contributing to such differences may enhance understanding of the contexts in which constructed groups are more appropriate. The processes of social censorship may be of primary interest to the researcher. However, where it is paramount to elicit a range of opinions about a potentially controversial topic, we suggest that natural groups in the delicate stage of norming be avoided. The peculiarities of each individual research circumstance are best explored in pilot studies.
• Chemistry of Aegiceras majus Gaertn. IIb. Isolation of 28-Norolean-12,17-dien-3β-ol
  作者：K. Venkateswara Rao、P. K. Bose

  DOI：10.1021/jo01051a525

  日期：1962.4
• 60. Triterpenoids. Part I. Morolic acid, a new triterpenoid sapogenin
  作者：D. H. R. Barton、C. J. W. Brooks

  DOI：10.1039/jr9510000257

  日期：——
• Winterstein; Stein, Justus Liebigs Annalen der Chemie, 1933, vol. 502, p. 223,234
  作者：Winterstein、Stein

  DOI：——

  日期：——