(4-methyl-pyridin-2-yl)-quinolin-2-yl-amine | 449780-94-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (4-methyl-pyridin-2-yl)-quinolin-2-yl-amine
• 英文别名: N-(4-methylpyridin-2-yl)quinolin-2-amine；N-(4-Methyl-2-pyridinyl)-2-quinolinamine
• CAS: 449780-94-3
• 化学式: C₁₅H₁₃N₃
• 分子量: 235.288
• InChiKey: AULLPZPGEQAVPO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  37.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂ 、 (4-methyl-pyridin-2-yl)-quinolin-2-yl-amine 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  用于硝基芳烃加氢的高效无磷半夹心钌(II)催化剂

  摘要：

  我们在此介绍了两种钌(II)半夹心配合物（ 1·PF 6和2·PF 6 ）的合成和表征，其特征是无膦配体 N-(吡啶-2-基)喹啉-2-胺 ( L- 1 )和N-(4-甲基吡啶-2-基)喹啉-2-胺( L-1 )。两种配合物的分子结构均通过单晶X射线衍射测定。这些配合物作为优异的无膦催化系统，用于在温和条件下在乙醇中使用硼氢化钠从相应的硝基芳烃合成芳基胺。[Ru-H] 的中间体已通过光谱研究确定。在存在 -COOH 和 -NHCOMe 官能团的情况下，还原显示出良好的化学选择性。

  DOI：

  10.1016/j.molstruc.2023.136302
• 作为产物：
  描述：

  喹啉 在 对甲苯磺酰氯 、 间氯过氧苯甲酸 作用下， 以 二氯甲烷 、 氯仿 、 水 为溶剂， 反应 2.5h， 生成 (4-methyl-pyridin-2-yl)-quinolin-2-yl-amine
  参考文献：
  名称：

  喹啉衍生物作为潜在的抗前列腺癌药物和Pim-1激酶抑制剂的合成和生物学评估

  摘要：

  在这项工作中，设计并合成了一系列喹啉衍生物作为抗肿瘤剂。大多数喹啉类药物对人前列腺癌PC-3细胞系显示出有效的抗增殖活性。其中9d，9f和9g是最有效的化合物，其GI 50值分别为2.60、2.81和1.29μM。结构-活性关系分析表明，仲胺连接的喹啉和吡啶环在抗增殖作用中起重要作用。机理研究表明9g是潜在的Pim-1激酶抑制剂，具有细胞周期阻滞和凋亡诱导能力。考虑到Pim-1在前列腺癌中活性的提高，这类化合物具有开发成为抗前列腺癌药物的潜力。

  DOI：

  10.1016/j.bmc.2016.03.016

文献信息

• [EN] BICYCLIC COMPOUNDS USEFUL FOR TREATING DISEASES CAUSED BY RETROVIRUSES<br/>[FR] COMPOSÉS BICYCLIQUES UTILES POUR LE TRAITEMENT DE MALADIES CAUSÉES PAR DES RÉTROVIRUS
  申请人：SPLICOS

  公开号：WO2015001518A1

  公开（公告）日：2015-01-08

  Described herein are methods for preventing or treating a retroviral infection and/or for preventing, inhibiting or treating a disease caused by the retroviral infection. In certain aspects, the methods described herein include contacting a cell in need thereof with compound (I), wherein (II) means a pyridazine, a pyrimidine or a pyrazine group, R independently represent a hydrogen atom, a halogen atom or a group chosen among a –CN group, a hydroxyl group, a –COOR1 group, a (C1 -C3)fluoroalkyl group, a (C1 -C3)fluoroalkoxy group, a –NO2 group, a –NR1R2 group, a (C1-C4)alkoxy group, a phenoxy group and a (C1-C3)alkyl group, said alkyl being optionally mono-substituted by a hydroxyl group, n is 1, 2 or 3, n' is 1 or 2, R' is a hydrogen atom, a halogen atom or a group chosen among a (C1-C3)alkyl group,, a hydroxyl group, a –COOR1 group, a –NO2 group, a –NR1R2 group, a morpholinyl or a morpholino group, a N-methylpiperazinyl group, a (C1-C3)fluoroalkyl group, a (C1-C4)alkoxy group and a –CN group, Z is N or C, Y is N or C, X is N or C, W is N or C, T is N or C, U is N or C, to prevent or treat the retroviral infection and/or for preventing, inhibiting or treating a disease caused by the retroviral infection, wherein the retroviral infection is not HIV and the disease caused by the retroviral infection is not AIDS.

  本文描述了一种预防或治疗逆转录病毒感染和/或预防、抑制或治疗由逆转录病毒感染引起的疾病的方法。在某些方面，所述方法包括将化合物(I)与需要其治疗的细胞接触，其中(II)表示吡啶嗪、嘧啶或吡嗪基团，R独立地表示氢原子、卤素原子或在-CN基团、羟基基团、-COOR1基团、(C1-C3)氟代烷基团、(C1-C3)氟代烷氧基团、-NO2基团、-NR1R2基团、(C1-C4)烷氧基团、苯氧基团和(C1-C3)烷基团中选择的一种基团，所述烷基可以选择性地被羟基基团单取代，n为1、2或3，n'为1或2，R'为氢原子、卤素原子或在(C1-C3)烷基团、羟基基团、-COOR1基团、- 基团、-NR1R2基团、吗啉基或吗啉基团、N-甲基哌嗪基团、(C1-C3)氟代烷基团、(C1-C4)烷氧基团和-CN基团中选择的一种基团，Z为N或C，Y为N或C，X为N或C，W为N或C，T为N或C，U为N或C，以预防或治疗逆转录病毒感染和/或预防、抑制或治疗由逆转录病毒感染引起的疾病，其中逆转录病毒感染不是HIV，由逆转录病毒感染引起的疾病不是艾滋病。
• Polyaminopyridines and method for producing same
  申请人：Kanbara Takaki

  公开号：US20060293503A1

  公开（公告）日：2006-12-28

  The present invention provides novel polyaminopyridines which are excellent in solubility in various solvents, and are preferably used in a polymer-type organic electroluminescent material, and a process for preparing the same. More particularly, the present invention provides polyaminopyridines having a repetition structural unit represented by the following general formula (1); and having a number average molecular weight in a range of 500 to 1000000.

  本发明提供了新型的聚氨基吡啶，其在各种溶剂中具有优异的溶解性，并且最好用于聚合物型有机电致发光材料，并提供了制备它们的过程。更具体地，本发明提供了具有以下一般式（1）所表示的重复结构单元的聚氨基吡啶，其具有500至1000000之间的数均分子量。
• COMPOUNDS USEFUL FOR TREATING PREMATURE AGING AND IN PARTICULAR PROGERIA
  申请人：Tazi Jamal

  公开号：US20120329796A1

  公开（公告）日：2012-12-27

  The present invention relates to compound (I) wherein: means a pyridazine, a pyrimidine or a pyrazine group, R independently represent a hydrogen atom, a halogen atom or a group chosen among a —CN group, a hydroxyl group, a —COOR 1 group, a (C 1 -C 3 )fluoroalkyl group, a (C 1 -C 3 )fluoroalkoxy group, a —NO2 group, a —NRiR2 group, a (C 1 -C 4 )alkoxy group, a phenoxy group and a (C 1 -C 3 )alkyl group, said alkyl being optionally mono-substituted by a hydroxyl group, n is 1, 2 or 3, n′ is 1 or 2, R′ is a hydrogen atom, a halogen atom or a group chosen among a (Ci-C3)alkyl group, a hydroxyl group, a —COOR 1 group, a —NO2 group, a —NR 1 R 2 group, a morpholinyl or a morpholino group, a N-methylpiperazinyl group, a (Ci-C3)fluoroalkyl group, a (C 1 -C 4 )alkoxy group and a —CN group, Z is N or C, Y is N or C, X is N or C, W is N or C, T is N or C, U is N or C, for use as an agent for preventing, inhibiting or treating pathological or nonpathological conditions linked with premature aging. Some of said compounds are new and also form part of the invention.

  本发明涉及化合物(I)，其中：表示吡啶嗪、嘧啶或吡嗪基团，R独立地表示氢原子、卤素原子或在-CN基团、羟基基团、-COOR1基团、(C1-C3)氟烷基团、(C1-C3)氟烷氧基团、-NO2基团、-NRiR2基团、(C1-C4)烷氧基团、苯氧基团和(C1-C3)烷基团中选择的一种基团，所述烷基可以选择性地被一个羟基基团单取代，n为1、2或3，n'为1或2，R'为氢原子、卤素原子或在(Ci-C3)烷基团、羟基基团、-COOR1基团、- 基团、-NR1R2基团、吗啉基或吗啉基团、N-甲基哌嗪基团、(Ci-C3)氟烷基团、(C1-C4)烷氧基团和-CN基团中选择的一种基团，Z为N或C，Y为N或C，X为N或C，W为N或C，T为N或C，U为N或C，用作预防、抑制或治疗与早衰有关的病理或非病理状态的药剂。其中一些化合物是新的，也是本发明的一部分。
• POLYAMINOPYRIDINES AND METHOD FOR PRODUCING SAME
  申请人：SUMITOMO SEIKA CHEMICALS CO., LTD.

  公开号：EP1669390A1

  公开（公告）日：2006-06-14

  The present invention provides novel polyaminopyridines which are excellent in solubility in various solvents, and are preferably used in a polymer-type organic electroluminescent material, and a process for preparing the same. More particularly, the present invention provides polyaminopyridines having a repetition structural unit represented by the following general formula (1); and having a number average molecular weight in a range of 500 to 1000000.

  本发明提供了在各种溶剂中溶解性极佳的新型聚氨基吡啶，优选用于聚合物型有机电致发光材料，并提供了制备该材料的工艺。更具体地说，本发明提供了具有以下通式（1）所代表的重复结构单元的聚氨基吡啶； 且平均分子量在 500 至 1000000 之间。
• Compounds useful to treat premature aging and in particular progeria
  申请人：Splicos Sas

  公开号：EP2261214A1

  公开（公告）日：2010-12-15

  The present invention relates to a compound of formula (I): wherein: means an aromatic ring wherein V is C or N and when V is N, V is in ortho, meta or para of Z, i.e. forms respectively a pyridazine, a pyrimidine or a pyrazine group, R independently represents a hydrogen atom, a halogen atom or a group chosen among a (C1-C3)alkyl group, a -CN group, a -COOH group, a (C1-C3)fluoroalkyl group, a (C1-C3)fluoroalkoxy group, a -NO2 group, a -NR1R2 group and a (C1-C3)alkoxy group, R1 and R2 are independently a hydrogen atom or a (C1-C3)alkyl group, n is 1 or 2, R' is a hydrogen atom or a group chosen among a (C1-C3)alkyl group, a halogen atom, a hydroxy group, a -COOH group and a -CN group, R" is a hydrogen atom or a (C1-C4)alkyl group, Z is N or C, Y is N or C, X is N or C, W is N or C, and wherein at most two of the groups Z, Y, X and W are N, or anyone of its pharmaceutically acceptable salt, for use as an agent for preventing, inhibiting or treating pathological or nonpathological conditions linked with premature aging.

  本发明涉及一种式 (I) 的化合物： 其中 指一个芳香环，其中 V 是 C 或 N，当 V 是 N 时，V 位于 Z 的正位、偏位或对位，即分别形成哒嗪、嘧啶或吡嗪基团、 R 独立地代表氢原子、卤素原子或选自 (C1-C3) 烷基、-CN 基团、-COOH 基团、(C1-C3) 氟烷基、(C1-C3) 氟烷氧基、-NO2 基团、-NR1R2 基团和 (C1-C3) 烷氧基的基团、 R1 和 R2 独立地为氢原子或 (C1-C3) 烷基、 n 为 1 或 2、 R'是氢原子或选自(C1-C3)烷基、卤素原子、羟基、-COOH 基和-CN 基的基团、 R "是氢原子或 (C1-C4) 烷基、 Z 是 N 或 C、 Y 是 N 或 C X 是 N 或 C W 是 N 或 C、 其中 Z、Y、X 和 W 至多有两个基团是 N、 或其任何一种药学上可接受的盐、 用于预防、抑制或治疗与过早衰老有关的病理或非病理状况。