1-[ethyl-(6-hydrazinylpyridazin-3-yl)amino]propan-2-ol;hydron;dichloride

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-[ethyl-(6-hydrazinylpyridazin-3-yl)amino]propan-2-ol;hydron;dichloride
• 化学式: C9H19Cl2N5O
• 分子量: 284.18
• InChiKey: OQPVSMXUUBDLSL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.81
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  87.3
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1-[[6-[(2E)-2-benzylidenehydrazinyl]pyridazin-3-yl]-ethylamino]propan-2-ol 、 盐酸 以92%的产率得到
  参考文献：
  名称：

  PIFFERI G.; PARRAVICINI F.; CARPI C.; DORIGOTTI L., J. MED. CHEM. , 1975, 18, NO 7, 741-746

  摘要：

  DOI：

文献信息

• Process of making
  申请人：I.S.F. S.p.A.

  公开号：US04575552A1

  公开（公告）日：1986-03-11

  Preparation of ethyl 6-[ethyl-(2-hydroxypropyl)amino]-3-pyridazinyl} hydrazino carboxylate is disclosed from 3-chloro-6-hydrazinopyridazine in protected form, which is oxidized to yield the corresponding azo derivative, which is treated with ethyl-(2-hydroxypropyl)amine in the presence of strong bases, the corresponding amino derivative being subjected to reduction and deprotection, and finally acylated to yield ethyl 6-[ethyl-(2-hydroxypropyl)amino]-3-pyridazinyl} hydrazinocarboxylate.

  本文披露了从3-氯-6-肼基吡嗪保护形式制备乙基6-[乙基-(2-羟基丙基)氨基]-3-吡啶酰肼酸酯的方法。首先，3-氯-6-肼基吡嗪被氧化生成相应的偶氮衍生物，然后在强碱存在下与乙基-(2-羟基丙基)胺反应，得到相应的氨基衍生物，经过还原和去保护处理后，最终酰化得到乙基6-[乙基-(2-羟基丙基)氨基]-3-吡啶酰肼酸酯。
• Triphenylmethyl azo and hydrazino substituted pyridazines
  申请人：I.S.F. S.p.A.

  公开号：US04632982A1

  公开（公告）日：1986-12-30

  Preparation of ethyl 6-[ethyl-(2-hydroxypropyl)amino]-3-pyridazinyl}hydrazino carboxylate is disclosed, from 3-chloro-6-hydrazinopyridazine in protected form, which is oxidized to yield the corresponding azo derivative, which is treated with ethyl-(2-hydroxypropyl)amine in the presence of strong bases, the corresponding amino derivative being subjected to reduction and deprotection, and finally acylated to yield ethyl6-[ethyl-(2-hydroxypropyl)amino]-3-pyridazinyl}hydrazinocarboxylate.

  本文披露了制备乙酰基6-[乙基-(2-羟基丙基)氨基]-3-吡啶酰肼酸乙酯的方法。该方法从以保护形式存在的3-氯-6-肼基吡啶酮出发，氧化制得相应的偶氮衍生物，再在强碱存在下与乙基-(2-羟基丙基)胺反应，得到相应的氨基衍生物，经过还原和脱保护处理后，最终酰化得到乙酰基6-[乙基-(2-羟基丙基)氨基]-3-吡啶酰肼酸乙酯。
• Preparation of a pharmaceutically active pyridazine derivative
  申请人：I.S.F. Socièta per Azioni

  公开号：EP0124058A1

  公开（公告）日：1984-11-07

  Preparation of ethyl6-[ethyl-(2-hydroxypropyl)amino]-3-pyridazinyl}hydrazino carboxylate is disclosed, from 3-chloro-6-hydrazinopyridazine in protected form, which is oxidized to yield the corresponding azo derivative, which is treated with ethyl-(2-hydroxypropyl)amine in the presence of strong bases, the corresponding amino derivative being subjected to reduction and deprotection, and finally acylated to yield ethyl6-[ethyl-(2-hydroxypropyl)amino]-3-pyridazinyl}hydrazinocarboxylate.

  本发明公开了6-[乙基-(2-羟基丙基)氨基]-3-哒嗪基}肼基羧酸乙酯的制备方法，其原料为受保护形式的 3-氯-6-肼基哒嗪，经氧化后得到相应的偶氮衍生物、在强碱存在下用乙基-(2-羟基丙基)胺处理，相应的氨基衍生物被还原和脱保护，最后酰化得到6-[乙基-(2-羟基丙基)氨基]-3-哒嗪基}肼基羧酸乙酯。
• US4086343A
  申请人：——

  公开号：US4086343A

  公开（公告）日：1978-04-25
• US4575552A
  申请人：——

  公开号：US4575552A

  公开（公告）日：1986-03-11