4-甲基氨基-N-甲基-3-喹啉磺酰胺 | 157494-20-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 4-甲基氨基-N-甲基-3-喹啉磺酰胺
• 英文名称: 4-methylamino-N-methyl-3-quinolinesulfonamide
• 英文别名: N-methyl-4-(methylamino)quinoline-3-sulfonamide
• CAS: 157494-20-7
• 化学式: C₁₁H₁₃N₃O₂S
• 分子量: 251.309
• InChiKey: KFYPTZPQEQMNAW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  79.5
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-甲基氨基-N-甲基-3-喹啉磺酰胺 在 sodium hydroxide 作用下， 以 水 为溶剂， 反应 1.5h， 生成 1,4-dihydro-1,N-dimethyl-4-oxo-3-quinolinesulfonamide
  参考文献：
  名称：

  The Preparation of 1-Methyl- (and Ethyl)-1,4-dihydro-4-oxo- and 4-thioxo-3-quinolinesulfonamides from 4-Amino-3-quinolinesulfonamides

  摘要：

  DOI：

  10.3987/com-99-8607
• 作为产物：
  描述：

  1,4-dithiino[2,3-c:5,6-c']diquinoline 在 氯 、 溶剂黄146 作用下， 以 氯仿 、 水 、 甲苯 为溶剂， 反应 0.75h， 生成 4-甲基氨基-N-甲基-3-喹啉磺酰胺
  参考文献：
  名称：

  Synthesis and Amination of 4-Chloro-3-quinolinesulfonyl Chloride

  摘要：

  Chlorinolysis of 4-chloro-3-benzylthioquinoline (2) or thioquinanthrene (1) using chlorine gas in the presence of water gave 4-chloro-3-quinolinesulfonyl chloride (3). Amination of (3) performed in ether led to 4-chloro-3-quinolinesulfonamides (4). Reactions of compound (3) with an excess of primary or secondary amine in two phase (water/toluene or benzene) system gave 4-(substituted amino)-3-quinolinesulfonamides (5) with two identical amine rests. While 4-chloro-3-quinolinesulfonamides (4) were aminated with an excess of amine into aminosulfonamides (5) with two identical or two various amine rests.

  DOI：

  10.3987/com-94-6683

文献信息

• Hydrolysis of 4-Amino-3-qunolinesulfonamides
  作者：Leszek Skrzypek

  DOI：10.3987/com-98-8164

  日期：——

  Acid hydrolysis of 4-amino-3-quinolinesulfonamides (3) gives 1,4-dihydro-4-oxo-3-quinolinesulfonamides (4), 4-aminoquinolines (5) or a mixture of these compounds.
• Malankiewicz Andrzej, Skrzypek Leszek, Heterocycles, 38 (1994) N 6, S 1317-1331
  作者：Malankiewicz Andrzej, Skrzypek Leszek

  DOI：——

  日期：——
• Synthesis and Amination of 4-Chloro-3-quinolinesulfonyl Chloride
  作者：Andrzej Maslankiewicz、Leszek Skrzypek

  DOI：10.3987/com-94-6683

  日期：——

  Chlorinolysis of 4-chloro-3-benzylthioquinoline (2) or thioquinanthrene (1) using chlorine gas in the presence of water gave 4-chloro-3-quinolinesulfonyl chloride (3). Amination of (3) performed in ether led to 4-chloro-3-quinolinesulfonamides (4). Reactions of compound (3) with an excess of primary or secondary amine in two phase (water/toluene or benzene) system gave 4-(substituted amino)-3-quinolinesulfonamides (5) with two identical amine rests. While 4-chloro-3-quinolinesulfonamides (4) were aminated with an excess of amine into aminosulfonamides (5) with two identical or two various amine rests.
• The Preparation of 1-Methyl- (and Ethyl)-1,4-dihydro-4-oxo- and 4-thioxo-3-quinolinesulfonamides from 4-Amino-3-quinolinesulfonamides
  作者：Leszek Skrzypek

  DOI：10.3987/com-99-8607

  日期：——