8-溴乙酰基喹啉 | 860113-88-8

• 物质功能分类: 医药中间体 - 杂环化合物 - 喹啉类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 8-溴乙酰基喹啉
• 英文名称: 2-Bromo-1-quinolin-8-yl-ethanone
• 英文别名: 2-Bromo-1-(quinolin-8-yl)ethan-1-one；2-bromo-1-quinolin-8-ylethanone
• CAS: 860113-88-8
• 化学式: C₁₁H₈BrNO
• 分子量: 250.095
• InChiKey: NCVOFLIRNPFPSE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 危险品标志：
  Xn
• 安全说明：
  S26,S36
• 危险类别码：
  R20/21/22,R36/37/38

反应信息

• 作为反应物：
  描述：

  8-溴乙酰基喹啉 在 ammonium acetate 、 吡啶盐酸盐 作用下， 反应 8.0h， 生成 2-[1-[2,6-Di(propan-2-yl)phenyl]-4-quinolin-8-ylimidazol-2-yl]phenanthridin-10-ol
  参考文献：
  名称：

  ORGANOMETALLIC COMPOUND, LIGHT-EMITTING DEVICE INCLUDING THE ORGANOMETALLIC COMPOUND, AND ELECTRONIC APPARATUS AND ELECTRONIC DEVICE INCLUDING THE LIGHT-EMITTING DEVICE

  摘要：

  The disclosure provides an organometallic compound represented by Formula 1, a light-emitting device including the organometallic compound, and an electronic apparatus and an electronic device including the light-emitting device.

  公开号：

  US20240040926A1
• 作为产物：
  描述：

  8-乙酰基喹啉 在 氢溴酸 、 氧气 、 2-methylpyridinium nitrate 作用下， 以 水 为溶剂， 以78 %的产率得到8-溴乙酰基喹啉
  参考文献：
  名称：

  ORGANOMETALLIC COMPOUND, LIGHT-EMITTING DEVICE INCLUDING THE ORGANOMETALLIC COMPOUND, AND ELECTRONIC APPARATUS AND ELECTRONIC DEVICE INCLUDING THE LIGHT-EMITTING DEVICE

  摘要：

  The disclosure provides an organometallic compound represented by Formula 1, a light-emitting device including the organometallic compound, and an electronic apparatus and an electronic device including the light-emitting device.

  公开号：

  US20240040926A1

文献信息

• [EN] AMIDES AS PIM INHIBITORS<br/>[FR] AMIDES CONVENANT COMME INHIBITEURS DES PIM
  申请人：AMGEN INC

  公开号：WO2013130660A1

  公开（公告）日：2013-09-06

  The invention relates to amide-containing compounds of formula (1), and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.

  本发明涉及式(1)的含酰胺化合物及其盐。在一些实施例中，本发明涉及Pim-1和/或Pim-2和/或Pim-3蛋白激酶活性或酶功能的抑制剂或调节剂。在更进一步的实施例中，本发明涉及包含本文披露的化合物的药物组合物，及其用于预防治疗Pim激酶相关状况和疾病，尤其是癌症的应用。
• Thiazole as a carbonyl bioisostere. A novel class of highly potent and selective 5-HT3 receptor antagonists
  作者：Terry Rosen、Arthur A. Nagel、James P. Rizzi、Jeffrey L. Ives、June B. Daffeh、Alan H. Ganong、Karen Guarino、James Heym、Stafford McLean

  DOI：10.1021/jm00172a006

  日期：1990.10

  A novel structural class of highly potent and selective 5-HT3 receptor antagonists is described. The compounds in this new series contain a thiazole moiety linking an aromatic group and a nitrogen-containing basic region; the thiazole group appears to be acting as a carbonyl bioisostere in this system. An optimized member of this series, 4-(2-methoxyphenyl)-2-[[4(5)-methyl-5(4)-imidazolyl]methyl]thiazole

  描述了高效和选择性的5-HT 3受体拮抗剂的新型结构类别。这个新系列的化合物包含连接芳族基团和含氮碱性区域的噻唑部分；噻唑基似乎在该系统中充当羰基生物等排体。该系列的优化成员4-（2-甲氧基苯基）-2-[[[4（5）-甲基-5（4）-咪唑基]甲基]噻唑（5）在Bezold-Jarisch反射范例中表现出口服活性与标准药物恩丹西酮（1）和ICS-205-930（2）相当或更好。根据5-HT3受体结合的计算机药效团模型，合理化了一些构效关系。
• AMIDES AS PIM INHIBITORS
  申请人：AMGEN INC.

  公开号：US20150329538A1

  公开（公告）日：2015-11-19

  The invention relates to amide-containing compounds of formula (1), and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.

  本发明涉及公式（1）的含酰胺化合物及其盐。在某些实施例中，本发明涉及Pim-1和/或Pim-2和/或Pim-3蛋白激酶活性或酶功能的抑制剂或调节剂。在更进一步的实施例中，本发明涉及包含所述化合物的药物组合物，以及它们在预防和治疗与Pim激酶相关的疾病和病症，尤其是癌症方面的用途。
• Amides as pim inhibitors
  申请人：AMGEN INC.

  公开号：US09394297B2

  公开（公告）日：2016-07-19

  The invention relates to amide-containing compounds of formula (1), and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.

  本发明涉及式（1）的含酰胺化合物及其盐。在某些实施方式中，本发明涉及Pim-1和/或Pim-2和/或Pim-3蛋白激酶活性或酶功能的抑制剂或调节剂。在更进一步的实施方式中，本发明涉及包含所披露的化合物的制药组合物，以及它们在预防和治疗Pim激酶相关疾病和病症，尤其是癌症方面的用途。
• ROSEN, TERRY;NAGEL, ARTHUR A.;RIZZI, JAMES P.;IVES, JEFFREY L.;DAFFEH, JU+, J. MED. CHEM., 33,(1990) N0, C. 2715-2720
  作者：ROSEN, TERRY、NAGEL, ARTHUR A.、RIZZI, JAMES P.、IVES, JEFFREY L.、DAFFEH, JU+

  DOI：——

  日期：——