o-Acetoxyzimtsaeuremethylester | 75746-62-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: o-Acetoxyzimtsaeuremethylester
• 英文别名: Methyl 3-(2-acetyloxyphenyl)prop-2-enoate
• CAS: 75746-62-2
• 化学式: C₁₂H₁₂O₄
• 分子量: 220.225
• InChiKey: KFIPHURDCQOVSB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  o-Acetoxyzimtsaeuremethylester 在 二异丁基氢化铝 作用下， 以 四氢呋喃 为溶剂， 生成 [2-(3-Hydroxyprop-1-enyl)phenyl] acetate
  参考文献：
  名称：

  Synthesis and biological activity of cinnamaldehydes as angiogenesis inhibitors

  摘要：

  A series of 2-hydroxycinnamaldehyde derivatives was synthesized for examing a structure-activity relationship for inhibition of angiogenesis. The anti-angiogenic effects of 2'-substituted cinnamaldehdes and related analogs were determined in a chick embryo chorioallantoic membrane assay system. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)10008-7
• 作为产物：
  描述：

  重氮甲烷 、 2-乙酰氧基肉桂酸 以 甲醇 为溶剂， 生成 o-Acetoxyzimtsaeuremethylester
  参考文献：
  名称：

  Synthesis and biological activity of cinnamaldehydes as angiogenesis inhibitors

  摘要：

  A series of 2-hydroxycinnamaldehyde derivatives was synthesized for examing a structure-activity relationship for inhibition of angiogenesis. The anti-angiogenic effects of 2'-substituted cinnamaldehdes and related analogs were determined in a chick embryo chorioallantoic membrane assay system. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)10008-7

文献信息

• Synthesis and biological activity of cinnamaldehydes as angiogenesis inhibitors
  作者：Byoung-Mog Kwon、Seung-Ho Lee、Young-Kwon Cho、Song-Hae Bok、Seung-Ho So、Mi-Ran Youn、Soo-Ik Chang

  DOI：10.1016/s0960-894x(97)10008-7

  日期：1997.10

  A series of 2-hydroxycinnamaldehyde derivatives was synthesized for examing a structure-activity relationship for inhibition of angiogenesis. The anti-angiogenic effects of 2'-substituted cinnamaldehdes and related analogs were determined in a chick embryo chorioallantoic membrane assay system. (C) 1997 Elsevier Science Ltd.