2-methylsulfanyl-1,4-bis(4-nitrophenyl)but-2-ene-1,4-dione | 1316302-69-8

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物
• 英文名称: 2-methylsulfanyl-1,4-bis(4-nitrophenyl)but-2-ene-1,4-dione
• CAS: 1316302-69-8
• 化学式: C₁₇H₁₂N₂O₆S
• 分子量: 372.358
• InChiKey: MJIYBOWASBMBQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.82
• 重原子数：
  26.0
• 可旋转键数：
  7.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  120.42
• 氢给体数：
  0.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  2-methylsulfanyl-1,4-bis(4-nitrophenyl)but-2-ene-1,4-dione 、 苯胺 以 乙醇 为溶剂， 反应 28.0h， 以91%的产率得到(Z)-1,4-bis(4-nitrophenyl)-2-(phenylamino)but-2-ene-1,4-dione
  参考文献：
  名称：

  Substrate-controlled and highly stereoselective synthesis of 2-aminobut-2-ene-1, 4-diones

  摘要：

  2-Methylthio-substituted 1,4-enediones, obtained from readily available aryl methyl ketones, were reacted with primary or secondary amines to afford the desired 1,4-diaryl-2-aminobut-2-ene-1,4-diones in excellent yields with high Z/E-stereoselectivity. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.03.049
• 作为产物：
  描述：

  二甲基亚砜 、 对硝基苯乙酮 在 碘 、 copper(II) oxide 作用下， 生成 2-methylsulfanyl-1,4-bis(4-nitrophenyl)but-2-ene-1,4-dione
  参考文献：
  名称：

  Substrate-controlled and highly stereoselective synthesis of 2-aminobut-2-ene-1, 4-diones

  摘要：

  2-Methylthio-substituted 1,4-enediones, obtained from readily available aryl methyl ketones, were reacted with primary or secondary amines to afford the desired 1,4-diaryl-2-aminobut-2-ene-1,4-diones in excellent yields with high Z/E-stereoselectivity. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.03.049

文献信息

• A facile synthesis of indole–furan conjugates via integration of convergent and linear domino reactions
  作者：Yan Yang、Meng Gao、Liu-Ming Wu、Cong Deng、Dong-Xue Zhang、Yang Gao、Yan-Ping Zhu、An-Xin Wu

  DOI：10.1016/j.tet.2011.05.058

  日期：2011.7

  The convergent and linear domino reactions have been first integrated, for the first time, to provide an efficient synthesis of indole–furan conjugates from indoles, methyl ketones, and 1,3-dicarbonyl compounds.

  融合和线性多米诺反应首次被首次整合，以提供由吲哚，甲基酮和1,3-二羰基化合物有效合成吲哚-呋喃共轭物的方法。
• A new route to construct 1,2-dihydroquinoxaline and 1,4-benzoxazine derivatives stereoselectively and its application to novel pyrazolo[1,5-α]quinoxaline oxides
  作者：Dongxue Zhang、Yan Yang、Meng Gao、Wenming Shu、Liuming Wu、Yanping Zhu、Anxin Wu

  DOI：10.1016/j.tet.2012.12.060

  日期：2013.2

  constructed stereoselectively from easily available aryl methyl ketones via a two-step procedure in mild conditions with high yields. Moreover, the application of this reaction provided a convenient approach to novel pyrazolo[1,5-α]quinoxaline oxides.

  从容易获得的芳基甲基酮经两步操作，在温和的条件下以高收率立体选择性地构建1,2-二氢喹喔啉和1,4-苯并恶嗪骨架。此外，该反应的应用为新型吡唑并[1，5-α]喹喔啉氧化物提供了一种方便的方法。
• Substrate-controlled and highly stereoselective synthesis of 2-aminobut-2-ene-1, 4-diones
  作者：Cong Deng、Yan Yang、Meng Gao、Yan-Ping Zhu、An-Xin Wu、Jun-Rui Ma、Guo-Dong Yin

  DOI：10.1016/j.tet.2012.03.049

  日期：2012.5

  2-Methylthio-substituted 1,4-enediones, obtained from readily available aryl methyl ketones, were reacted with primary or secondary amines to afford the desired 1,4-diaryl-2-aminobut-2-ene-1,4-diones in excellent yields with high Z/E-stereoselectivity. (C) 2012 Elsevier Ltd. All rights reserved.