<2S,3R,4R,5S>-2-Benzyloxymethyl-4-t-butyldimethylsilyloxy-3-hydroxy-8-(4-methoxybenzyl)-6,8-diaza-1-oxaspiro<4.4>nonane-7,9-dione | 129744-37-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: <2S,3R,4R,5S>-2-Benzyloxymethyl-4-t-butyldimethylsilyloxy-3-hydroxy-8-(4-methoxybenzyl)-6,8-diaza-1-oxaspiro<4.4>nonane-7,9-dione
• 英文别名: (5R,7R,8S,9S)-7-Benzyloxymethyl-9-(tert-butyl-dimethyl-silanyloxy)-8-hydroxy-3-(4-methoxy-benzyl)-6-oxa-1,3-diaza-spiro[4.4]nonane-2,4-dione；<2S,3R,4S,5R>-2-Benzyloxymethyl-4-t-butyldimethylsilyloxy-3-hydroxy-8-(4-methoxybenzyl)-6,8-diaza-1-oxaspiro<4.4>nonane-7,9-dione；(5R,7R,8R,9S)-7-Benzyloxymethyl-9-(tert-butyl-dimethyl-silanyloxy)-8-hydroxy-3-(4-methoxy-benzyl)-6-oxa-1,3-diaza-spiro[4.4]nonane-2,4-dione；(5S,7R,8S,9S)-7-Benzyloxymethyl-9-(tert-butyl-dimethyl-silanyloxy)-8-hydroxy-3-(4-methoxy-benzyl)-6-oxa-1,3-diaza-spiro[4.4]nonane-2,4-dione；<2S,3R,4R,5R>-2-Benzyloxymethyl-4-t-butyldimethylsilyloxy-3-hydroxy-8-(4-methoxybenzyl)-6,8-diaza-1-oxaspiro<4.4>nonane-7,9-dione；<2R,3R,4S,5R>-2-Benzyloxymethyl-4-t-butyldimethylsilyloxy-3-hydroxy-8-(4-methoxybenzyl)-6,8-diaza-1-oxaspiro<4.4>nonane-7,9-dione；<2R,3R,4S,5S>-4-t-Butyldimethylsilyloxy-2-benzyloxymethyl-3-hydroxy-8-(4-methoxybenzyl)-1-oxa-6,8-diazaspiro<4.4>nonane-7,9-dione
• CAS: 129744-37-2；129829-41-0；129829-47-6；130606-88-1；130606-89-2；130606-96-1；130606-97-2；130607-42-0；130607-43-1
• 化学式: C₂₈H₃₈N₂O₇Si
• 分子量: 542.704
• InChiKey: VQZIINRJGVPMBT-PVIBPIFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.81
• 重原子数：
  38.0
• 可旋转键数：
  9.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  106.56
• 氢给体数：
  2.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  <2S,3R,4R,5S>-2-Benzyloxymethyl-4-t-butyldimethylsilyloxy-3-hydroxy-8-(4-methoxybenzyl)-6,8-diaza-1-oxaspiro<4.4>nonane-7,9-dione 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 生成 <2R,3R,4R,5S>-2-Benzyloxymethyl-3,4-dihydroxy-8-(4-methoxybenzyl)-1-oxa-6,8-diazaspiro<4.4>nonane-7,9-dione
  参考文献：
  名称：

  Synthetic studies on (+)-hydantocidin (2): Aldol addition approaches toward the stereoisomers of (+)-hydantocidin

  摘要：

  The spiro-hydantoin ring at the anomeric position of D-and L-furanose was constructed by using aldol addition followed by acid promoted cyclization and the synthesis of thestereoisomers of (+)-hydantocidin, L- and D-series of spiro-furanose 2, 3, 4 and 5.

  DOI：

  10.1016/s0040-4020(01)96123-x
• 作为产物：
  描述：

  <5R,1'R,2'R,3'S>-5-(1'-t-Butyldimethylsilyloxy-2',3'-O-isopropylidenedioxy-4'-benzyloxy)butyl-5-methoxy-3-(4-methoxybenzyl)-1-N-methoxycarbonylhydantoin 在 potassium carbonate 、 对甲苯磺酸 、 乙二醇 作用下， 以 甲醇 、 1,2-二氯乙烷 为溶剂， 生成 <2S,3R,4R,5S>-2-Benzyloxymethyl-4-t-butyldimethylsilyloxy-3-hydroxy-8-(4-methoxybenzyl)-6,8-diaza-1-oxaspiro<4.4>nonane-7,9-dione
  参考文献：
  名称：

  Synthetic studies on (+)-hydantocidin (2): Aldol addition approaches toward the stereoisomers of (+)-hydantocidin

  摘要：

  The spiro-hydantoin ring at the anomeric position of D-and L-furanose was constructed by using aldol addition followed by acid promoted cyclization and the synthesis of thestereoisomers of (+)-hydantocidin, L- and D-series of spiro-furanose 2, 3, 4 and 5.

  DOI：

  10.1016/s0040-4020(01)96123-x