2'-hydroxy-6",6"-dimethyl-4",5"-dihydropyrano<2",3":4',5'>chalcone | 52601-07-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 2'-hydroxy-6",6"-dimethyl-4",5"-dihydropyrano<2",3":4',5'>chalcone
• 英文别名: 1-(7-hydroxy-2,2-dimethylchroman-6-yl)-3-phenylpropenone；(E)-1-(7-hydroxy-2,2-dimethylchroman-6-yl)-3-phenylprop-2-en-1-one；(E)-1-(7-hydroxy-2,2-dimethyl-3,4-dihydrochromen-6-yl)-3-phenylprop-2-en-1-one
• CAS: 52601-07-7
• 化学式: C₂₀H₂₀O₃
• 分子量: 308.377
• InChiKey: XDXWKSMYQWSEJE-CMDGGOBGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2'-hydroxy-6",6"-dimethyl-4",5"-dihydropyrano<2",3":4',5'>chalcone 在 盐酸 、 sodium hydroxide 、 三氟化硼乙醚 、 双氧水 、 potassium carbonate 、 溶剂黄146 、 potassium iodide 作用下， 以 甲醇 、 丙酮 为溶剂， 反应 17.75h， 生成 3-Hydroxy-2-phenyl-8,8-dimethyl-2,3,6,7-tetrahydro-4H,8H-benzo<1,2-b; 5,4-b'>dipyran-4-one
  参考文献：
  名称：

  Suresh, R. V.; Iyer, C. S. Rukmani; Iyer, P. R., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1985, vol. 24, p. 254 - 259

  摘要：

  DOI：
• 作为产物：
  描述：

  7-acetoxy-2,2-dimethyl chroman 在 氢氧化钾 、 三氯化铝 作用下， 以 二硫化碳 、 乙醇 为溶剂， 反应 62.0h， 生成 2'-hydroxy-6",6"-dimethyl-4",5"-dihydropyrano<2",3":4',5'>chalcone
  参考文献：
  名称：

  Kumar; Rajendra Prasad, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1999, vol. 38, # 5, p. 583 - 589

  摘要：

  DOI：

文献信息

• 13C nuclear magnetic resonance studies on pyrano- and dihydropyrano-1,3- diphenylprop-2-enones
  作者：V. S. Parmar、S. K. Sharma、A. Vardhan、R. K. Sharma、S. Gupta、S. Malhotra、P. M. Boll

  DOI：10.1002/mrc.1260300619

  日期：1992.6

  The 13C NMR spectra of 19 differently substituted pyrano- and dihydropyrano-1,3-diphenylprop-2-enones were recorded and the results are discussed. The data will be useful in the identification of new and natural chalcones.

  记录了 19 种不同取代的吡喃-和二氢吡喃-1,3-二苯基丙-2-烯酮的 13C NMR 谱，并对结果进行了讨论。这些数据将有助于鉴定新的天然查耳酮。
• Suresh, Raghava Venkataramanna; Iyer, Chandrasekharapuram Subramon.; Iyer, Parameswaran Ramasubramonia, Heterocycles, 1986, vol. 24, # 7, p. 1925 - 1930
  作者：Suresh, Raghava Venkataramanna、Iyer, Chandrasekharapuram Subramon.、Iyer, Parameswaran Ramasubramonia

  DOI：——

  日期：——
• Microwave-assisted synthesis and antimicrobial evaluation of novel pyrazolines
  作者：Ashok Dongamanti、Mohan Gandhi Devulapally、Vikas Kumar Aamate、Srinivas Gundu

  DOI：10.1007/s10593-015-1790-6

  日期：2015.10

  A series of 6-(5-aryl-4,5-dihydro-1H-pyrazol-3-yl)-2,2-dimethylchroman-7-ol and 6-(5-aryl-4,5-dihydro-1H-pyrazol-3-yl)-2,2-dimethyl-chroman-5-ol derivatives have been synthesized from the corresponding chalcones and hydrazine hydrate in the presence of sodium acetate under microwave irradiation involving the Michael addition followed by cycloaddition. All the newly synthesized 18 compounds were screened for their in vitro antimicrobial activity. Most of the compounds displayed very good to excellent antimicrobial activity in comparison to standard drugs streptomycin and nystatin.
• BF3–Et2O mediated biogenetic type synthesis of chromanochalcones from prenylated chalcones via a regioselective cyclization reaction
  作者：T. Narender、K. Papi Reddy

  DOI：10.1016/j.tetlet.2007.08.124

  日期：2007.10

  In continuation of out-program on synthetic chalcones. we have developed a simple and convenient method for the synthesis of chromanochalcones from prenylated chalcones in high yields by regioselective cyclization using BF3-Et2O. (C) 2007 Elsevier Ltd. All rights reserved.