[(2R,4aR,6S,7S,8S,8aR)-6-[(2R,3S,4S,5R,6S)-5-[tert-butyl(dimethyl)silyl]oxy-3-methoxy-2-methyl-6-tri(propan-2-yl)silyloxyoxan-4-yl]oxy-8-[(4-methoxyphenyl)methoxy]-2-phenyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-7-yl]oxy-tert-butyl-dimethylsilane | 256413-36-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [(2R,4aR,6S,7S,8S,8aR)-6-[(2R,3S,4S,5R,6S)-5-[tert-butyl(dimethyl)silyl]oxy-3-methoxy-2-methyl-6-tri(propan-2-yl)silyloxyoxan-4-yl]oxy-8-[(4-methoxyphenyl)methoxy]-2-phenyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-7-yl]oxy-tert-butyl-dimethylsilane
• CAS: 256413-36-2
• 化学式: C₄₉H₈₄O₁₁Si₃
• 分子量: 933.456
• InChiKey: QNGULBSAKPPDNA-ARWFLZHCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.54
• 重原子数：
  63
• 可旋转键数：
  19
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  102
• 氢给体数：
  0
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  [(2R,4aR,6S,7S,8S,8aR)-6-[(2R,3S,4S,5R,6S)-5-[tert-butyl(dimethyl)silyl]oxy-3-methoxy-2-methyl-6-tri(propan-2-yl)silyloxyoxan-4-yl]oxy-8-[(4-methoxyphenyl)methoxy]-2-phenyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-7-yl]oxy-tert-butyl-dimethylsilane 在 水 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以95%的产率得到
  参考文献：
  名称：

  Total Synthesis of Everninomicin 13,384-1—Part 3: Synthesis of the DE Fragment and Completion of the Total Synthesis

  摘要：

  DOI：

  10.1002/(sici)1521-3773(19991115)38:22<3345::aid-anie3345>3.0.co;2-9
• 作为产物：
  描述：

  phenyl 4,6-O-benzylidene-1-thio-α-D-mannopyranoside 在 2,6-二甲基吡啶 、 di-tert-butyl-4-methylpyridine 、 三氟甲磺酸酐 、 二正丁基氧化锡 、 间氯过氧苯甲酸 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 7.5h， 生成 [(2R,4aR,6S,7S,8S,8aR)-6-[(2R,3S,4S,5R,6S)-5-[tert-butyl(dimethyl)silyl]oxy-3-methoxy-2-methyl-6-tri(propan-2-yl)silyloxyoxan-4-yl]oxy-8-[(4-methoxyphenyl)methoxy]-2-phenyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-7-yl]oxy-tert-butyl-dimethylsilane
  参考文献：
  名称：

  Total Synthesis of Everninomicin 13,384-1—Part 3: Synthesis of the DE Fragment and Completion of the Total Synthesis

  摘要：

  DOI：

  10.1002/(sici)1521-3773(19991115)38:22<3345::aid-anie3345>3.0.co;2-9

文献信息

• Total Synthesis of Everninomicin 13,384-1—Part 3: Synthesis of the DE Fragment and Completion of the Total Synthesis
  作者：K. C. Nicolaou、Helen J. Mitchell、Rosa Maria Rodríguez、Konstantina C. Fylaktakidou、Hideo Suzuki、Scott R. Conley

  DOI：10.1002/1521-3765(20000901)6:17<3149::aid-chem3149>3.0.co;2-l

  日期：2000.9.1

  The stereoselective construction of the DE fragment (2) of everninomicin 13,384-1 (1) is reported. From the two possible ways of inserting the DE fragment between the A1B(A)C and FGHA2 domains of the natural product, the sequence involving the DEFGHA2 segment was found to be the most viable. This coupling was followed by attachment of a suitably protected and activated A1B(A)C fragment which led, after orthoester construction and final deprotection to the targeted everninomicin 13,384-1 (1), completing the total synthesis of this complex naturally occurring substance.