N-(9-羟基-9H-芴-2-基)乙酰胺 | 57229-41-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 中文名称: N-(9-羟基-9H-芴-2-基)乙酰胺
• 英文名称: 9-Hydroxy-2-acetylaminofluorene
• 英文别名: 2-acetylamino-9-fluorenol；N-(9-hydroxy-9H-fluoren-2-yl)acetamide；2-Acetamino-fluorenol-(9)；N-(9-hydroxy-fluoren-2-yl)-acetamide；N-(9-Hydroxy-fluoren-2-yl)-acetamid；2-Acetylamino-fluoren-9-ol
• CAS: 57229-41-1
• 化学式: C₁₅H₁₃NO₂
• 分子量: 239.274
• InChiKey: AWIRWBJUFQZCLT-UHFFFAOYSA-N

物化性质

• 沸点：
  381.93°C (rough estimate)
• 密度：
  1.1198 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

制备方法与用途

类别：有毒物品

可燃性危险特性

• 可燃；加热分解时会释放有毒氮氧化物烟雾

储运特性

• 应存放在通风良好、低温干燥的库房中

灭火剂

• 干粉、泡沫、砂土、二氧化碳或雾状水

反应信息

• 作为反应物：
  描述：

  N-(9-羟基-9H-芴-2-基)乙酰胺 在 碘 作用下， 以 三甘醇二甲醚 为溶剂， 反应 0.13h， 以75%的产率得到N-(9-氧代芴-2-基)乙酰胺
  参考文献：
  名称：

  Mukhopadhyay; Becker; Banik, Journal of Chemical Research - Part S, 2001, # 1, p. 28 - 31

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氨基-9-芴酮 在 甲醇 、 sodium tetrahydroborate 、 sodium carbonate 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 生成 N-(9-羟基-9H-芴-2-基)乙酰胺
  参考文献：
  名称：

  METHODS OF MAKING OLIGOPOTENT AND UNIPOTENT PRECURSORS

  摘要：

  本公开涉及的是从扩增的CD34+细胞来源中在培养中准备定义谱系的寡能和单能祖细胞的方法和系统，用于制备相应的培养基，以及包含相应的治疗化合物和组合物，用于治疗各种疾病，包括但不限于血液学疾病、免疫性疾病、癌症和传染性疾病。

  公开号：

  US20220315895A1

文献信息

• [EN] COMPOSITIONS AND METHODS OF MAKING EXPANDED HEMATOPOIETIC STEM CELLS USING DERIVATIVES OF FLUORENE<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE PRODUCTION DE CELLULES SOUCHES HÉMATOPOÏÉTIQUES EXPANSÉES METTANT EN OEUVRE DES DÉRIVÉS DE FLUORÈNE
  申请人：TRANSFUSION HEALTH LLC

  公开号：WO2019084452A1

  公开（公告）日：2019-05-02

  This invention is directed to, inter alia, compounds, methods, systems, and compositions for the maintenance, enhancement, and expansion of hematopoietic stem cells derived from one or more sources of CD34+ cells. Sources of CD34+ cells include bone marrow, cord blood, mobilized peripheral blood, and non-mobilized peripheral blood. Also provided herein are compounds of Formula I which are useful in maintaining, enhancing, and expanding of hematopoietic stem cells.

  这项发明涉及一些内容，包括用于维持、增强和扩展来源于一个或多个CD34+细胞源的造血干细胞的化合物、方法、系统和组合物。CD34+细胞的来源包括骨髓、脐带血、动员的外周血和非动员的外周血。本文还提供了一些Formula I的化合物，这些化合物在维持、增强和扩展造血干细胞方面是有用的。
• METHODS OF MAKING OLIGOPOTENT AND UNIPOTENT PRECURSORS
  申请人：Transfusion Health, LLC

  公开号：US20220315895A1

  公开（公告）日：2022-10-06

  This disclosure is directed to, inter alia, methods and systems for preparing oligopotent and unipotent progenitor cells of defined lineages in culture from an expanded source of CD34+ cells, media for making the same, and therapeutic compounds and compositions comprising the same for treatment a variety of diseases included, but not limited to, hematologic disorders, immune diseases, cancers, and infectious diseases.

  本公开涉及的是从扩增的CD34+细胞来源中在培养中准备定义谱系的寡能和单能祖细胞的方法和系统，用于制备相应的培养基，以及包含相应的治疗化合物和组合物，用于治疗各种疾病，包括但不限于血液学疾病、免疫性疾病、癌症和传染性疾病。
• Oxidative transformation of 2-acetylaminofluorene by a chemical model for cytochrome P450: A water-insoluble porphyrin and tert-butyl hydroperoxide
  作者：Keiko Inami、Masataka Mochizuki

  DOI：10.1016/j.bmc.2008.03.022

  日期：2008.7

  Oxidation of 2-acetylaminofluorene (AAF), a carcinogen, by a chemical model for cytochrome P450 was investigated to identify an active mutagen and elucidate the oxidation pathway. The oxidation system consisted of a water-insoluble tetrakis(pentafluorophenyl) porphyrinatoiron(III) chloride and tert-butyl hydroperoxide. The mutagen derived from AAF by the chemical model was 2-nitro-9-fluorenone ( NO(2)F = O), which was mutagenic in Salmonella typhimurium TA1538. AAF was oxidized initially at position 9 of the fluorene carbon by the chemical model forming 2-acetylamino-9-fluorenol (AAF-OH), and then oxidized further to 2-acetylamino-9-fluorenone ( AAF = O) as a major product. Initial oxidation of the nitrogen formed 2-nitrofluorene ( NO(2)F), and further oxidation yielded 2-nitro-9-fluorenol (NO(2)F = OH) as a minor product. These products, AAF-OH, AAF = O, NO(2)F, and NO(2)F = OH, and their presumable common intermediate, N-hydroxy-2-acetylaminofluorene, were oxidized by the chemical model, and the formation of NO(2)F = O was determined. These results showed that NO(2)F = O was the mutagen derived from AAF in the presence of the chemical model and was formed via oxidation of N-OH-AAF, NO(2)F, and NO(2)F-OH. These results may lead to a new metabolic pathway of AAF. (c) 2008 Elsevier Ltd. All rights reserved.
• COMPOSITIONS AND METHODS OF MAKING EXPANDED HEMATOPOIETIC STEM CELLS USING DERIVATIVES OF FLUORENE
  申请人：Transfusion Health, LLC

  公开号：US20200255371A1

  公开（公告）日：2020-08-13

  This invention is directed to, inter alia, compounds, methods, systems, and compositions for the maintenance, enhancement, and expansion of hematopoietic stem cells derived from one or more sources of CD34+ cells. Sources of CD34+ cells include bone marrow, cord blood, mobilized peripheral blood, and non-mobilized peripheral blood. Also provided herein are compounds of Formula I which are useful in maintaining, enhancing, and expanding of hematopoietic stem cells.
• [EN] METHODS OF MAKING OLIGOPOTENT AND UNIPOTENT PRECURSORS<br/>[FR] PROCÉDÉS DE FABRICATION DE PRÉCURSEURS OLIGOPOTENTS ET UNIPOTENTS
  申请人：TRANSFUSION HEALTH LLC

  公开号：WO2020223517A1

  公开（公告）日：2020-11-05

  This disclosure is directed to, inter alia, methods and systems for preparing oligopotent and unipotent progenitor cells of defined lineages in culture from an expanded source of CD34+ cells, media for making the same, and therapeutic compounds and compositions comprising the same for treatment a variety of diseases included, but not limited to, hematologic disorders, immune diseases, cancers, and infectious diseases.