5-(2-氯苯氧基)-2-甲氧基吡啶 | 1046143-58-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 5-(2-氯苯氧基)-2-甲氧基吡啶
• 英文名称: 5-(2-chlorophenoxy)-2-methoxypyridine
• 英文别名: 5-(2-Chlorophenoxy)-2-methoxypyridine
• CAS: 1046143-58-1
• 化学式: C₁₂H₁₀ClNO₂
• 分子量: 235.67
• InChiKey: QZXSCPYNQLFJIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  31.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-(2-氯苯氧基)-2-甲氧基吡啶 在 间氯过氧苯甲酸 作用下， 以 氯仿 为溶剂， 反应 12.0h， 以60%的产率得到5-(2-chlorophenoxy)-2-methoxypyridine N-oxide
  参考文献：
  名称：

  Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase

  摘要：

  Enoyl-ACP reductase (ENR), the product of the FabI gene, from Bacillus anthracis (BaENR) is responsible for catalyzing the final step of bacterial fatty acid biosynthesis. A number of novel 2-pyridone derivatives were synthesized and shown to be potent inhibitors of BaENR. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.05.004
• 作为产物：
  描述：

  5-溴-2-甲氧基吡啶 、 邻氯苯酚 在 copper(II) carbonate 、 氢氧化钾 作用下， 反应 18.0h， 以17%的产率得到5-(2-氯苯氧基)-2-甲氧基吡啶
  参考文献：
  名称：

  Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase

  摘要：

  Enoyl-ACP reductase (ENR), the product of the FabI gene, from Bacillus anthracis (BaENR) is responsible for catalyzing the final step of bacterial fatty acid biosynthesis. A number of novel 2-pyridone derivatives were synthesized and shown to be potent inhibitors of BaENR. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.05.004

文献信息

• Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase
  作者：Suresh K. Tipparaju、Sipak Joyasawal、Sara Forrester、Debbie C. Mulhearn、Scott Pegan、Michael E. Johnson、Andrew D. Mesecar、Alan P. Kozikowski

  DOI：10.1016/j.bmcl.2008.05.004

  日期：2008.6

  Enoyl-ACP reductase (ENR), the product of the FabI gene, from Bacillus anthracis (BaENR) is responsible for catalyzing the final step of bacterial fatty acid biosynthesis. A number of novel 2-pyridone derivatives were synthesized and shown to be potent inhibitors of BaENR. (C) 2008 Elsevier Ltd. All rights reserved.