2-[(2R,3R,4R,5S,6R)-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-5-hydroxy-2,4-bis(phenylmethoxy)oxan-3-yl]isoindole-1,3-dione | 207917-19-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-[(2R,3R,4R,5S,6R)-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-5-hydroxy-2,4-bis(phenylmethoxy)oxan-3-yl]isoindole-1,3-dione
• CAS: 207917-19-9
• 化学式: C₃₄H₄₁NO₇Si
• 分子量: 603.788
• InChiKey: ZETVPYSSQHYDJC-XSETXXIFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.56
• 重原子数：
  43
• 可旋转键数：
  11
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  94.5
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2-[(2R,3R,4R,5S,6R)-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-5-hydroxy-2,4-bis(phenylmethoxy)oxan-3-yl]isoindole-1,3-dione 在 4 Angstroem MS 、 三氟化硼乙醚 、 四丁基溴化铵 、 对甲苯磺酸 、 一水合肼 、 copper(ll) bromide 作用下， 以 丙醇 、 二氯甲烷 、 乙腈 为溶剂， 反应 84.0h， 生成
  参考文献：
  名称：

  Synthesis of lipooligosaccharides related to nodulation factors ofRhizobium sp. NGR234

  摘要：

  Trisaccharide analogs of natural nodulation factors from Rhizobium sp. NGR234, namely, 2-acetamido-2-deoxy-4-O-(2-deoxy-2-hexadecanamido-beta-D-glucopyranosyl)-6-O- (2-O-methyl-alpha-L-fucopyranosyl)-D-glucopyranose and its derivatives containing a 4-O-acetyl or a 3-O-sulfo group at the L-fucose residue, were synthesized. The oligosaccharides synthesized were shown to possess biological activity.

  DOI：

  10.1007/bf02495661
• 作为产物：
  描述：

  叔丁基二甲基氯硅烷 、 benzyl 3-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranoside 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.5h， 以86%的产率得到2-[(2R,3R,4R,5S,6R)-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-5-hydroxy-2,4-bis(phenylmethoxy)oxan-3-yl]isoindole-1,3-dione
  参考文献：
  名称：

  Synthesis of lipooligosaccharides related to nodulation factors ofRhizobium sp. NGR234

  摘要：

  Trisaccharide analogs of natural nodulation factors from Rhizobium sp. NGR234, namely, 2-acetamido-2-deoxy-4-O-(2-deoxy-2-hexadecanamido-beta-D-glucopyranosyl)-6-O- (2-O-methyl-alpha-L-fucopyranosyl)-D-glucopyranose and its derivatives containing a 4-O-acetyl or a 3-O-sulfo group at the L-fucose residue, were synthesized. The oligosaccharides synthesized were shown to possess biological activity.

  DOI：

  10.1007/bf02495661

文献信息

• Synthesis of lipooligosaccharides related to nodulation factors ofRhizobium sp. NGR234
  作者：A. I. Zinin、V. I. Torgov、V. N. Shibaev、A. S. Shashkov、W. J. Broughton

  DOI：10.1007/bf02495661

  日期：1998.3

  Trisaccharide analogs of natural nodulation factors from Rhizobium sp. NGR234, namely, 2-acetamido-2-deoxy-4-O-(2-deoxy-2-hexadecanamido-beta-D-glucopyranosyl)-6-O- (2-O-methyl-alpha-L-fucopyranosyl)-D-glucopyranose and its derivatives containing a 4-O-acetyl or a 3-O-sulfo group at the L-fucose residue, were synthesized. The oligosaccharides synthesized were shown to possess biological activity.