2-(acridine-9-carboxamide)acetic acid | 908068-28-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-(acridine-9-carboxamide)acetic acid
• 英文别名: 2-(Acridine-9-carbonylamino)acetic acid
• CAS: 908068-28-0
• 化学式: C₁₆H₁₂N₂O₃
• 分子量: 280.283
• InChiKey: QUCVVBRYKAOIHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  79.3
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(acridine-9-carboxamide)acetic acid 、 (2S,3R)-2-氨基-1,3-丁二醇 在 1-羟基苯并三唑 、 N,N'-二异丙基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以97%的产率得到N-((2S,3R)-1,3-dihydroxybutan-2-ylcarbamoylmethyl)acridine-9-carboxamide
  参考文献：
  名称：

  Solid-phase synthesis of oligomers carrying several chromophore units linked by phosphodiester backbones

  摘要：

  A method for the preparation of oligomers by linking chromophore units is described. Specifically, the synthesis of chromophore units having a protected-hydroxyl group and a phosphoramidite function is described, along with a method to link several units using solid-phase phosphite-triester protocols. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.02.074
• 作为产物：
  描述：

  9-吖啶羧酸 在 草酰氯 、 三乙胺 、 三氟乙酸 作用下， 以 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 29.0h， 生成 2-(acridine-9-carboxamide)acetic acid
  参考文献：
  名称：

  Enzyme−Artificial Enzyme Interactions as a Means for Discriminating among Structurally Similar Isozymes

  摘要：

  We describe the design and function of an artificial enzyme-linked receptor (ELR) that can bind different members of the glutathione-S-transferase (GST) enzyme family. The artificial enzyme-enzyme interactions distinctly affect the catalytic activity of the natural enzymes, the biomimetic, or both, enabling the system to discriminate among structurally similar GST isozymes.

  DOI：

  10.1021/jacs.5b02496

文献信息

• Design, synthesis and antiproliferative properties of oligomers with chromophore units linked by amide backbones
  作者：Josep Farrera-Sinfreu、Anna Aviñó、Isabel Navarro、Juan Aymamí、Natàlia G. Beteta、Sònia Varón、Ricardo Pérez-Tomás、Wilmar Castillo-Avila、Ramon Eritja、Fernando Albericio、Miriam Royo

  DOI：10.1016/j.bmcl.2008.02.045

  日期：2008.4

  The preparation of oligomers made up of several chromophore units as compounds with potential fluorescent and antiproliferative properties is described. Specifically, chromophore units with protected-amino groups and one carboxylic group are described, together with methods to assemble these units using peptide chemistry. Some of these compounds have antiproliferative activity. (C) 2008 Elsevier Ltd. All rights reserved.
• Solid-phase synthesis of oligomers carrying several chromophore units linked by phosphodiester backbones
  作者：Anna Aviñó、Isabel Navarro、Josep Farrera-Sinfreu、Miriam Royo、Juan Aymamí、Antonio Delgado、Amadeu Llebaria、Fernando Albericio、Ramon Eritja

  DOI：10.1016/j.bmcl.2008.02.074

  日期：2008.4

  A method for the preparation of oligomers by linking chromophore units is described. Specifically, the synthesis of chromophore units having a protected-hydroxyl group and a phosphoramidite function is described, along with a method to link several units using solid-phase phosphite-triester protocols. (C) 2008 Elsevier Ltd. All rights reserved.
• Enzyme−Artificial Enzyme Interactions as a Means for Discriminating among Structurally Similar Isozymes
  作者：Karuthapandi Selvakumar、Leila Motiei、David Margulies

  DOI：10.1021/jacs.5b02496

  日期：2015.4.22

  We describe the design and function of an artificial enzyme-linked receptor (ELR) that can bind different members of the glutathione-S-transferase (GST) enzyme family. The artificial enzyme-enzyme interactions distinctly affect the catalytic activity of the natural enzymes, the biomimetic, or both, enabling the system to discriminate among structurally similar GST isozymes.