(2S,3R)-2-氨基-1,3-丁二醇 | 44520-54-9

• 物质功能分类: 生物 - 细胞培养 - 添加剂
• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: (2S,3R)-2-氨基-1,3-丁二醇
• 英文名称: D-allo-threoninol
• 英文别名: (2S,3R)-2-aminobutane-1,3-diol
• CAS: 44520-54-9
• 化学式: C₄H₁₁NO₂
• 分子量: 105.137
• InChiKey: MUVQIIBPDFTEKM-DMTCNVIQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  66.5
• 氢给体数：
  3
• 氢受体数：
  3

SDS

(2S,3R)-2-Amino-1,3-butanediolMSDS英文版

反应信息

• 作为反应物：
  描述：

  (2S,3R)-2-氨基-1,3-丁二醇 、 2-苯基-4-喹啉羧酸 在 1-羟基苯并三唑 、 N,N'-二异丙基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以63%的产率得到N-((2S,3R)-1,3-dihydroxybutan-2-yl)-2-phenylquinoline-4-carboxamide
  参考文献：
  名称：

  Solid-phase synthesis of oligomers carrying several chromophore units linked by phosphodiester backbones

  摘要：

  A method for the preparation of oligomers by linking chromophore units is described. Specifically, the synthesis of chromophore units having a protected-hydroxyl group and a phosphoramidite function is described, along with a method to link several units using solid-phase phosphite-triester protocols. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.02.074
• 作为产物：
  描述：

  ethyl 2-amino-3-hydroxybutanoate 在 sodium tetrahydroborate 作用下， 生成 (2S,3R)-2-氨基-1,3-丁二醇
  参考文献：
  名称：

  过胺（4-氨基-4,6-二脱氧-D-甘露糖）衍生物的合成和结构证明。

  摘要：

  DOI：

  10.1021/ja00713a039

文献信息

• [EN] DIFLUOROMETHYL-AMINOPYRIDINES AND DIFLUOROMETHYL-AMINOPYRIMIDINES<br/>[FR] DIFLUOROMÉTHYL-AMINOPYRIDINES ET DIFLUOROMÉTHYL-AMINOPYRIMIDINES
  申请人：PIQUR THERAPEUTICS AG

  公开号：WO2016075130A1

  公开（公告）日：2016-05-19

  The invention relates to novel phosphoinositide 3-kinase (PI3K),mammalian target of rapamycin (mTOR)and PI3K-related kinase(PIKKs)inhibitor compounds of formula (I), wherein X1, X2 and X3 are N or CH, with the proviso that at least two of X1, X2 and X3 are N; Y is N or CH, These compounds are useful, either alone or in combination with further therapeutic agents, for treating disorders mediated by lipid kinases.

  这项发明涉及一种新型的磷脂酰肌醇3-激酶（PI3K）、哺乳动物雷帕霉素靶蛋白（mTOR）和PI3K相关激酶（PIKKs）抑制剂化合物，其化学式为（I），其中X1、X2和X3为N或CH，但至少其中两个为N；Y为N或CH。这些化合物可用于单独使用或与其他治疗药物联合使用，用于治疗由脂质激酶介导的疾病。
• A DNA aptamer sensor for 8-oxo-7,8-dihydroguanine
  作者：Jyoti Roy、Payal Chirania、Sanniv Ganguly、Haidong Huang

  DOI：10.1016/j.bmcl.2011.12.046

  日期：2012.1

  Abasic site-containing DNA duplex is a versatile structural motif that can be used for the design of purine aptamers and sensors. In this study, several modifications were introduced to the abasic site to explore possible specific binding of free 8-oxoG, a product of DNA base excision repair. The nucleoside opposite the abasic site was replaced by pyrrolo-dC as a reporter group. Binding of 8-oxoG quenched

  含无碱基位点的DNA双链体是一种通用的结构基序，可用于嘌呤适体和传感器的设计。在这项研究中，几个修饰被引入到无碱基位点，以探索游离的8-oxoG（DNA碱基切除修复产物）可能的特异性结合。与无碱基位点相对的核苷被吡咯并-dC取代为报告基团。8-oxoG淬灭的吡咯并-dC荧光的结合高达70％。相反，腺嘌呤，鸟嘌呤，胸腺嘧啶和胞嘧啶仅显示出最小的荧光猝灭作用。最好的适体结合8-oxoG，其解离常数为5.5±0.8μM。该传感器可用于在鸟嘌呤存在下准确测量8-oxoG浓度。
• Modified siRNAs for the study of the PAZ domain
  作者：Álvaro Somoza、Montserrat Terrazas、Ramón Eritja

  DOI：10.1039/c003221b

  日期：——

  Chemical modifications aimed at stabilizing the interaction between the 3′-end of siRNAs and the PAZ domain of RISC have been tested for their effect on RNAi activity. Such modifications contribute positively to the stability of siRNAs in human serum.

  旨在稳定 siRNA 3' 端与 RISC PAZ 结构域之间相互作用的化学修饰已测试其对 RNAi 活性的影响。这些修饰对人血清中 siRNA 的稳定性有积极贡献。
• Stereochemical Study of Sphingosine by Vibrational Circular Dichroism
  作者：Atsufumi Nakahashi、Ananda Kumar C. Siddegowda、Mostafa A. S. Hammam、Siddabasave Gowda B. Gowda、Yuta Murai、Kenji Monde

  DOI：10.1021/acs.orglett.6b00477

  日期：2016.5.20

  Vibrational circular dichroism (VCD) was first applied to the stereochemical analysis of sphingosine. VCD patterns derived from the C═C stretch as well as other mid-infrared (IR) regions were practical markers to discriminate all the stereoisomers of intact sphingosine. Glutaraldehyde was found as an excellent derivatizing reagent for sphingosine which improves its solubility in VCD-friendly nonpolar

  振动圆二色性（VCD）首先用于鞘氨醇的立体化学分析。源自C═C延伸区和其他中红外（IR）区域的VCD模式是区分完整鞘氨醇的所有立体异构体的实用标记。戊二醛是鞘氨醇的极佳衍生试剂，可提高其在VCD友好型非极性溶剂（如氯仿）中的溶解度，并通过形成刚性环化结构来提高VCD强度。
• Phenylpyrrole derivative
  申请人：Daiichi Sankyo Company, Limited

  公开号：US08017610B2

  公开（公告）日：2011-09-13

  The present invention relates to a compound or a pharmacologically acceptable salt thereof having superior glucokinase activating activity, and is a compound represented by general formula (I), or pharmacologically acceptable salt thereof: [wherein, A represents, for example, an oxygen atom or sulfur atom, R1 represents, for example, a C1-C6 alkyl group, a C1-C6 alkoxy group or a C1-C6 halogenated alkyl group, A and R1 together with the carbon atom bonded thereto form a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R2 represents a phenyl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group α or a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R3 represents a hydroxy group or a C1-C6 alkoxy group, and Substituent Group α consists of, for example, a halogen atom, a C1-C6 alkyl group, a C1-C6 alkyl group substituted with 1 or 2 hydroxy group(s), a C1-C6 alkylsulfonyl group, and a group represented by the formula —V—NR5R6 (wherein, V represents a carbonyl group or a sulfonyl group, and R5 and R6 may be the same or different and respectively represent a hydrogen atom or a C1-C6 alkyl group, or R5 and R6 together with the nitrogen atom bonded thereto form a 4- to 6-membered saturated heterocycle that may be substituted with 1 or 2 group(s) independently selected from a C1-C6 alkyl group and a hydroxy group, and the 4- to 6-membered saturated heterocycle may further contain one oxygen atom or nitrogen atom)].

  本发明涉及一种具有优越的葡萄糖激酶激活活性的化合物或其药理学上可接受的盐，该化合物由通式（I）表示，或其药理学上可接受的盐：[其中，A代表例如氧原子或硫原子，R1代表例如C1-C6烷基、C1-C6烷氧基或C1-C6卤代烷基，A和R1与其结合的碳原子形成可能被1到3个独立选择的取代基α取代的杂环基，R2代表可能被1到5个独立选择的取代基α取代的苯基或可能被1到3个独立选择的取代基α取代的杂环基，R3代表羟基或C1-C6烷氧基，取代基α由例如卤素原子、C1-C6烷基、带有1或2个羟基的C1-C6烷基、C1-C6烷基磺酰基和由公式—V—NR5R6表示的基组成（其中，V代表羰基或磺酰基，R5和R6可能相同或不同，分别代表氢原子或C1-C6烷基，或者R5和R6与其结合的氮原子形成可能被1或2个独立选择的C1-C6烷基和羟基取代的4-6环饱和杂环，4-6环饱和杂环还可能含有一个氧原子或氮原子）。