2-(acridine-9-carboxamide)acetic acid methyl ester | 1029683-34-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-(acridine-9-carboxamide)acetic acid methyl ester
• 英文别名: Methyl 2-(acridine-9-carbonylamino)acetate
• CAS: 1029683-34-8
• 化学式: C₁₇H₁₄N₂O₃
• 分子量: 294.31
• InChiKey: MVPHHCCQAVENSG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  68.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(acridine-9-carboxamide)acetic acid methyl ester 在 lithium hydroxide 作用下， 以 1,4-二氧六环 、 甲醇 、 水 为溶剂， 反应 0.5h， 以55%的产率得到2-(acridine-9-carboxamide)acetic acid
  参考文献：
  名称：

  Solid-phase synthesis of oligomers carrying several chromophore units linked by phosphodiester backbones

  摘要：

  A method for the preparation of oligomers by linking chromophore units is described. Specifically, the synthesis of chromophore units having a protected-hydroxyl group and a phosphoramidite function is described, along with a method to link several units using solid-phase phosphite-triester protocols. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.02.074
• 作为产物：
  描述：

  9-吖啶羧酸 、 甘氨酸甲酯盐酸盐 在 1-羟基苯并三唑 、 N,N-二异丙基乙胺 、 N,N'-二异丙基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 以70%的产率得到2-(acridine-9-carboxamide)acetic acid methyl ester
  参考文献：
  名称：

  Solid-phase synthesis of oligomers carrying several chromophore units linked by phosphodiester backbones

  摘要：

  A method for the preparation of oligomers by linking chromophore units is described. Specifically, the synthesis of chromophore units having a protected-hydroxyl group and a phosphoramidite function is described, along with a method to link several units using solid-phase phosphite-triester protocols. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.02.074

文献信息

• Solid-phase synthesis of oligomers carrying several chromophore units linked by phosphodiester backbones
  作者：Anna Aviñó、Isabel Navarro、Josep Farrera-Sinfreu、Miriam Royo、Juan Aymamí、Antonio Delgado、Amadeu Llebaria、Fernando Albericio、Ramon Eritja

  DOI：10.1016/j.bmcl.2008.02.074

  日期：2008.4

  A method for the preparation of oligomers by linking chromophore units is described. Specifically, the synthesis of chromophore units having a protected-hydroxyl group and a phosphoramidite function is described, along with a method to link several units using solid-phase phosphite-triester protocols. (C) 2008 Elsevier Ltd. All rights reserved.