2,3-dimethoxy-4-isopropylbenzyl alcohol | 118088-55-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2,3-dimethoxy-4-isopropylbenzyl alcohol
• 英文别名: 2,3-dimethoxy-4-isopropylcarbinol；2,3-dimethoxy-4-isopropylphenylmethyl alcohol；(4-isopropyl-2,3-dimethoxyphenyl)methanol；(2,3-Dimethoxy-4-propan-2-ylphenyl)methanol
• CAS: 118088-55-4
• 化学式: C₁₂H₁₈O₃
• 分子量: 210.273
• InChiKey: LTKPGTBKYHQRFR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,3-dimethoxy-4-isopropylbenzyl alcohol 在 三溴化磷 作用下， 以95%的产率得到2,3-dimethoxy-4-isopropylphenylmethyl bromide
  参考文献：
  名称：

  The Total Snthesis of (±)-barbatusol

  摘要：

  An eight-step synthesis of the naturally occurring hypotensive diterpene barbatusol (3) featuring a Friedel-Crafts annulation is reported.

  DOI：

  10.1016/0040-4039(93)85098-h
• 作为产物：
  描述：

  聚合甲醛 、 1,2-二甲氧基-3-异丙基苯 在 正丁基锂 作用下， 生成 2,3-dimethoxy-4-isopropylbenzyl alcohol
  参考文献：
  名称：

  The Total Snthesis of (±)-barbatusol

  摘要：

  An eight-step synthesis of the naturally occurring hypotensive diterpene barbatusol (3) featuring a Friedel-Crafts annulation is reported.

  DOI：

  10.1016/0040-4039(93)85098-h

文献信息

• A Rh(II)-catalyzed cycloaddition approach toward the synthesis of komaroviquinone
  作者：Albert Padwa、Majid J. Chughtai、Jutatip Boonsombat、Paitoon Rashatasakhon

  DOI：10.1016/j.tet.2008.01.129

  日期：2008.5

  Using a rhodium (II)-catalyzed cyclization/cycloaddition sequence as the key reaction step, the icetexane core of komaroviquinone was constructed by an intramolecular dipolar-cycloaddition of a carbonyl ylide dipole across a tethered pi-bond. The ylide was arrived at by cyclization of a rhodium carbenoid intermediate onto a proximal ester group. Efforts toward the preparation of the required precursor for elaboration to the natural product are discussed. (C) 2008 Elsevier Ltd. All rights reserved.
• Use of Conjugated Dienones in Cyclialkylations:  The Total Syntheses of (±)-Barbatusol, (±)-Pisiferin, (±)-Deoxofaveline, (±)-Xochitlolone, and (±)-Faveline
  作者：George Majetich、Rodgers Hicks、Yong Zhang、Xinrong Tian、Terry Lee Feltman、Jing Fang、Sam Duncan

  DOI：10.1021/jo9606968

  日期：1996.11.15

  Concise syntheses of five tricyclic diterpenoids are reported. The key reaction in each synthesis is a cyclialkylation of a functionalized arene with a Lewis acid-activated conjugated dienone to generate a 6,7,6-fused tricycle.
• The Total Snthesis of (±)-barbatusol
  作者：George Majetich、Yong Zhang、T. Lee Feltman、Sammy Duncan

  DOI：10.1016/0040-4039(93)85098-h

  日期：1993.1

  An eight-step synthesis of the naturally occurring hypotensive diterpene barbatusol (3) featuring a Friedel-Crafts annulation is reported.
• Ning, Chen; Wang, Xue-Chao; Pan, Xin-Fu, Synthetic Communications, 1999, vol. 29, # 12, p. 2115 - 2122
  作者：Ning, Chen、Wang, Xue-Chao、Pan, Xin-Fu

  DOI：——

  日期：——