6-benzoyl-1H-thieno[2,3-b][1,4]thiazin-2(3H)-one | 213402-42-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-benzoyl-1H-thieno[2,3-b][1,4]thiazin-2(3H)-one
• 英文别名: 6-benzoyl-1H-thieno[2,3-b][1,4]thiazin-2-one
• CAS: 213402-42-7
• 化学式: C₁₃H₉NO₂S₂
• 分子量: 275.352
• InChiKey: YMECRORMNDUECP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.02
• 重原子数：
  18.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  46.17
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  6-benzoyl-1H-thieno[2,3-b][1,4]thiazin-2(3H)-one 在 三乙基硅烷 作用下， 以 三氟乙酸 为溶剂， 反应 48.0h， 以72%的产率得到6-benzyl-2,3-dihydro-1H-thieno[2,3-b][1,4]thiazine-2-one
  参考文献：
  名称：

  Studies on the Chemistry of Thienoannelated O,N- and S,N-Containing Heterocycles. Part 19[1]: Thieno[2,3-b][1,4]thiazines with Calcium Antagonistic and Potassium Opening Activities

  摘要：

  In this study novel substituted 6-benzyl-thieno[2,3-b] [1,4]thiazines with an urea moiety were synthesized. Structural modifications of the amino side chain were carried out with the aim of finding tissue specific compounds. The effects on papillary muscles, right atria, aortic strips, and terminal ilea were investigated. Compounds 10c and 10d showed the most potent negative inotropic effect. The calcium antagonism of all derivatives occurred in a non-competitive manner, which may indicate that they also have potassium channel opening activities.

  DOI：

  10.1002/(sici)1521-4184(200002)333:2/3<58::aid-ardp58>3.0.co;2-l
• 作为产物：
  描述：

  (5-Chlor-4-nitro-2-thienyl)-phenylmethanon 在 铁粉 、 potassium carbonate 、 溶剂黄146 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 反应 18.5h， 生成 6-benzoyl-1H-thieno[2,3-b][1,4]thiazin-2(3H)-one
  参考文献：
  名称：

  Studies on the Chemistry of Thienoannelated O,N- and S,N-Containing Heterocycles. Part 19[1]: Thieno[2,3-b][1,4]thiazines with Calcium Antagonistic and Potassium Opening Activities

  摘要：

  In this study novel substituted 6-benzyl-thieno[2,3-b] [1,4]thiazines with an urea moiety were synthesized. Structural modifications of the amino side chain were carried out with the aim of finding tissue specific compounds. The effects on papillary muscles, right atria, aortic strips, and terminal ilea were investigated. Compounds 10c and 10d showed the most potent negative inotropic effect. The calcium antagonism of all derivatives occurred in a non-competitive manner, which may indicate that they also have potassium channel opening activities.

  DOI：

  10.1002/(sici)1521-4184(200002)333:2/3<58::aid-ardp58>3.0.co;2-l

文献信息

• Studies on the Chemistry of Thienoannelated O,N- and S,N-Containing Heterocycles. Part 19[1]: Thieno[2,3-b][1,4]thiazines with Calcium Antagonistic and Potassium Opening Activities
  作者：Thomas Erker、Maria E. Schreder、Christian Studenik

  DOI：10.1002/(sici)1521-4184(200002)333:2/3<58::aid-ardp58>3.0.co;2-l

  日期：2000.2

  In this study novel substituted 6-benzyl-thieno[2,3-b] [1,4]thiazines with an urea moiety were synthesized. Structural modifications of the amino side chain were carried out with the aim of finding tissue specific compounds. The effects on papillary muscles, right atria, aortic strips, and terminal ilea were investigated. Compounds 10c and 10d showed the most potent negative inotropic effect. The calcium antagonism of all derivatives occurred in a non-competitive manner, which may indicate that they also have potassium channel opening activities.