Methyl 2-[2-(4-methoxyphenyl)-2-oxoethyl]sulfanylacetate | 153783-90-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Methyl 2-[2-(4-methoxyphenyl)-2-oxoethyl]sulfanylacetate
• CAS: 153783-90-5
• 化学式: C₁₂H₁₄O₄S
• mdl: MFCD12645433
• 分子量: 254.307
• InChiKey: LRSMPZJJKFBZPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  77.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Methyl 2-[2-(4-methoxyphenyl)-2-oxoethyl]sulfanylacetate 在 乙酸铵 、 间氯过氧苯甲酸 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 12.0h， 生成 methyl 6-(4-methoxybenzoyl)-1-oxo-3,5-diphenyl-1,4-thiazinane-2-carboxylate
  参考文献：
  名称：

  Reddy, D. Bhaskar; Reddy, M. Muralidhar; Reddy, P. V. Ramana, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1993, vol. 32, # 10, p. 1018 - 1023

  摘要：

  DOI：
• 作为产物：
  描述：

  alpha-溴-4-甲氧基苯乙酮 在 sodium hydroxide 、 硫酸 作用下， 以 甲醇 为溶剂， 反应 7.0h， 生成 Methyl 2-[2-(4-methoxyphenyl)-2-oxoethyl]sulfanylacetate
  参考文献：
  名称：

  Reddy, D. Bhaskar; Reddy, M. Muralidhar; Reddy, P. V. Ramana, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1993, vol. 32, # 10, p. 1018 - 1023

  摘要：

  DOI：

文献信息

• Synthesis, antimicrobial, and cytotoxicity studies of novel sulfur-linked quinoline–coumarin bisheterocycles
  作者：Nidhin Paul、Shanmugam Muthusubramanian

  DOI：10.1007/s00044-013-0761-7

  日期：2014.3

  A series of sulfur attached quinolines and quinoline-coumarin bisheterocycles have been synthesized by the Friedlander reaction of methyl 2-[(2,4-diaryl-3-quinolyl)sulfanyl]acetate and subsequent reaction with salicylaldehyde. These compounds were screened for their in vitro antimicrobial activity against Gram-positive, Gram-negative bacteria, and fungal pathogen. Among the 19 compounds screened, preliminary results indicated that many of the compounds demonstrated moderate to good antimicrobial activities. The cytotoxic effects against mouse fibroblasts (NIH 3T3) in vitro were evaluated for the most active compound, which displayed no toxic effects.
• Bhaskar Reddy D., Muralidhar Reddy M., Ramana Reddy P. V., Indian J. Chem. B, 32 (1993) N 10, S 1018-1023
  作者：Bhaskar Reddy D., Muralidhar Reddy M., Ramana Reddy P. V.

  DOI：——

  日期：——
• Reddy, D. Bhaskar; Reddy, M. Muralidhar; Reddy, P. V. Ramana, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1993, vol. 32, # 10, p. 1018 - 1023
  作者：Reddy, D. Bhaskar、Reddy, M. Muralidhar、Reddy, P. V. Ramana

  DOI：——

  日期：——